Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-23T22:21:16.817Z Has data issue: false hasContentIssue false
  • English
  • Français

Serological studies with human papova (wart) virus

Published online by Cambridge University Press:  15 May 2009

Marie M. Ogilvie
Marie M. Ogilvie
Affiliation:
Department of Bacteriology, University of Edinburgh
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Methods for demonstrating antibody to wart virus by complement fixation and passive haemagglutination tests are described and compared with the precipitin test of Almeida & Goffe (1965). The results reveal the much greater sensitivity of the passive haemagglutination method, particularly in the detection of the immunoglobulin M class of antibody. Both complement-fixing and precipitating antibody were detected in sera from patients whose warts had undergone a spontaneous resolution.

The presence of antibody to wart virus was demonstrated in sera from persons who had had warts up to 10 years previously, and in a few cases from those who thought they had never had warts.

The antigenic identity of virus from hand warts and plantar warts of the simple and mosaic types was revealed, and some evidence was obtained for similar identity of the virus from genital warts.

Type
Research Article
Information
Journal of Hygiene , Volume 68 , Issue 3 , September 1970 , pp. 479 - 490
Copyright
Copyright © Cambridge University Press 1970

References

REFERENCES

Almeida, J. D., Cinader, B. & Howatson, A. F. (1963). The structure of antigen-antibody complexes. A study by electron microscopy. Journal of Experimental Medicine 118, 327–39.CrossRefGoogle ScholarPubMed
Almeida, J. D. & Goffe, A. P. (1965). Antibody to wart virus in human sera demonstrated by electron microscopy and precipitin tests. Lancet ii, 1205–7.CrossRefGoogle Scholar
Almeida, J. D., Howatson, A. F. & Williams, M. G. (1962). Electron microscope study of human warts; sites of virus production and nature of the inclusion bodies. Journal of Investigative Dermatology 38, 337–45.CrossRefGoogle ScholarPubMed
Almeida, J. D., Oriel, J. D. & Stannard, L. M. (1969). Characterisation of the virus found in human genital warts. Microbios 1, 225–32.Google Scholar
Bradstreet, C. M. P. & Taylor, C. E. D. (1962). Technique of complement-fixation test applicable to the diagnosis of virus diseases. Monthly Bulletin of the Ministry of Health and the Public Health Laboratory Service 21, 96–104.Google Scholar
Carter, R. L. (1966). Antibody formation in infectious mononucleosis. British Journal of Haematology 12, 259–67.CrossRefGoogle ScholarPubMed
Conant, R. M. & Barron, A. L. (1967). Enhanced diffusion of enterovirus antigens in agar gel in the presence of protamine. Virology 33, 547–9.CrossRefGoogle ScholarPubMed
Cruickshank, R. (1965). Medical Microbiology, llth edn. p. 913. Edinburgh: Livingstone.Google Scholar
Dunn, A. E. G. & Ogilvie, M. M. (1968). Intranuclear virus particles in human genital wart tissue: observations on the ultrastructure of the epidermal layer. Journal of Ultrastructure Research 22, 282–95.CrossRefGoogle Scholar
Epstein, W. L. (1967). Cited by Rowson, K. E. K. & Mahy, B. W. J. (1967). Human papova (wart) virus. Bacteriological Reviews 31, 110–31.Google Scholar
Evans, C. A., Gorman, L. R., Ito, Y. & Weiser, R. S. (1962). Anti-tumour immunity in the Shope papilloma-carcinoma. Journal of the National Cancer Institute 29, 277–85.Google Scholar
Frithiof, L. & Wersall, J. (1967). Virus-like particles in papillomas of the human oral cavity. Archiv für die gesamte Virusforschung 21, 31–44.CrossRefGoogle ScholarPubMed
Goffe, A. P., Almeida, J. D. & Brown, F. (1966). Further information on the antibody response to wart virus. Lancet ii, 607–9.CrossRefGoogle Scholar
Herbert, W. J. (1967 a, b). In Handbook of Experimental Immunology, Ed. Weir, D. M.. (a) p. 702; (b) p. 1207. Oxford: Blackwell.Google Scholar
Hopkins, R. (1969). B.Sc. Thesis, Bacteriology Department, Edinburgh University.Google Scholar
Le Bouvier, G. L., Sussman, M. & Crawford, L. V. (1966). Antigenic diversity of mammalian papillomaviruses. Journal of General Microbiology 45, 497–501.CrossRefGoogle Scholar
Lee, K. P. & Olson, C. (1969). Precipitin response of cattle to bovine papilloma virus. Cancer Research 29, 1393–7.Google ScholarPubMed
Lefkowitz, S. S., Williams, J. A., Howard, B. E. & Sigel, M. M. (1966). Adenovirus antibody measured by the passive haemagglutination test. Journal of Bacteriology 91, 205–12.CrossRefGoogle Scholar
Maderna, C. (1935). La deviazione del complemento in infermi affetti da condilomi acuminati. Riforma medica 51, 93–4.Google Scholar
Melnick, J. L. (1962). Papova virus group. Science, New York 135, 1128–30.CrossRefGoogle ScholarPubMed
Osler, A. G., Mulligan, J. J. & Rodriguez, E. (1966). Weight estimates of rabbit antihuman serum albumin based on antigen-binding and precipitin analysis: specific haemagglutinating activities of 7S and 19S components. Journal of Immunology 96, 334–44.CrossRefGoogle Scholar
Pike, R. M. (1967). Antibody heterogeneity and serological reactions. Bacteriological Reviews 31, 157–74.CrossRefGoogle ScholarPubMed
Ruiter, M. & Van Mullem, P. (1966). Demonstration by electron microscopy of an intranuclear virus in epidermodysplasia verruciformis. Journal of Investigative Dermatology 47, 247–52.CrossRefGoogle Scholar
Schmidt, N. J. & Lennette, E. H. (1966). The complement-fixing antigen of rubella virus. Proceedings of the Society of Experimental Biology and Medicine 121, 243–50.CrossRefGoogle ScholarPubMed
Scott, L. V., Felton, F. G. & Barney, J. A. (1957). Haemagglutination with herpes simplex virus. Journal of Immunology 78, 211–13.CrossRefGoogle ScholarPubMed
Sever, J. L., Huebner, R. J., Castellano, G. A., Sarma, P. S., Fabiyi, A., Schiff, G. M. & Cusumano, C. L. (1965). Rubella complement-fixation test. Science, New York 148, 385–7.CrossRefGoogle ScholarPubMed
Smith, J. W., Pinkel, D. & Dabrowski, S. (1969). Detection of a small virus in a cultivated human Wilms' tumour. Cancer (New York) 24, 527–31.Google Scholar
Watson, D. H., Russell, W. C. & Wildy, P. (1963). Electron microscopic particle counts on herpes virus, using the phosphotungstate negative staining technique. Virology 19, 250–60.CrossRefGoogle ScholarPubMed