Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-28T10:29:44.516Z Has data issue: false hasContentIssue false

Safety of etomidate bolus administration in patients with septic shock

Published online by Cambridge University Press:  11 May 2015

Rob Green*
Affiliation:
Department of Emergency Medicine, Department of Anesthesia, Division of Critical Care, Queen Elizabeth II Health Sciences Centre; Dalhousie University, Halifax, NS
Sean K. Gorman
Affiliation:
Department of Pharmacy, Capital District Health Authority and College of Pharmacy, Dalhousie University, Halifax, NS
*
Department of Medicine: Division of Critical Care and Department of Emergency Medicine, Queen Elizabeth II Health Sciences Centre, Dalhousie University, 377 Bethune Building, 1276 South Park Street, Halifax, NS B3H 2Y9; [email protected]

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Knowledge to Practice • Des connaissances à la pratique
Copyright
Copyright © Canadian Association of Emergency Physicians 2011

References

REFERENCES

1.Zed, PJ, Abu-Laban, RB, Harrison, DW. Intubating conditions and hemodynamic effects of etomidate for rapid sequence intubation in the emergency department: an observational cohort study. Acad Emerg Med 2006;13:378–83, doi:10.1111/j.1553-2712.2006.tb00313.x.Google Scholar
2.Bergen, JM, Smith, DC. A review of etomidate for rapid sequence intubation in the emergency department. J Emerg Med 1997;15:221–30, doi:10.1016/S0736-4679(96)00350-2.Google Scholar
3.Reynolds, SF, Heffner, J. Airway management of the critically ill patient: rapid-sequence intubation. Chest 2005;127:1397–412, doi:10.1378/chest.127.4.1397.Google Scholar
4.Jackson, WL. Should we use etomidate as an induction agent for endotracheal intubation in patients with septic shock? Chest 2005;127:1031–8, doi:10.1378/chest.127.3.1031.CrossRefGoogle ScholarPubMed
5.Allolio, B, Dorr, H, Stuttmann, R, et al. Effect of a singlebolus of etomidate upon eight major corticosteroid hormones and plasma ACTH. Clin Endocrinol 1985;22:281–6, doi:10.1111/j.1365-2265.1985.tb03241.x.CrossRefGoogle Scholar
6.Marik, PE, Pastores, SM, Annane, D, et al. Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med 2008;36:1937–49, doi:10.1097/CCM.0b013e31817603ba.CrossRefGoogle ScholarPubMed
7.Annane, D, Sebille, V, Troche, G, et al. A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA 2000;283:1038–45.CrossRefGoogle ScholarPubMed
8.Annane, D, Sebille, V, Charpentier, C, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002;288:862–71, doi:10.1001/jama.288.7.862.CrossRefGoogle ScholarPubMed
9.Sprung, CL, Annane, D, Keh, D, et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008;358:111–24, doi:10.1056/NEJMoa071366.CrossRefGoogle ScholarPubMed
10.Delinger, RP, Levy, MM, Carlet, JM, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008;36:296327, doi:10.1097/01.CCM.0000298158.12101.41.Google Scholar
11.Green, RS, Djogovic, D, Gray, S, et al. Canadian Association of Emergency Physicians Sepsis Guidelines: the optimal management of severe sepsis in Canadian emergency departments. CJEM 2008;10:443–59.Google Scholar
12.Jabre, P, Combes, X, Lapostolle, F, et al. Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial. Lancet 2009;374: 293300, doi:10.1016/S0140-6736(09)60949-1.CrossRefGoogle ScholarPubMed
13.Cuthbertson, BH, Sprung, CL, Annane, D, et al. The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock. Intensive Care Med 2009;35:1868–76, doi:10.1007/s00134-009-1603-4.CrossRefGoogle ScholarPubMed
14.Oglesby, AJ. Should etomidate be the induction agent of choice for rapid sequence intubation in the emergency department? Emerg Med J 2004;21:655–9, doi:10.1136/emj.2003.009043.Google Scholar
15.Franklin, C, Samuel, J, Hu, TC. Life-threatening hypotension associated with emergency intubation and the initiation of mechanical ventilation. Am J Emerg Med 1994;12:425–8, doi:10.1016/0735-6757(94)90053-1.CrossRefGoogle ScholarPubMed
16.Sivilotti, ML, Ducharme, J. Randomized, double-blind study on sedatives and hemodynamics during rapid-sequence intubation in the emergency department: the SHRED study Ann Emerg Med 1998;31:313–24, doi:10.1016/S0196-0644(98)70341-5.Google Scholar
17.Mort, TC. Complications of emergency tracheal intubation: hemodynamic alterations—part I. J Intensive Care Med 2007;22:157–65, doi:10.1177/0885066607299525.CrossRefGoogle ScholarPubMed
18.Marchick, MR, Kline, JA, Jones, AE. The significance of nonsustained hypotension in emergency department patients with sepsis. Intensive Care Med 2009;35:1261–4, doi:10.1007/s00134-009-1448-x.CrossRefGoogle ScholarPubMed
19.Katz, MH. Multivariable analysis: a practical guide for clinicians. Cambridge (UK): Cambridge University Press; 1999.Google Scholar