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146 Effect of Heroin Use on Changes of Brain Functions as Measured by fMRI, a Systematic Review

Published online by Cambridge University Press:  15 June 2018

Jungjin Kim ,
Ayman Fareed ,
Bethany Ketchen ,
Woo Jin Kwak ,
Danzhao Wang ,
Hilaire Shongo-Hiango  and
Karen Drexler
Jungjin Kim
Affiliation:
Resident Psychiatrist, Emory University School of Medicine, Atlanta, Georgia
Ayman Fareed
Affiliation:
Associate Professor, Emory University School of Medicine, Atlanta, Georgia and Atlanta VA Medical Center, Decatur, Georgia
Bethany Ketchen
Affiliation:
Staff Psychologist, Atlanta VA Medical Center, Decatur, Georgia
Woo Jin Kwak
Affiliation:
Staff Psychologist, Atlanta VA Medical Center, Decatur, Georgia
Danzhao Wang
Affiliation:
Staff Psychologist, Atlanta VA Medical Center, Decatur, Georgia
Hilaire Shongo-Hiango
Affiliation:
Staff Psychologist, Atlanta VA Medical Center, Decatur, Georgia
Karen Drexler
Affiliation:
Associate Professor, Emory University School of Medicine, Atlanta, Georgia and Deputy National Mental Health Program Director, Addictive Disorders, Office of Mental Health Services - Veterans Healthcare Administration
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Abstract

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Abstract

In this study the authors focus on reviewing imaging studies that used resting state functional magnetic resonance imaging for individuals with a history of heroin use. This review study compiled existing research addressing the effect of heroin use on decision making by reviewing available functional neuroimaging data. Systematic review ofthe literatures using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. Eligible articles were retrieved through a computer-based MEDLINE and PsycINFO search from 1960 to December 2015 using the major medical subject headings “heroin, fMRI” (all fields). Only English language was included. Thirty-seven articles were initially included in the review. Sixteen were excluded because they did not meet the inclusion criteria. The results of 21 articles that met all the inclusion criteria were presented. Based on the 21 studies included in the current review, there is evidence that heroin use may have a direct and damaging effect on certain brain functions and that these changes may be associated with impulsive and unhealthy decision making. From the review of these studies, the authors understand that a longer duration of heroinuse may be associated with more damaging effects on brain functions. The authors also understand that these brain changes could last long after abstinence, which may increase the risk of relapse to heroin use. More research is needed to create a biomarker map for patients with heroin use disorder that can be used to guide and assess response to treatment.

Funding Acknowledgements

No funding.

Type
Abstracts
Information
CNS Spectrums , Volume 23 , Issue 1 , February 2018 , pp. 91
Copyright
© Cambridge University Press 2018