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The effects of cobalt and iodine supplementation of the pregnant ewe diet on immunoglobulin G, vitamin E, T3 and T4 levels in the progeny

Published online by Cambridge University Press:  01 February 2008

T. M. Boland ,
L. Hayes ,
T. Sweeney ,
J. J. Callan ,
A. W. Baird ,
S. Keely  and
T. F. Crosby
T. M. Boland*
Affiliation:
School of Agriculture, Food Science and Veterinary Medicine, College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland
L. Hayes
Affiliation:
School of Agriculture, Food Science and Veterinary Medicine, College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland
T. Sweeney
Affiliation:
School of Agriculture, Food Science and Veterinary Medicine, College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland
J. J. Callan
Affiliation:
School of Agriculture, Food Science and Veterinary Medicine, College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland
A. W. Baird
Affiliation:
School of Agriculture, Food Science and Veterinary Medicine, College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland
S. Keely
Affiliation:
School of Agriculture, Food Science and Veterinary Medicine, College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland
T. F. Crosby
Affiliation:
School of Agriculture, Food Science and Veterinary Medicine, College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland
*
E-mail: [email protected]
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Abstract

Sixty twin-bearing ewes were allocated to one of four dietary treatments investigating the effects of supplementary iodine or cobalt during late pregnancy on lamb serum immunoglobulin G (IgG), triiodothyronine (T3), thyroxine (T4) and vitamin E concentrations, and lamb IgG absorption efficiency. Ewes were offered grass silage ad libitum supplemented with 800 g per ewe per day of a 190 g/kg crude protein (CP) concentrate from day 126 of gestation until parturition plus one of the following supplements (n = 15 per treatment); no supplement (C); 26.6 mg iodine per day for final 3 weeks pre partum (I-3); 26.6 mg iodine/day for final week pre partum (I-1); 20 mg cobalt/day for final 3 weeks pre partum (Co-3). Lambs were blood sampled at 24 and 72 h post partum for serum IgG and vitamin E concentrations. Ten lambs from C and I-3 were blood sampled at 1 h post partum for serum IgG, vitamin E, T3 and T4 concentrations. There were no differences in serum IgG, vitamin E or T4 values (P > 0.05) at 1 h post partum between lambs born to the C and I-3 ewes. T3 levels were lower in I-3 compared with C progeny (P < 0.05). Supplemental iodine reduced colostral IgG absorption efficiency (P < 0.001) and lamb serum IgG concentrations at 24 and 72 h post partum (P < 0.001). Serum vitamin E concentration in I-3 and I-1 lambs was lower than in Co-3 lambs at 24 h post partum, while at 72 h post partum I-3, I-1 and Co-3 lambs had significantly lower concentrations than C lambs (P < 0.001). Supplementing the ewe’s diet with 26.6 mg/day of iodine for the final week of pregnancy reduced lamb serum IgG concentration at 24 and 72 h post partum. The lower total and free T3 values in the progeny of I-3-treated ewes suggest interference in the synthesis and metabolism of thyroid hormones when ewes receive excessive dietary iodine for 3 weeks immediately pre partum. Based on these findings, the indications are that the toxicity level for iodine in the diet of the pregnant ewe should be lowered to 20 mg per ewe per day, equivalent to 40% of its current level. The finding that high-level cobalt supplementation during the final 3 weeks of pregnancy will have a negative effect on serum vitamin E concentration at 72 h post partum is a new and significant finding and previously has not been reported in the literature.

Keywords

cobaltimmunoglobulin Giodinethyroid hormonesvitamin E
Type
Full Paper
Information
animal , Volume 2 , Issue 2 , February 2008 , pp. 197 - 206
Copyright
Copyright © The Animal Consortium 2008

