Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-02T19:59:45.117Z Has data issue: false hasContentIssue false

17 - Psychoneuroimmunology

from Systemic Psychophysiology

Published online by Cambridge University Press:  27 January 2017

By
Michael R. Irwin  and
George M. Slavich
Edited by
John T. Cacioppo ,
Louis G. Tassinary  and
Gary G. Berntson
John T. Cacioppo
Affiliation:
University of Chicago
Louis G. Tassinary
Affiliation:
Texas A & M University
Gary G. Berntson
Affiliation:
Ohio State University
Get access

Summary

A summary is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Chapter
Information
Handbook of Psychophysiology , pp. 377 - 398
Publisher: Cambridge University Press
Print publication year: 2016

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Amit, I., Garber, M., Chevrier, N., Leite, A. P., Donner, Y., Eisenhaure, T., … & Regev, A. (2009). Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science, 326: 257–263.Google Scholar
Antoni, M. H. (2013). Psychosocial intervention effects on adaptation, disease course and biobehavioral processes in cancer. Brain, Behavior, and Immunity, 30: S88–S98.Google Scholar
Aschbacher, K., Epel, E., Wolkowitz, O. M., Prather, A. A., Puterman, E., & Dhabhar, F. S. (2012). Maintenance of a positive outlook during acute stress protects against pro-inflammatory reactivity and future depressive symptoms. Brain, Behavior, and Immunity, 26: 346–352.Google Scholar
Avitsur, R., Kinsey, S. G., Bidor, K., Bailey, M. T., Padgett, D. A., & Sheridan, J. F. (2007). Subordinate social status modulates the vulnerability to the immunological effects of social stress. Psychoneuroendocrinology, 32: 1097–1105.Google Scholar
Barton, G. M. (2008). A calculated response: control of inflammation by the innate immune system. Journal of Clinical Investigation, 118: 413–420.CrossRefGoogle Scholar
Benedetti, F., Lucca, A., Brambilla, F., Colombo, C., & Smeraldi, E. (2002). Interleukine-6 serum levels correlate with response to antidepressant sleep deprivation and sleep phase advance. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 26: 1167–1170.Google Scholar
Berkenbosch, F., van Oers, J., del Rey, A., Tilders, F., & Besedovsky, H. (1987). Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1. Science, 238: 524–526.Google Scholar
Besedovsky, H., del Rey, A., Sorkin, E., & Dinarello, C. A. (1986). Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science, 233: 52–54.Google Scholar
Bierhaus, A., Wolf, J., Andrassy, M., Rohleder, N., Humpert, P. M., Petrov, D., … & Nawroth, P. P. (2003). A mechanism converting psychosocial stress into mononuclear cell activation. Proceedings of the National Academy of Sciences of the USA, 100: 1920–1925.Google Scholar
Bower, J. E., Ganz, P. A., Aziz, N., Olmstead, R., Irwin, M. R., & Cole, S. W. (2007). Inflammatory responses to psychological stress in fatigued breast cancer survivors: relationship to glucocorticoids. Brain, Behavior and Immunity, 21: 251–258.CrossRefGoogle ScholarPubMed
Bower, J. E. & Irwin, M. R. (2016). Mind–body therapies and control of inflammatory biology: a descriptive review. Brain, Behavior, and Immunity, 51: 1–11.CrossRefGoogle ScholarPubMed
Breen, E. C., Rezai, A. I., Nakajima, K., Beall, G. N., Mitsuyasu, R. T., Hirano, T., … & Martinez-Maza, O. (1990). Infection with HIV is associated with elevated IL-6 levels and production. Journal of Immunology, 144: 480–484.CrossRefGoogle ScholarPubMed
Brown, R., Pang, G., Husband, A. J., & King, M. G. (1989). Suppression of immunity to influenza virus infection in the respiratory tract following sleep disturbance. Regional Immunology, 2: 321–325.Google ScholarPubMed
Bull, S. J., Huezo-Diaz, P., Binder, E. B., Cubells, J. F., Ranjith, G., Maddock, G., … & Pariante, C. M. (2009). Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment. Molecular Psychiatry, 14: 1095–1104.Google Scholar
Cappuccio, F. P., D’Elia, L., Strazzullo, P., & Miller, M. A. (2010). Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies. Sleep, 33: 585–592.Google Scholar
Carroll, J. E., Low, C. A., Prather, A. A., Cohen, S., Fury, J. M., Ross, D. C., & Marsland, A. L. (2011). Negative affective responses to a speech task predict changes in interleukin (IL)-6. Brain, Behavior, and Immunity, 25: 232–238.Google Scholar
Chen, E., Miller, G. E., Walker, H. A., Arevalo, J. M., Sung, C. Y., & Cole, S. W. (2009). Genome-wide transcriptional profiling linked to social class in asthma. Thorax, 64: 38–43.Google Scholar
Cohen, S., Doyle, W. J., Alper, C. M., Janicki-Deverts, D., & Turner, R. B. (2009). Sleep habits and susceptibility to the common cold. Archives of Internal Medicine, 169: 62–67.Google Scholar
Cohen, S., Janicki-Deverts, D., & Miller, G. E. (2007). Psychological stress and disease. Journal of the American Medical Association, 298: 1685–1687.Google Scholar
Cohen, S., Tyrrell, D. A. J., & Smith, A. P. (1991). Psychological stress and susceptibility to the common cold. New England Journal of Medicine, 325: 606–612.Google Scholar
Cole, S. W. (2009). Chronic inflammation and breast cancer recurrence. Journal of Clinical Oncology, 27: 3418–3419.Google Scholar
