Book contents
- Pediatric Pathology of Hematopoietic and Histiocytic Disorders
- Pediatric Pathology of Hematopoietic and Histiocytic Disorders
- Copyright page
- Epigraph
- Contents
- Contributors
- Section I General Hematology and Hematopathology
- Section II Non-Neoplastic Hematologic Disorders of Blood and Bone Marrow
- Section III Non-Neoplastic Disorders of Extramedullary Lymphoid Tissues
- Section IV Neoplastic Disorders of Bone Marrow
- Section V Mature Lymphoid Neoplasms
- Section VI Histiocytic Disorders and Neoplasms
- Chapter 24 Histiocytic Pathogenesis and Derivation
- Chapter 25 Identification of Macrophages and Dendritic Cells
- Chapter 26 Non-Neoplastic Accumulation of Histiocytes
- Chapter 27 Hemophagocytic Lymphohistiocytosis (HLH)
- Chapter 28 Histiocytic Inflammatory Neoplasms/Lesions
- Index
- References
Chapter 24 - Histiocytic Pathogenesis and Derivation
from Section VI - Histiocytic Disorders and Neoplasms
Published online by Cambridge University Press: 25 January 2024
Book contents
- Pediatric Pathology of Hematopoietic and Histiocytic Disorders
- Pediatric Pathology of Hematopoietic and Histiocytic Disorders
- Copyright page
- Epigraph
- Contents
- Contributors
- Section I General Hematology and Hematopathology
- Section II Non-Neoplastic Hematologic Disorders of Blood and Bone Marrow
- Section III Non-Neoplastic Disorders of Extramedullary Lymphoid Tissues
- Section IV Neoplastic Disorders of Bone Marrow
- Section V Mature Lymphoid Neoplasms
- Section VI Histiocytic Disorders and Neoplasms
- Chapter 24 Histiocytic Pathogenesis and Derivation
- Chapter 25 Identification of Macrophages and Dendritic Cells
- Chapter 26 Non-Neoplastic Accumulation of Histiocytes
- Chapter 27 Hemophagocytic Lymphohistiocytosis (HLH)
- Chapter 28 Histiocytic Inflammatory Neoplasms/Lesions
- Index
- References
Summary
The term histiocyte (tissue cell) has evolved and is now often used as a collective term for two related groups of immune regulatory cells, the monocyte-macrophages and the dendritic cell (DC)–accessory antigen-presenting cells (1). The histiocytic proliferations of childhood encompass benign and malignant accumulations of monocyte-macrophages and hematopoietic-derived DC with a clinical spectrum of indolent to aggressive lesions. Although distinguishing between their reactive and neoplastic states can be challenging at times, molecular-based testing can help refine the diagnosis of neoplastic accumulations (see also Chapter 28) (2, 3).
- Type
- Chapter
- Information
- Pediatric Pathology of Hematopoietic and Histiocytic Disorders , pp. 307 - 309Publisher: Cambridge University PressPrint publication year: 2024
References
Christie, LJ, Evans, AT, Bray, SE, Smith, ME, Kernohan, NM, Levison, DA, et al. Lesions resembling Langerhans cell histiocytosis in association with other lymphoproliferative disorders: a reactive or neoplastic phenomenon? Hum Pathol. 2006;37(1):32–9.Google Scholar
Shanmugam, V, Craig, JW, Hornick, JL, Morgan, EA, Pinkus, GS, Pozdnyakova, O. Cyclin D1 is expressed in neoplastic cells of Langerhans cell histiocytosis but not reactive Langerhans cell proliferations. Am J Surg Pathol. 2017;41(10):1390–6.Google Scholar
Guilliams, M, Ginhoux, F, Jakubzick, C, Naik, SH, Onai, N, Schraml, BU, et al. Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny. Nat Rev Immunol. 2014;14(8):571–8.Google Scholar
Ginhoux, F, Guilliams, M. Tissue-resident macrophage ontogeny and homeostasis. Immunity. 2016;44(3):439–49.Google Scholar