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References

Agricultural Research Council 1980. The nutrient requirements of ruminant livestock. Commonwealth Agricultural Bureaux, Farnham Royal, UK.Google Scholar
Beckett, GJ, Russell, A, Nicol, F, Sahu, P, Wolf, CR, Arthur, JR 1992. Effect of selenium deficiency on hepatic type I 5-iodothyronine deiodinase activity and hepatic thyroid hormone levels in the rat. The Biochemical Journal 282, 483–486.CrossRefGoogle ScholarPubMed
Bieri, JG, Tolliver, TJ, Catignani, GL 1979. Simultaneous determination of α-tocopherol and retinal in plasma or red blood cells by high-pressure liquid chromatography. The American Journal of Clinical Nutrition 32, 2143–2149.CrossRefGoogle ScholarPubMed
Boland, TM, Brophy, PO, Callan, JJ, Quinn, PJ, Nowakowski, P, Crosby, TF 2004. The effects of mineral-block components when offered to ewes in late pregnancy on colostrum yield and immunoglobulin G absorption in their lambs. Animal Science 79, 293–302.CrossRefGoogle Scholar
Boland, TM, Brophy, PO, Callan, J, Quinn, PJ, Nowakowski, P, Crosby, TF 2005a. The effects of mineral supplementation to ewes in late pregnancy on colostrum yield and immunoglobulin G absorption in their lambs. Livestock Production Science 97, 141–150.CrossRefGoogle Scholar
Boland, TM, Guinan, M, Brophy, PO, Callan, JJ, Quinn, PJ, Nowakowski, P, Crosby, TF 2005b. The effects of varying levels of mineral and iodine supplementation to ewes during late pregnancy on serum immunoglobulin G concentration in their progeny. Animal Science 80, 209–218.CrossRefGoogle Scholar
Boland, TM, Callan, JJ, Brophy, PO, Quinn, PJ, Crosby, TF 2006. Lamb serum vitamin E and immunoglobulin G concentrations at 24 h post partum in response to various maternal mineral and iodine supplementation regimens. Animal Science 82, 319–326.CrossRefGoogle Scholar
Brody, T 1999. Vitamins. In Nutritional biochemistry, 2nd edition. Academic Press, San Diego.Google Scholar
Buckley, DJ, Morrissey, PA, Gray, JI 1995. Influence of dietary vitamin E on the oxidative stability and quality of pig meat. Journal of Animal Science 73, 3122–3131.CrossRefGoogle ScholarPubMed
Cabello, G, Levieux, D 1982. Absorption and half-life of bovine, caprine and ovine IgG1 in the newborn lamb. Effect of experimental prematurity and endocrine factors. Annales de Recherches Vétérinaires 12, 421–429.Google ScholarPubMed
Cabello, G, Wrutniak, C 1986. Plasma free and total iodothyronine levels in the newborn lamb. Physiological considerations. Reproduction Nutrition Development 26, 1281–1288.CrossRefGoogle ScholarPubMed
Cabello, G, Wrutniak, C 1989. Influence of experimental acidosis on the concentrations of thyreostimulin (TSH) and iodothyroninese (total T4, free T4, T3) in the plasma of the newborn lamb. Reproduction Nutrition Development 29, 509–515.CrossRefGoogle Scholar
Cabello, G, Levieux, D, Girardeau, JP, Lefaivre, J 1983. Intestinal K99+ Escherichia coli adhesion and absorption of colostral IgG1 in the newborn lamb: effect of foetal infusion of thyroid hormones. Research in Veterinary Science 35, 242–244.CrossRefGoogle ScholarPubMed
Campbell, SG, Siegel, MJ, Knowlton, BJ 1977. Sheep immunoglobulins and their transmission to the neonatal lamb. New Zealand Veterinary Journal 25, 361–365.CrossRefGoogle Scholar
Choksi, NY, Jahnke, GD, Hilaire, CS, Shelby, M 2003. Role of thyroid hormones in human and laboratory animal reproductive health. Birth Defects Research (Part B) 68, 479–491.CrossRefGoogle ScholarPubMed
Crosby, TF, Boland, TM, Brophy, PO, Quinn, PJ, Callan, JJ, Joyce, D 2004. The effects of offering mineral blocks to ewes pre-mating and in late pregnancy on block intake, pregnant ewe performance and immunoglobulin status of the progeny. Animal Science 79, 493–504.CrossRefGoogle Scholar