Cole, S. W., Arevalo, J. M., Manu, K., Telzer, E. H., Kiang, L., Bower, J. E., … & Fuligni, A. J. (2011a). Antagonistic pleiotropy at the human IL6 promoter confers genetic resilience to the pro-inflammatory effects of adverse social conditions in adolescence. Developmental Psychology, 47: 1173–1180.Google Scholar
Cole, S. W., Arevalo, J. M., Takahashi, R., Sloan, E. K., Lutgendorf, S. K., Sood, A. K., … & Seeman, T. E. (2010). Computational identification of gene–social environment interaction at the human IL6 locus. Proceedings of the National Academy of Sciences of the USA, 107: 5681–5686.Google Scholar
Cole, S. W., Hawkley, L. C., Arevalo, J. M., & Cacioppo, J. T. (2011b). Transcript origin analysis identifies antigen-presenting cells as primary targets of socially regulated gene expression in leukocytes. Proceedings of the National Academy of Sciences of the USA, 108: 3080–3085.Google Scholar
Cole, S. W., Hawkley, L. C., Arevalo, J. M., Sung, C. Y., Rose, R. M., & Cacioppo, J. T. (2007). Social regulation of gene expression in human leukocytes. Genome Biology, 8: 1–13.Google Scholar
Cole, S. W. & Kemeny, M. E. (1997). Psychobiology of HIV infection. Critical Reviews in Neurobiology, 11: 289–321.Google Scholar
Cole, S. W., Kemeny, M. E., & Taylor, S. E. (1997). Social identity and physical health: accelerated HIV progression in rejection-sensitive gay men. Journal of Personality and Social Psychology, 72: 320–335.CrossRefGoogle ScholarPubMed
Cole, S. W., Korin, Y. D., Fahey, J. L., & Zack, J. A. (1998). Norepinephrine accelerates HIV replication via protein kinase A-dependent effects on cytokine production. Journal of Immunology, 161: 610–616.Google Scholar
Collado-Hidalgo, A., Bower, J. E., Ganz, P. A., Irwin, M. R., & Cole, S. W. (2008). Cytokine gene polymorphisms and fatigue in breast cancer survivors: early findings. Brain, Behavior and Immunology, 22: 1197–1200.Google Scholar
Collado-Hidalgo, A., Sung, C., & Cole, S. (2006). Adrenergic inhibition of innate anti-viral response: PKA blockade of Type I interferon gene transcription mediates catecholamine support for HIV-1 replication. Brain, Behavior and Immunology, 20: 552–563.Google Scholar
Creswell, J. D., Irwin, M. R., Burklund, L. J., Lieberman, M. D., Arevalo, J. M., Ma, J., … & Cole, S. W. (2012). Mindfulness-based stress reduction training reduces loneliness and pro-inflammatory gene expression in older adults: a small randomized controlled trial. Brain, Behavior and Immunology, 26: 1095–1101.CrossRefGoogle ScholarPubMed
Curfs, J. H., Meis, J. F., & Hoogkamp-Korstanje, J. A. (1997). A primer on cytokines: sources, receptors, effects, and inducers. Clinical Microbiology Reviews, 10: 742–780.Google Scholar
Danese, A., Moffitt, T. E., Pariante, C. M., Ambler, A., Poulton, R., & Caspi, A. (2008). Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Archives of Generaal Psychiatry, 65: 409–415.Google Scholar
Dantzer, R., O’Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008). From inflammation to sickness and depression: when the immune system subjugates the brain. Nature Reviews Neuroscience, 9: 46–56.Google Scholar
Davis, M. C., Zautra, A. J., Younger, J., Motivala, S. J., Attrep, J., & Irwin, M. R. (2008). Chronic stress and regulation of cellular markers of inflammation in rheumatoid arthritis. Brain, Behavior, and Immunity, 22: 24–32.Google Scholar
DellaGioia, N. & Hannestad, J. (2010). A critical review of human endotoxin administration as an experimental paradigm of depression. Neuroscience & Biobehavioral Reviews, 34: 130–143.Google Scholar
Dew, M. A., Hoch, C. C., Buysse, D. J., Monk, T. H., Begley, A. E., Houck, P. R., … & Reynolds, C. F. III (2003). Healthy older adults’ sleep predicts all-cause mortality at 4 to 19 years of follow-up. Psychosomatic Medicine, 65: 63–73.Google Scholar
Dhabhar, F. S., Malarkey, W. B., Neri, E., & McEwen, B. S. (2012). Stress-induced redistribution of immune cells–from barracks to boulevards to battlefields: a tale of three hormones – Curt Richter Award winner. Psychoneuroendocrinology, 37: 1345–1368.Google Scholar
Dickerson, S. S., Gable, S. L., Irwin, M. R., Aziz, N., & Kemeny, M. E. (2009). Social-evaluative threat and proinflammatory cytokine regulation: an experimental laboratory investigation. Psychological Science, 20: 1237–1244.Google Scholar
Dickerson, S. S. & Kemeny, M. E. (2004). Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Psychological Bulletin, 130: 355–391.Google Scholar
Dickerson, S. S., Kemeny, M. E., Aziz, N., Kim, K. H., & Fahey, J. L. (2004). Immunological effects of induced shame and guilt. Psychosomtic Medicine, 66: 124–131.Google Scholar
Edwards, K. M., Burns, V. E., Reynolds, T., Carroll, D., Drayson, M., & Ring, C. (2006). Acute stress exposure prior to influenza vaccination enhances antibody response in women. Brain, Behavior, and Immunology, 20: 159–168.Google Scholar
Eisenberger, N. I., Berkman, E. T., Inagaki, T. K., Rameson, L. T., Mashal, N. M., & Irwin, M. R. (2010a). Inflammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward. