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Sick sinus syndrome: a family study

Published online by Cambridge University Press:  11 September 2013

Natalia Rogińska*
Affiliation:
Klinika Kardiologii Instytutu, “Pomnik – Centrum Zdrowia Dziecka” (Cardiology Clinic, The Children's Memorial Health Institute), Head of Department: Wanda Kawalec, Poland
Katarzyna Bieganowska
Affiliation:
Klinika Kardiologii Instytutu, “Pomnik – Centrum Zdrowia Dziecka” (Cardiology Clinic, The Children's Memorial Health Institute), Head of Department: Wanda Kawalec, Poland
*
Correspondence to: Lek. med. N. Rogińska, Klinika Kardiologii Instytutu, “Pomnik –Centrum Zdrowia Dziecka”, al. Dzieci Polskich 20, 04-730 Warszawa, Poland. Tel: +22 815 73 77; mobile: 604086542; E-mail: [email protected]

Abstract

A case of related individuals affected by sick sinus syndrome is presented in this study. The clinical and electrocardiographic signs of sinus node dysfunction and the most common causes of this disease are presented. Subsequently, the article includes descriptions of sinus node disease in three related children as well as details of the disease in their relatives. A literature review of the genetics of familial sinus node dysfunction concludes the study.

Type
Images in Congenital Cardiac Disease
Copyright
Copyright © Cambridge University Press 2013 

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References

1. Kozłowski, D. Zaburzenia przewodzenia w elektrokardiografii. Wydawnictwo Akademia Medycyny, Warszawa, 2011: 9, 37–40, 44–52.Google Scholar
2. Szymaniak, E. Choroba węzła zatokowego. In: Kubicka K, Bieganowska K (red.). Zaburzenia rytmu serca u dzieci. Wydawnictwo Lekarskie. PZWL, Warszawa, 2001: 283–305.Google Scholar
3. Ector, H, Van der Hauwaert, LG. Sick sinus syndrome in childhood. Br Heart J 1980; 44: 684691.CrossRefGoogle ScholarPubMed
4. Developed in Collaboration with the European Heart Rhythm Association. Guidelines for cardiac pacing and cardiac resynchronization therapy: The Task Force for Cardiac Pacing and Cardiac Resynchronization Therapy of the European Society of Cardiology. Eur Heart J 2007; 28: 22562295.CrossRefGoogle Scholar
5. Schott, JJ, Alshinawi, C, Kyndt, F. Cardiac conduction defects associate with mutations in SCN5A. Nat Genet 1999; 23: 2021.CrossRefGoogle ScholarPubMed
6. Benson, DW, Wang, DW, Dyment, M. Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A). J Clin Invest 2003; 112: 10191028.CrossRefGoogle ScholarPubMed
7. Milansesi, R, Baruscotti, M, Gnecchi-Ruscone, T, DiFrancesco, D. Familial sinus bradycardia associated with mutation in cardiac pacemaker channel. N Engl J Med 2006; 354: 151157.CrossRefGoogle Scholar
8. Holm, H, Gudbjartsson, DF, Sulem, P. A rare variant in MYH6 is associated with high risk of sick sinus syndrome. Nat Genet 2011; 43: 316320.CrossRefGoogle ScholarPubMed
9. Nof, E, Glikson, M, Antzelevitch, C. Genetics and sinus node dysfunction. J Atr Fibrillation 2009; 1: 328336.Google ScholarPubMed