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Effects of thiopental on bispectral index and heart rate variability

Published online by Cambridge University Press:  01 March 2006

S. Tsuchiya ,
N. Kanaya ,
N. Hirata ,
S. Kurosawa ,
N. Kamada ,
M. Edanaga ,
M. Nakayama ,
K. Omote  and
A. Namiki
S. Tsuchiya
Affiliation:
Sapporo Medical University, School of Medicine, Department of Anesthesiology, Sapporo, Japan
N. Kanaya
Affiliation:
Sapporo Medical University, School of Medicine, Department of Anesthesiology, Sapporo, Japan
N. Hirata
Affiliation:
Sapporo Medical University, School of Medicine, Department of Anesthesiology, Sapporo, Japan
S. Kurosawa
Affiliation:
Sapporo Medical University, School of Medicine, Department of Anesthesiology, Sapporo, Japan
N. Kamada
Affiliation:
Sapporo Medical University, School of Medicine, Department of Anesthesiology, Sapporo, Japan
M. Edanaga
Affiliation:
Sapporo Medical University, School of Medicine, Department of Anesthesiology, Sapporo, Japan
M. Nakayama
Affiliation:
Sapporo Medical University, School of Medicine, Department of Anesthesiology, Sapporo, Japan
K. Omote
Affiliation:
Sapporo Medical University, School of Medicine, Department of Anesthesiology, Sapporo, Japan
A. Namiki
Affiliation:
Sapporo Medical University, School of Medicine, Department of Anesthesiology, Sapporo, Japan
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Extract

Summary

Background and objective: Thiopental has been reported to reduce sympathetic tone, however, it is not clear whether change in heart rate variability is associated with depth of anaesthesia. The purpose of the present study was to evaluate changes in heart rate variability at different depths of hypnosis during induction of anaesthesia with thiopental. Methods: We studied 17 ASA I patients scheduled for minor surgery. The depth of hypnosis was monitored by the BIS. Spectral analysis of heart rate variability using a maximum entropy method resulted in a characteristic power spectrum with two main regions, a high frequency and a low frequency. Haemodynamics, entropy, low frequency, high frequency and low frequency/high frequency were monitored in an awake state and after the induction of anaesthesia. Results: Heart rate increased in a BIS-dependent manner, whereas blood pressure showed no significant changes during the study period. High frequency, entropy and low frequency decreased with a reduction in the BIS value. Low frequency/high frequency showed no significant change during the study period. Conclusions: Induction of anaesthesia with thiopental increased heart rate and decreased high frequency, entropy and low frequency in a BIS-dependent manner, indicating that thiopental reduces cardiac parasympathetic tone depending on the depth of hypnosis.

Keywords

ANAESTHESIA GENERALANAESTHETICS INTRAVENOUS, thiopentalAUTONOMIC NERVOUS SYSTEM, heart rate variabilityELECTROENCEPHALOGRAPHY, bispectral index
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 23 , Issue 6 , June 2006 , pp. 454 - 459
Copyright
© 2006 European Society of Anaesthesiology

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