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Chapter 12 - Solitary fibrous tumor, hemangiopericytoma, and related tumors

Published online by Cambridge University Press:  19 October 2016

By
Markku Miettinen
Edited by
Markku Miettinen
Markku Miettinen
Affiliation:
National Cancer Institute, Maryland
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Type
Chapter
Information
Modern Soft Tissue Pathology
Tumors and Non-Neoplastic Conditions
 , pp. 324 - 335
Publisher: Cambridge University Press
Print publication year: 2016

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References

Primary Sources

England, DM, Hochholzer, L, McCarthy, MJ. Localized benign and malignant fibrous tumors of the pleura: a clinicopathologic review of 223 cases. Am J Surg Pathol 1989;13:640–658.Google Scholar
Briselli, M, Mark, EJ, Dickersin, GR. Solitary fibrous tumors of the pleura: eight new cases and review of 360 cases in the literature. Cancer 1981;47:2678–2689.Google Scholar
Witkin, GB, Rosai, J. Solitary fibrous tumor of the mediastinum: a report of 14 cases. Am J Surg Pathol 1989;13:547–557.CrossRefGoogle ScholarPubMed
el-Naggar, AK, Ro, JY, Ayala, AG, Ward, R, Ordonez, NG. Localized fibrous tumor of the serosal cavities: immunohistochemical, electron-microscopic, and flow-cytometric DNA study. Am J Clin Pathol 1989;92:561–565.Google Scholar
Young, RH, Clement, PB, McCaughey, WT. Solitary fibrous tumors (“fibrous mesotheliomas”) of the peritoneum: a report on three cases and a review of literature. Arch Pathol Lab Med 1990;114:493–495.Google Scholar
Suster, S, Nascimento, AG, Miettinen, M, Sickel, JZ, Moran, CA. Solitary fibrous tumor of soft tissue: a clinicopathologic and immunohistochemical study of 12 cases. Am J Surg Pathol 1995;19:1257–1266.Google Scholar
Nascimento, AG. Solitary fibrous tumor: a ubiquitous neoplasm of mesenchymal differentiation. Adv Anat Pathol 1996;3:388–395.CrossRefGoogle Scholar
Strom, EH, Skjorten, F, Aarseth, LB, Haug, E. Solitary fibrous tumor of the pleura: an immunohistochemical, electron microscopic and tissue culture study of a tumor producing insulin-like growth factor I in a patient with hypoglycemia. Pathol Res Pract 1991;187:109–113.CrossRefGoogle Scholar
Fukasawa, Y, Takada, A, Tateno, M, et al. Solitary fibrous tumor of the pleura causing recurrent hypoglycemia by secretion of insulin-like growth factor II. Pathol Int 1998;48:47–52.CrossRefGoogle ScholarPubMed
Fukunaga, M, Naganuma, H, Nikaido, T, Harada, T, Ushigome, S. Extrapleural solitary fibrous tumor: a report of seven cases. Mod Pathol 1997;10:443–450.Google Scholar
Vallat-Decouvelaere, AV, Dry, SM, Fletcher, CD. Atypical and malignant solitary fibrous tumors in extrathoracic locations: evidence of their comparability to intra-thoracic tumors. Am J Surg Pathol 1998;22:1501–1511.Google Scholar
Brunnemann, RB, Ro, JY, Ordonez, NG, et al. Extrapleural solitary fibrous tumor: a clinicopathologic study of 24 cases. Mod Pathol 1999;12:1034–1042.Google Scholar
Hasegawa, T, Matsuno, Y, Shimoda, T, et al. Extrathoracic solitary fibrous tumors: their histological variability and potentially aggressive behavior. Hum Pathol 1999;30:1464–1473.Google Scholar
