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Genetic Variance in Blood Pressure*

Published online by Cambridge University Press:  01 August 2014

N. O. Borhani ,
M. Feinleib ,
R.J. Garrison ,
J. C. Christian  and
R. H. Rosenman
N. O. Borhani*
Affiliation:
Department of Community Health, School of Medicine, University of California at Davis, California, USA
M. Feinleib
Affiliation:
National Heart and Lung Institute, NJH, Bethesda, Maryland, USA
R.J. Garrison
Affiliation:
National Heart and Lung Institute, NJH, Bethesda, Maryland, USA
J. C. Christian
Affiliation:
School of Medicine, University of Indiana, Indianapolis, Indiana, USA
R. H. Rosenman
Affiliation:
Mount Zion Hospital and Medical Center, San Francisco, California, USA
*
Department of Community Health, School of Medicine, University of California, Davis, California 95616, USA

Abstract

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The National Heart and Lung Institute Twin Study has examined 514 white adult male twin sets aged 42-56 with respect to blood pressure. The data were analyzed by a method of Christian et al. which eliminates possible biases in estimated genetic variances that could result from different total variances in MZ and DZ twins. Results of the test for the presence of genetic variance indicate that both systolic and diastolic blood pressure are to a considerable extent genetically controlled with an estimated heritability of 0.8 for systolic and 0.6 for diastolic pressure. Although these findings are at variance with some previous reports, it is thought that much of the discrepancy results from application of different analytic techniques, not in the data themselves. The application of these findings to our understanding of hypertension epidemiology and community hypertension control programs are discussed.

Type
5. Twin Studies in Human Genetics
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 25 , Issue 1 , January 1976 , pp. 137 - 144
Copyright
Copyright © The International Society for Twin Studies 1976

Footnotes

*

Supported in part by research contracts NIH-70-2246: NIH-70-2268: NIH-71-2307, National Heart and Lung Institute, NIH.

References

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