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Sevoflurane requirement for laparoscopic tubal ligation: an electroencephalographic bispectral study

Published online by Cambridge University Press:  16 August 2006

A. Vakkuri ,
A. Yli-Hankala ,
K. Korttila  and
L. Lindgren
A. Vakkuri
Affiliation:
Anaesthesia Research Group, Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
A. Yli-Hankala
Affiliation:
Anaesthesia Research Group, Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
K. Korttila
Affiliation:
Anaesthesia Research Group, Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
L. Lindgren
Affiliation:
Fourth Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
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Abstract

It has been shown in healthy volunteers that a concentration of volatile anaesthetic lower than 1 minimum alveolar concentration provides unconsciousness. We tested the hypothesis that, using the electroencephalogram bispectral index, less than 1 minimum alveolar concentration of sevoflurane can produce unconsciousness in patients. Anaesthesia was induced and maintained with sevoflurane in N2O and O2 (33%) in 32 ASA I-II women undergoing laparoscopic tubal ligation. For the first patient, the sevoflurane concentration was adjusted to 1 minimum alveolar concentration with an end-tidal concentration of 0.7%. The electroencephalogram bispectral index values were used to determine the concentration to be used for the next patient. The ED50 (effective dose) measured using end tidal concentrations of sevoflurane for laparoscopic tubal ligation in a 40-year-old patient was 0.70% (CI 95%: 0.63–0.77) and ED95 0.83% (CI 95%: 0.75–0.90). None of the patients had any operation-associated recall. It is concluded that the sevoflurane concentration needed for laparoscopic tubal ligation is not lower than 1 minimum alveolar concentration.

Keywords

sevofluraneambulatory anaesthesiaelectroencephalogram bispectral index
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 16 , Issue 5 , May 1999 , pp. 279 - 283
Copyright
1999 European Society of Anaesthesiology

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