Morimitsu, Y, Nakajima, M, Hisaoka, M, Hashimoto, H. Extrapleural solitary fibrous tumor: clinicopathologic study of 17 cases and molecular analysis of the p53 pathway. APMIS 2000;108:617–625.Google Scholar
Moran, CA, Ishak, KG, Goodman, ZD. Solitary fibrous tumor of the liver: a clinicopathologic and immunohistochemical study of nine cases. Ann Diagn Pathol 1998;2:19–24.Google Scholar
Dorfman, DM, To, K, Dickersin, GR, Rosenberg, AE, Pilch, BZ. Solitary fibrous tumor of the orbit. Am J Surg Pathol 1994;18:281–287.Google Scholar
Westra, WH, Gerald, WL, Rosai, J. Solitary fibrous tumor: consistent CD34 immunoreactivity and occurrence in the orbit. Am J Surg Pathol 1994;18:992–998.CrossRefGoogle ScholarPubMed
Bernardini, FP, de Conciliis, C, Schneider, S, Kersten, RC, Kulwin, DR. Solitary fibrous tumor of the orbit: is it rare? Report of a case series and review of literature. Ophthalmology 2003;110:1442–1448.Google Scholar
Zukerberg, LR, Rosenberg, AE, Randolph, G, Pilch, BZ, Goodman, ML. Solitary fibrous tumor of the nasal cavity and paranasal sinuses. Am J Surg Pathol 1991;15:126–130.CrossRefGoogle ScholarPubMed
Witkin, GB, Rosai, J. Solitary fibrous tumor of the upper respiratory tract: a report of six cases. Am J Surg Pathol 1991;15:842–848.Google Scholar
Alawi, F, Stratton, D, Freedman, PD. Solitary fibrous tumor of oral soft tissues: a clinicopathologic and immunohistochemical study of 16 cases. Am J Surg Pathol 2001;25:900–910.CrossRefGoogle Scholar
Carneiro, SS, Scheithauer, BW, Nascimento, AG, Hirose, T, Davis, DH. Solitary fibrous tumor of the meninges: a lesion distinctive from fibrous meningioma: a clinicopathologic and immunohistochemical study. Am J Clin Pathol 1996;106:217–224.Google Scholar
Tihan, T, Viglione, M, Rosenblum, MK, Olivi, A, Burger, PC. Solitary fibrous tumor in the central nervous system: a clinicopathologic review of 18 cases and comparison to meningeal hemangiopericytomas. Arch Pathol Lab Med 2003;127:432–439.CrossRefGoogle ScholarPubMed
Bainbridge, TC, Singh, RR, Mentzel, T, Katenkamp, D. Solitary fibrous tumor of urinary bladder: report of two cases. Hum Pathol 1997;28:1204–1206.Google Scholar
Westra, WH, Grenko, RT, Epstein, J. Solitary fibrous tumor of the lower urogenital tract: a report of five cases involving the seminal vesicles, urinary bladder, and prostate. Hum Pathol 2000;31:63–68.Google Scholar
Wang, J, Arder, DA, Frankel, K, Weiss, LM. Large solitary fibrous tumor of the kidney: report of two cases and review of the literature. Am J Surg Pathol 2001;25:1194–1199.Google Scholar
Nielsen, GP, O’Connell, JX, Dickersin, GR, Rosenberg, AE. Solitary fibrous tumor of soft tissue: a report of 15 cases, including 5 malignant examples with light microscopic, immunohistochemical and ultrastructural data. Mod Pathol 1997;10:1028–1037.Google Scholar
Hanau, CA, Miettinen, M. Solitary fibrous tumor: histological and immunohistochemical spectrum of benign and malignant variants presenting at different sites. Hum Pathol 1995;26:440–449.CrossRefGoogle ScholarPubMed