Davicco, MJ, Lefaivre, J, Barlet, JP 1982. Plasma iodothyronine levels in lambs during the perinatal period: influence of thyrotrophin injection. Reproduction Nutrition Development 22, 557–567.CrossRefGoogle ScholarPubMed
Donald, GE, Langlands, JP, Bowles, JE, Smith, AJ 1994. Subclinical selenium insufficiency 5. Selenium status and the growth and wool production of sheep supplemented with thyroid hormones. Australian Journal of Experimental Agricultural 34, 13–18.CrossRefGoogle Scholar
Doney, JM, Peart, JN, Smith, WF 1979. A consideration of the techniques for estimation of milk yield by suckled sheep and a comparison of estimates obtained by two methods in relation to the effect of breed, level of production and stage of lactation. Journal of Agricultural Science, Cambridge 92, 123–132.CrossRefGoogle Scholar
Fahey, JL, McKelvey, EM 1965. Quantitative determination of serum immunoglobulins in antibody agar plates. Journal of Immunology 94, 84–90.CrossRefGoogle ScholarPubMed
Gilbert, RP, Gaskins, CT, Hillers, JK, Parker, CF, McGuire, TC 1988. Genetic and environmental factors affecting immunoglobulin G1 concentrations in ewe colostrum and lamb serum. Journal of Animal Science 66, 855–863.CrossRefGoogle ScholarPubMed
Guinan, M, Harrison, G, Boland, TM, Crosby, TF 2005. The effect of varying levels of mineral and iodine supplementation to ewes during late pregnancy on serum immunoglobulin G concentrations in their progeny. Animal Science 80, 193–200.CrossRefGoogle Scholar
Hunter, AG, Reneau, JK, Williams, JB 1977. Factors affecting IgG concentration in day old lambs. Journal of Animal Science 45, 1146–1151.CrossRefGoogle ScholarPubMed
Jeffries, BC 1961. Body condition scoring and its use in management. Tasmanian Journal of Agriculture 32, 19–21.Google Scholar
Kececi, T 2003. Effect of low birthweight on serum thyroid hormones, glucose, urea and blood pH in newborn lambs. Turkish Journal of Veterinary and Animal Sciences 27, 395–399.Google Scholar
Kelly, G 2000. Peripheral metabolism of thyroid hormone: a review. Alternative Medicine Review 5, 306–333.Google ScholarPubMed
Kohrle, J 1994. Thyroid hormone deiodination in target tissues – a regulatory role for the trace element selenium? Experimental and Clinical Endocrinology 102, 63–89.CrossRefGoogle ScholarPubMed
Larson, RE, Ward, ACS, Frederiksen, KR, Ardrey, WB, Frank, FW 1974. Capability of lambs to absorb immunoproteins from freeze-dried bovine colostrum. American Journal of Veterinary Research 35, 1061–1063.Google ScholarPubMed
McEwan, AD, Fisher, EW, Selman, IE, Penhale, WJ 1970. A turbidity test for the estimation of immune globulin levels in neonatal calf serum. Clinica Chimica Acta 27, 155–163.CrossRefGoogle ScholarPubMed
Mellor, DJ, Murray, L 1986. Making the most of colostrum at lambing. The Veterinary Record 118, 351–353.CrossRefGoogle ScholarPubMed
Nathanielsz, PW, Comline, RS, Silver, M, Thomas, AL 1973. Thyroid function in the foetal lamb during the last third of gestation. The Journal of Endocrinology 58, 535–546.CrossRefGoogle ScholarPubMed
National Research Council 1985. Nutrient requirements of sheep, 6th edition. National Academy of Sciences, Washington, DC.Google Scholar
Naziroglu, M, Cay, M, Tahan, V, Bal, R, Delibas, N 1998. Effects of selenium and vitamin E supplementation on concentrations of plasma thyroid hormones in lambs. Turkish Journal of Veterinary and Animal Sciences 22, 157–160.Google Scholar
Njeru, CA, McDowell, LR, Wilkinson, NS, Linda, SB, William, SN 1994. Pre and postpartum supplemental DL-α-tocopherol acetate effects on placental and mammary vitamin E transfer in sheep. Journal of Animal Science 72, 1636–1640.CrossRefGoogle ScholarPubMed
O’Doherty J 1994. Alternative methods of forage supplementation and their effects on ewe and lamb performance. PhD thesis, National University of Ireland.Google Scholar