Reid, C, Fryer, P, Clifford, C, Kirk, A, Tikerpae, J, Knight, S. Identification of hematopoietic progenitors of macrophages and dendritic Langerhans cells (DL-CFU) in human bone marrow and peripheral blood. Blood. 1990;76(6):1139–49.Google Scholar
Allen, CE, Li, L, Peters, TL, Leung, HC, Yu, A, Man, TK, et al. Cell-specific gene expression in Langerhans cell histiocytosis lesions reveals a distinct profile compared with epidermal Langerhans cells. J Immunol. 2010;184(8):4557–67.Google Scholar
Durham, BH, Roos-Weil, D, Baillou, C, Cohen-Aubart, F, Yoshimi, A, Miyara, M, et al. Functional evidence for derivation of systemic histiocytic neoplasms from hematopoietic stem/progenitor cells. Blood. 2017;130(2):176–80.Google Scholar
Milne, P, Bigley, V, Bacon, CM, Neel, A, McGovern, N, Bomken, S, et al. Hematopoietic origin of Langerhans cell histiocytosis and Erdheim Chester disease in adults. Blood. 2017;130(2):167–75.Google Scholar
Schwentner, R, Jug, G, Kauer, MO, Schnöller, T, Waidhofer-Söllner, P, Holter, W, et al. JAG2 signaling induces differentiation of CD14(+) monocytes into Langerhans cell histiocytosis-like cells. J Leukoc Biol. 2019;105(1):101–11.Google Scholar
Lim, KPH, Milne, P, Poidinger, M, Duan, K, Lin, H, McGovern, N, et al. Circulating CD1c+ myeloid dendritic cells are potential precursors to LCH lesion CD1a+CD207+ cells. Blood Adv. 2020;4(1):87–99.Google Scholar
Hoeffel, G, Ginhoux, F. Fetal monocytes and the origins of tissue-resident macrophages. Cellular Immunology. 2018;330:5–15.Google Scholar
Bain, CC, Hawley, CA, Garner, H, Scott, CL, Schridde, A, Steers, NJ, et al. Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities. Nature Communications. 2016;7(1):ncomms11852.Google Scholar
Boyette, LB, Macedo, C, Hadi, K, Elinoff, BD, Walters, JT, Ramaswami, B, et al. Phenotype, function, and differentiation potential of human monocyte subsets. PLoS One. 2017;12(4):e0176460.Google Scholar
Stout, RD, Jiang, C, Matta, B, Tietzel, I, Watkins, SK, Suttles, J. Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences. J Immunol. 2005;175(1):342–9.Google Scholar
Collin, M, Bigley, V. Human dendritic cell subsets: an update. Immunology. 2018;154(1):3–20.Google Scholar
Collin, M, McGovern, N, Haniffa, M. Human dendritic cell subsets. Immunology. 2013;140(1):22–30.Google Scholar
Zaba, LC, Fuentes-Duculan, J, Steinman, RM, Krueger, JG, Lowes, MA. Normal human dermis contains distinct populations of CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages. J Clin Invest. 2007;117(9):2517–25.Google Scholar
van Nierop, K, de Groot, C. Human follicular dendritic cells: function, origin and development. Semin Immunol. 2002;14(4):251–7.Google Scholar
Aguzzi, A, Kranich, J, Krautler, NJ. Follicular dendritic cells: origin, phenotype, and function in health and disease. Trends Immunol. 2014;35(3):105–13.Google Scholar
Andriko, JW, Kaldjian, EP, Tsokos, M, Abbondanzo, SL, Jaffe, ES. Reticulum cell neoplasms of lymph nodes: a clinicopathologic study of 11 cases with recognition of a new subtype derived from fibroblastic reticular cells. Am J Surg Pathol. 1998;22(9):1048–58.Google Scholar
Fletcher, AL, Acton, SE, Knoblich, K. Lymph node fibroblastic reticular cells in health and disease. Nat Rev Immunol. 2015;15(6):350–61.Google Scholar
Emile, JF, Abla, O, Fraitag, S, Horne, A, Haroche, J, Donadieu, J, et al. Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood. 2016;127(22):2672–81.Google Scholar