Erdag, G, Qureshi, HS, Petterson, JW, Wick, MR. Solitary fibrous tumor of the skin: a clinicopathologic study of 10 cases and review of the literature. J Cutan Pathol 2007;34:844–850.Google Scholar
Enzinger, FM, Smith, BH. Hemangiopericytoma: an analysis of 106 cases. Hum Pathol 1976;7:61–82.Google Scholar
Demicco, EG, Park, MS, Araujo, DM, et al. Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model. Mod Pathol 2012;25:1298–1306.CrossRefGoogle ScholarPubMed
Thway, K, Hayes, A, Ieremia, E, Fisher, C. Heterologous osteosarcomatous and rhabdomyosarcomatous elements in dedifferentiated solitary fibrous tumor: further support for the concept of dedifferentiation in solitary fibrous tumor. Ann Diagn Pathol 2013;17:457–463.Google Scholar
van de Rijn, M, Lombard, CM, Rouse, RV. Expression of CD34 by solitary fibrous tumors of the pleura, mediastinum, and lung. Am J Surg Pathol 1994;18:814–820.CrossRefGoogle ScholarPubMed
Flint, A, Weiss, SW. CD-34 and keratin expression distinguishes solitary fibrous tumor (fibrous mesothelioma) of pleura from desmoplastic mesothelioma. Hum Pathol 1995;26:428–431.CrossRefGoogle ScholarPubMed
Chilosi, M, Facchetti, F, Dei Tos, AP, et al. bcl-2 expression in pleural and extrapleural solitary fibrous tumours. J Pathol 1997;181:362–367.Google Scholar
Schweizer, L, Koelsche, C, Sahm, F, et al. Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein. Acta Neuropathol 2013;125:651–658.Google Scholar
Doyle, LA, Vivero, M, Fletcher, CD, Mertens, F, Hornick, JL. Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics. Mod Pathol 2014;27:390–395.Google Scholar
Yoshida, A, Tsuta, K, Ohno, M, et al. STAT6 immunohistochemistry is helpful in the diagnosis of solitary fibrous tumors. Am J Surg Pathol 2014;38:552–559.CrossRefGoogle ScholarPubMed
Doyle, LA, Tao, D, Mariño-Enríquez, A. STAT6 is amplified in a subset of dedifferentiated liposarcoma. Mod Pathol 2014;27:1231–1237.Google Scholar
Ng, TL, Gown, AM, Barry, TS, et al. Nuclear beta-catenin in mesenchymal tumors. Mod Pathol 2005;18:68–74.Google Scholar
Robinson, DR, Wu, YM, Kalyana-Sundaram, S, et al. Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. Nat Genet 2013;45:180–185.Google Scholar
Mohajeri, A, Tayebwa, J, Collin, A, et al. Comprehensive genetic analysis identifies a pathognomonic NAB2/STAT6 fusion gene, nonrandom secondary genomic imbalances, and a characteristic gene expression profile in solitary fibrous tumor. Genes Chromosomes Cancer 2013;52:873–886.CrossRefGoogle Scholar
Barthelmeß, S, Geddert, H, Boltze, C, et al. Solitary fibrous tumors/hemangiopericytomas with different variants of the NAB2-STAT6 gene fusion are characterized by specific histomorphology and distinct clinicopathological features. Am J Pathol 2014;184:1209–1218.Google Scholar
Miettinen, MM, el-Rifai, W, Sarlomo-Rikala, M, Anderson, LC, Knuutila, S. Tumor size-related DNA copy number changes occur in solitary fibrous tumors but not in hemangiopericytomas. Mod Pathol 1997;10:1194–1200.Google Scholar
Ness, GO, Lybaeck, H, Ames, J, Rodahl, F. Chromosomal imbalances in a recurrent solitary fibrous tumor of the orbit. Cancer Genet Cytogenet 2005;162:38–44.CrossRefGoogle Scholar