O’Doherty, JV, Crosby, TF 1997a. The effect of diet in late pregnancy on colostrum production and immunoglobulin absorption in sheep. Animal Science 64, 87–96.CrossRefGoogle Scholar
O’Doherty, JV, Crosby, TF 1997b. The effect of diet in late pregnancy on progesterone concentration and colostrum yield in ewes. Theriogenology 46, 233–241.CrossRefGoogle Scholar
Parker, RJ, Nicol, AM 1990. The measurement of serum immunoglobulin concentration to estimate lamb colostrum intake. Proceedings of the New Zealand Society of Animal Production 50, 275–278.Google Scholar
Pattinson, SE, Davies, DAR, Winter, AC 1995. Changes in the secretion rate and production of colostrum by ewes over the first 24 h post partum. Animal Science 61, 63–68.CrossRefGoogle Scholar
Pehrson, B, Hakkarainen, J, Blomgren, L 1990. Vitamin E status in newborn lambs with special reference to the effect of DL-α-tocopherol acetate supplementation in late gestation. Acta Veterinaria Scandinavica 31, 359–367.CrossRefGoogle Scholar
Piosik, PA, Van Groenigen, M, Van Doorn, J, Baas, F, Vijlder, JJM 1997. Effect of maternal thyroid status on thyroid hormones and growth in congenitally hypothyroid goat fetuses during the second half of gestation. Endocrinology 138, 5–11.CrossRefGoogle ScholarPubMed
Puls, R 1994. Vitamin levels in animal health: diagnostic data and bibliographies, 1st edition. Sherpa International, Clearbrook, British Columbia, Canada.Google Scholar
Quigley, JD, Hammer, CJ, Russel, LE, Polo, J 2005. Passive immunity in newborn calves. In Calf and heifer rearing (ed. PC Garnsworthy), pp. 135–157. Nottingham University Press, UK.Google Scholar
Rock, MJ, Kincaid, RL, Carstens, GE 2001. Effects of prenatal source and level of dietary selenium on passive immunity and thermometabolism of newborn lambs. Small Ruminant Research 40, 129–138.CrossRefGoogle ScholarPubMed
Rogers PAM and Murphy WE 1999. Dry matter, major elements and trace elements in Irish grass, silage and hay. Teagasc Grange Webpages at 0forage.htm.Google Scholar
Rose, MT, Wolf, BT, Haresign, W 2007. Effect of the level of iodine in the diet of pregnant ewes on the concentration of immunoglobulin G in the plasma of neonatal lambs following the consumption of colostrum. The British Journal of Nutrition 97, 315–320.CrossRefGoogle ScholarPubMed
Sauvant, D, Perez, JM, Tran, G 2004. Tables of composition of nutritional values of feed materials, 2nd edition. Wageningen Academic Publishers.CrossRefGoogle Scholar
Sethi, V, Kapil, U 2004. Iodine deficiency and development of the brain. The Indian Journal of Pediatrics 74, 325–329.CrossRefGoogle Scholar
Slebodzinski, A 1965. Interaction between thyroid hormone and thyroxine binding proteins in the early neonatal period. The Journal of Endocrinology 32, 45–57.CrossRefGoogle ScholarPubMed
Slebodzinski, A 1995. Peroral administration of triiodothyronine (T3) affects absorption of immunolactoglobulins in calves. Reproduction, Nutrition, Development 35, 387–393.CrossRefGoogle ScholarPubMed
Smith, GH, Dawson, AMcL, Wells, PW, Burrells, C 1975. Immunoglobulin concentrations in ovine body fluids. Research in Veterinary Science 19, 189–194.CrossRefGoogle ScholarPubMed
Stanbury, JB 1996. In Present knowledge in nutrition, 7th edition (ed. EE Ziegler and LJ Filer), pp. 378. ILSI press, Washington DC.Google Scholar
Underwood, EJ 1981. The mineral nutrition of livestock, 2nd edition. CAB, Slough, UK.Google Scholar
Wichtel, JJ, Thompson, KG, Craigie, AL, Williamson, NB 1996. Effects of selenium and iodine supplementation on the growth rate, mohair production, and thyroid status of Angora goat kids. New Zealand Journal of Agricultural Research 39, 111–115.CrossRefGoogle Scholar
Wrutniak, C, Cabello, G 1987. Neonatal changes in plasma cortisol, free and total iodothyronine levels in control and hypotrophic lambs. Reproduction Nutrition Development 27, 945–953.CrossRefGoogle ScholarPubMed