Hostname: page-component-cd9895bd7-8ctnn Total loading time: 0 Render date: 2024-12-26T12:38:35.594Z Has data issue: false hasContentIssue false
  • English
  • Français

Metabolic Research in Monozygotic Twins with Diabetes Mellitus: Progress Report*

Published online by Cambridge University Press:  01 August 2014

T. Goecke ,
W. Grote  and
D. Grueneklee
T. Goecke*
Affiliation:
Department of Human Genetics and Anthropology and Diabetes Research Institute, University of Düsseldorf, German Federal Republic
W. Grote
Affiliation:
Department of Human Genetics and Anthropology and Diabetes Research Institute, University of Düsseldorf, German Federal Republic
D. Grueneklee
Affiliation:
Department of Human Genetics and Anthropology and Diabetes Research Institute, University of Düsseldorf, German Federal Republic
*
Institut für Humangenetik und Anthropologie, Ulenbergstrasse 127/129, Düsseldorf, German Federal Republic

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

An intravenous and oral glucose tolerance test and an intravenous tolbutamide test have been performed in 11 MZ twin pairs, discordant for diabetes mellitus. Blood sugar, immunoreactive insulin, and free fatty acids were determined. The research aimed at finding out whether prediabetic subjects may show any characteristic parameter which could be suggestive of the hereditary disposition. Three MZ twins of juvenile diabetics showed a normal blood glucose, immunoreactive insulin, and free fatty acids during the glucose and tolbutamide loads within a maximum of 10 years observation.

Type
7. Twin Studies in Medical and Clinical Genetics
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 25 , Issue 1 , January 1976 , pp. 281 - 288
Copyright
Copyright © The International Society for Twin Studies 1976

Footnotes

*

The investigations have been supported by the Deutsche Forschungs-Gemeinschaft.

References

REFERENCES

Cerasi, E., Luft, R. 1967. Insulin response to glucose infusion in diabetic and non-diabetic monozygotic twin pairs. Genetic control of insulin response? Acta Endocrinol., 55: 330–345.Google ScholarPubMed
Conard, V., Franckson, I.R.M., Bastenie, P.A., Kovacs, L. 1953. Etude critique du triangle d'hyperglycémie intraveineux chez l'homme normal et détermination d'un «coefficient d'assimilation glucidique». Arch. Int. Pharmacodyn. Ther., 13: 277–292.Google Scholar
Daweke, H., Grote, W., Gries, F.A., Liebermeister, H. 1970. Zur Genetik des Diabetes mellitus: Glukosetoleranz, Seruminsulin und freie Fettsäuren bei eineiigen Zwillingen. Dtsch. Med. Wochenschr., 95: 983–988.CrossRefGoogle Scholar
Dole, V.P. 1956. A relation between non-esterified acids in plasma and the metabolism of glucose. J. Clin. Invest., 35: 150–154.CrossRefGoogle ScholarPubMed
Dubowski, K.M. 1962. An orthotoluidine method for body fluid glucose determination. Clin. Chem., 8: 215–235.CrossRefGoogle Scholar
Gamble, D.R., Taylor, K.W. 1969. Seasonal incidence of diabetes mellitus. Br. Med. J., 3: 631–633.CrossRefGoogle ScholarPubMed
Gamble, D.R., Kinsley, M.L., Fitzgerald, M.G., Bolton, R., Taylor, K.W. 1969. Viral antibodies in diabetes mellitus. Br. Med. J., 3: 627–630.CrossRefGoogle ScholarPubMed
Grote, W., Daweke, H., Hessing, J. 1971. Weiterer Beitrag zur Genetik des Diabetes mellitus: Glukosetoleranz, Serum-Insulin und freie Fettsäuren bei eineiigen Zwillingen. Paper presented at: 12. Tagung d. Ges. f. Anthropologie und Humangenetik, Göttingen.Google Scholar
Hales, C.N., Rändle, P.J. 1960. Immunoassay of insulin with insulin-antibody precipitate. Biochem. J., 88: 137–146.CrossRefGoogle Scholar
Johannsen, K., Soeldner, J.S., Gleason, R.E., Gottlieb, M.S., Park, B.N., Kaufmann, R.L., Tan, M.H. 1974. Serum insulin and growth hormone response patterns in monozygotic twin siblings of juvenile diabetics. Diabetologia, 10: 357–400. Abstract.Google Scholar
Lange, H.J., Knick, B. 1965. Vermehrte Informationsnutzung beim Auswerten des intravenösen Tolbutamid-Tests. Klin. Wochenschr., 43: 215–220.CrossRefGoogle Scholar
Schilling, W. H., Oberdisse, K., Hüter, K.A., Blank, H. 1965. Vergleichende Untersuchung der oralen und intravenösen Glukosebelastung zur Erfassung einer verminderten Kohlenhydrattoleranz. Diabetologia, 1: 187–194.CrossRefGoogle Scholar
Siemens, H.W. 1924. Die Zwillingspathologie-ihre Bedeutung, ihre Methodik, ihre bisherigen Ergebnisse. Berlin: Springer.Google Scholar
Tattersall, R.B., Pyke, D.A. 1972. Diabetes in identical twins. Lancet, 2: 1120–1125.CrossRefGoogle ScholarPubMed
Toeller, M., Knussmann, R. 1973. Reproducibility of oral glucose tolerance tests with three different loads. Diabetologia, 9: 102–107.CrossRefGoogle ScholarPubMed
V. Verschuer, O. 1933. Die erbbiologische Zwillingsforschung. In Diehl, K., Verschuer, O. v. (eds.): Zwillingstuberkulose. Jena: Fischer.Google Scholar
Wide, L., Porath, J. 1966. Radioimmunosorbent assay for proteins with the use of Sephadex-coupled antibodies. Biochem. Biophys. Acta, 130: 257–260.CrossRefGoogle Scholar
Wide, L., Axén, R., Porath, J. 1967. Radioimmunosorbent assay for proteins. Chemical couplings of antibodies to insoluble dextran. Immunochemistry, 4: 381–386.CrossRefGoogle Scholar
Wide, L. 1969. Radioimmunoassays employing immunosorbents. Acta Endocrinol. [Suppl.] (Kbh.), 142: 207–221.Google ScholarPubMed