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The Catharanthus Roseus (Vinca Rosea) Alkaloids: A New Glass of Stathmokinetic Agents

Published online by Cambridge University Press:  01 August 2014

G. Cardinali ,
G. Cardinali  and
G. Centurelli
G. Cardinali
Affiliation:
Istituto di Genetica Medica dell'Università di Roma
G. Cardinali
Affiliation:
Istituto di Genetica Medica dell'Università di Roma
G. Centurelli
Affiliation:
Istituto di Genetica Medica dell'Università di Roma

Summary

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Vinblastine (VLB) and vincristine (VCR) are two alkaloids (extracted from the plant Catahranthus roseus) which possess a definite antitumor activity. The antitumor activity. The antimitotic action of these two alkaloids was studied both on normal bone marrow and leukemic cells. Comparative studies showed that they are, like colchicine, spindle poisons. They, however, differ from colchicine and its derivatives in some of their biological activities.

The problem of the relationship between antitumor and antimitotic activity of VLB and VCR is discussed.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 17 , Issue 1 , January 1968 , pp. 197 - 208
Copyright
Copyright © The International Society for Twin Studies 1968

References

Armstrong, J. G. et al. (1962). Hodgkin's disease, carcinoma of the breast and other tumors treated with Vinbiastine sulfate. Cancer Chemother. Rep., 18: 49–71, 1962.Google ScholarPubMed
Cardinali, G., Gardinali, G. (1967). Studies on the hematological effects of Vinblastine (VLB) and Vincristine (VCR). Proc. 10th Congr. Europ. Soc. Haemat., Strasbourg 1965; 11: 831–839.Google Scholar
Cardinali, G., Gardinali, G. et al. (1961). The stathmokinetic effect of Vincaleukoblastine on normal bone marrow and leukemic cells. Proc. Amer. Assoc. Cancer Res., 3: 215, and Cancer Res., 21: 1542-44.Google Scholar
Cardinali, G., Gardinali, G. et al. (1961). The colchicine method in the study of bone marrow cell proliferation. Blood, 18: 328–35.CrossRefGoogle Scholar
Cardinali, G., Gardinali, G. et al. (1961). Comparative effects of Colchicine and Vincalekuoblastine on bone marrow mitotic activity in Syrian hamster. Proc. Soc. Exp. Biol. Med., 107: 891–892.CrossRefGoogle Scholar
Cardinali, G., Gardinali, G. et al. (1963). Studies on the mechanism of action of Vincalekuoblastine Proc. IInd Int. Symp. Chemother., Naples 1961. III: 165–170.Google Scholar
Cardinali, G., Gardinali, G. et al. (1963). Studies on the antimitotic activity of Leurocristine (Vincristine). Blood, 21: 102–109.CrossRefGoogle Scholar
Cardinali, G., Gardinali, G. et al. (1963). Comparative studies on the stathmokinetic effect of Vincristine (VCR), Vinblastine (VLB) and Colchicine. Proc. Amer. Ass. Cancer Res., 4: 10.Google Scholar
Creasey, W. A., Markiw, M. E. (1964). Biochemical effects of the Vinca Alkaloids. II. A comparison of the effects of colchicine, Vinblastine and Vincristine on the synthesis of ribonucleic acids in Ehrlich ascites carcinoma cells. Biochem. Biophys. Acta, 87: 601–609.Google Scholar
Cutts, J. G. (1961). The effect of Vincaleukoblastine on dividing cells in vivo . Cancer Res., 21: 168–172.Google ScholarPubMed
Farnsworth, N. R. (1961). The pharmacognosy of the Periwinkles: Vinca and Catharanthus. Lloydia, 24: 105–138.Google Scholar
Johnson, I. S. et al. (1963). The Vinca alkaloids: a new class of oncolytic agents. Cancer Res., 23: 1390–1427.Google ScholarPubMed
Lawrence, G. H. M. (1959). Vinca and Catharanthus. Baileya, 7: 113–119.Google Scholar
Marmont, A. M., Damasio, E. E. The stathmokinetic effect of Vincristine sulfate in vivo on the cells of acute leukaemia. Proc. 10th Congr. Europ. Soc. Haemat., Strasbourg 1965 (in press).Google Scholar
Mehrotra, T. N., Cardinali, G. (1965). Effect of Colchicine and Catharanthus roseus (Vinca rosea) alkaloidsf on mitosis of Syrian hamster bone marrow cells. Ind. J. Pathol. Bact., 8: 98–102.Google Scholar
Neuss, N. et al. (1962). Vinca Alkaloids. XI- Structures of Leurocristine (LCR) and Vincaleukoblastine (VLB). J. Amer. Chem. Soc., 84: 1509–1510.CrossRefGoogle Scholar
Pichon, M. (1948). Classification des Apocynacées. IX Ranwolfiées, Alstoniées, Allamandées, Tabernémontanoidées. Mem. Mus. National Hist. Mat., 27: 153–251.Google Scholar
Vaitkevicious, V. E. et al. (1962). Cytological and clinical observations during Vincaleukoblastine therapy o disseminated cancer. Cancer, 15: 294–306.3.0.CO;2-E>CrossRefGoogle Scholar