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Olanzapine metabolism by CYP1A2/CYP2D6 and hyperglycaemia

Published online by Cambridge University Press:  24 June 2014

Kazuhiko Iwahashi*
Affiliation:
Health Administration Center, Azubu University, Sagamihara-City, Japan
*
Kazuhiko Iwahashi, MD, PhD, Health Administration Center, Azubu University, Sagamihara-City, 229-8501, Japan. E-mail: [email protected]

Abstract

The relationship between olanzapine metabolism by CYP1A2/CYP2D6 and hyperglycaemia was investigated. The higher blood olanzapine concentration may be effected by the abnormal metabolism, but not always caused by hyperglycaemia.

Type
Case Report
Copyright
Copyright © 2004 Blackwell Munksgaard

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References

Meatherall, R, Younes, J. Fatality from olanzapine induced hyperglycemia. J Forensic Sci 2002;47: 893896.CrossRefGoogle ScholarPubMed
Kozian, R. Olanzapine-induced diabetes mellitus. Psychiatr Prax 2002;29: 318320.DOI: 10.1055/s-2002-34039CrossRefGoogle ScholarPubMed
Caccia, S. New antipsychotic agents for schizophrenia: pharmacokinetics and metabolism update. Curr Opin Invest Drugs 2002;3: 10731080. Google ScholarPubMed
Nakajima, M, Yokoi, T, Mizutani, M, Kinoshita, M, Funayama, M, Kamataki, T. Genetic polymorphism in the 5′-flanking region of human CYP1A2 gene: effect on the CYP1A2 inducibility in humans. J Biochem (Tokyo) 1999;125: 803808.CrossRefGoogle ScholarPubMed
Chida, M, Yokoi, T, Fukui, T, Kinoshita, M, Yokota, J, Kamataki, T. Detection of three genetic polymorphisms in the 5′-flanking region and intron 1 of human CYP1A2 in the Japanese population. Jpn J Cancer Res 1999;90: 899902.CrossRefGoogle ScholarPubMed
Yokota, H, Tamura, S, Furuya, Het al. Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism. Pharmacogenetics 1993;3: 256263.CrossRefGoogle Scholar
Gaedigk, A, Blum, M, Gaedigk, R, Eichelbaum, M, Meyer, UA. Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism. Am J Hum Genet 1991;485: 943950. Google Scholar