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Anatomical structure alone cannot predict function

Published online by Cambridge University Press:  30 August 2019

Dieter Jaeger  and
Erik De Schutter
Dieter Jaeger
Affiliation:
Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125 [email protected]
Erik De Schutter
Affiliation:
Born-Bunge Foundation, University of Antwerp-UIA, B2610 Antwerp, [email protected]/
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Abstract

The central hypothesis of Braitenberg et al.'s target article – that tidal waves of parallel fiber excitation precisely activate Purkinje cell spiking – is hard to reconcile with recent neurophysiological and modeling data. The assumed pattern of mossy fiber input seems unrealistic, inhibition is likely to interfere with the proposed excitatory responses, and moreover, computer simulations show that the Purkinje cell is a poor coincidence detector.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 20 , Issue 2 , June 1997 , pp. 252 - 253
Copyright
1997 Cambridge University Press

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