Secondary Sources

Dei Tos, A, Seregard, S, Calonje, E, Chan, JKC, Fletcher, CDM. Giant cell angiofibroma: a distinctive orbital tumor in adults. Am J Surg Pathol 1995;19:1286–1293.Google ScholarPubMed
Guillou, L, Gebhard, S, Coindre, JM. Orbital and extraorbital giant cell angiofibroma: a giant cell-rich variant of solitary fibrous tumor? Clinicopathologic, immunohistochemical, and ultrastructural analysis of a series in favor of a unifying concept. Am J Surg Pathol 2000;24:971–979.Google Scholar
Thomas, R, Banerjee, SS, Eyden, BP, et al. A study of four cases of giant cell angiofibroma with documentation of some unusual features. Histopathology 2001;39:390–396.Google Scholar
Fletcher, CDM, Bridge, JA, Lee, JC. Extrapleural solitary fibrous tumour. In Pathology and Genetics: Tumours of Soft Tissue and Bone, Fletcher, CDM, Bridge, JA, Hogendoorn, PCW, Mertens, F (eds.) Lyon: WHO; 2013:80–82.Google Scholar
Tsuneyoshi, M, Daimaru, Y, Enjoji, M. Malignant hemangiopericytoma and other sarcomas with hemangiopericytoma-like pattern. Pathol Res Pract 1984;178:446–453.Google Scholar
Nappi, O, Ritter, JH, Pettinato, G, Wick, MR. Hemangiopericytoma: histopathological pattern or clinicopathologic entity? Semin Diagn Pathol 1995;12:221–232.Google Scholar
Stout, AP, Murray, MR. Hemangiopericytoma: a vascular tumor featuring Zimmerman’s pericytes. Ann Surg 1942;116:26–31.Google Scholar
Miettinen, M. Antibody specific to muscle actins in the differential diagnosis and classification of soft tissue tumors. Am J Pathol 1988;130:205–210.Google Scholar
Porter, PL, Bigler, SA, McNutt, M, Gown, AM. The immunophenotype of hemangiopericytomas and glomus tumors, with special reference to muscle protein expression: an immunohistochemical study and review of the literature. Mod Pathol 1991;4:46–52.Google Scholar
Mentzel, T, Calonje, E, Nascimento, AG, Fletcher, CD. Infantile hemangiopericytoma versus infantile myofibromatosis: study of a series suggesting a continuous spectrum of infantile myofibroblastic lesions. Am J Surg Pathol 1994;18:922–930.Google Scholar
Thompson, LD, Miettinen, M, Wenig, BM. Sinonasal-type hemangiopericytoma: a clinicopathologic and immunophenotypic analysis of 104 cases showing perivascular myoid differentiation. Am J Surg Pathol 2003;27:737–749.Google Scholar
Jaaskelainen, J, Servo, A, Haltia, M, Wahlstrom, T, Valtonen, S. Intracranial hemangiopericytoma: radiology, surgery, radiotherapy, and outcome in 21 patients. Surg Neurol 1985;23: 227–236.Google Scholar
Guthrie, BL, Ebersold, MJ, Scheithauer, BW, Shaw, EG. Meningeal hemangiopericytoma: histopathological features, treatment, and long-term follow-up of 44 cases. Neurosurgery 1989;25:514–522.Google Scholar
Mena, H, Ribas, JL, Pezeshkpour, GH, Cowan, DN, Parisi, JE. Hemangiopericytoma of the central nervous system: a review of 94 cases. Hum Pathol 1991;22:84–91.Google Scholar
Spitz, FR, Bouvet, M, Pisters, PW, Pollock, RE, Feig, BW. Hemangiopericytoma: a 20-year single-institution experience. Ann Surg Oncol 1998;5:350–355.Google Scholar
Espat, NJ, Lewis, JJ, Leung, D, et al. Conventional hemangiopericytoma: modern analysis of outcome. Cancer 2002;95:1746–1751.Google Scholar
Plukker, JT, Koops, HS, Molenaar, I, et al. Malignant hemangiopericytoma in three kindred members of one family. Cancer 1988;61:841–844.Google Scholar
Nielsen, GP, Dickersin, GR, Provenzal, JM, Rosenberg, AE. Lipomatous hemangiopericytoma: a histologic, ultrastructural and immunohistochemical study of a unique variant of hemangiopericytoma. Am J Surg Pathol 1995;19:748–756.Google Scholar
Folpe, AL, Devaney, K, Weiss, SW. Lipomatous hemangiopericytoma: a rare variant of hemangiopericytoma that may be confused with liposarcoma. Am J Surg Pathol 1999; 23:1201–1207.Google Scholar
Guillou, L, Gebhard, S, Coindre, JM. Lipomatous hemangiopericytoma: a fat-containing variant of solitary fibrous tumor? Clinicopathologic, immunohistochemical, and ultrastructural analysis of a series in favor of a unifying concept. Hum Pathol 2000;31:1108–1115.Google Scholar
Perry, A, Scheithauer, BW, Nascimento, AG. The immunophenotypic spectrum of meningeal hemangiopericytoma: a comparison with fibrous meningioma and solitary fibrous tumor of meninges. Am J Surg Pathol 1997;21:1354–1360.Google Scholar
Dardick, I, Hammar, SP, Scheithauer, BW. Ultrastructural spectrum of hemangiopericytoma: a comparative study of fetal, adult, and neoplastic pericytes. Ultrastruct Pathol 1989; 13:111–154.Google Scholar
Streekantaiah, C, Bridge, JA, Rao, UN, Neff, JR, Sandberg, AA. Clonal chromosomal abnormalities in hemangiopericytoma. Cancer Genet Cytogenet 1991;54:173–181.Google Scholar
Henn, W, Wullich, B, Thönnes, M, et al. Recurrent t(12;19)(q13;q13.3) in intracranial and extracranial hemangiopericytoma. Cancer Genet Cytogenet 1993;71:151–154.Google Scholar
Joseph, JT, Lisle, DK, Jacoby, LB, et al. NF2 gene analysis distinguishes hemangiopericytoma from meningiomas. Am J Pathol 1995;147:1450–1455.Google Scholar

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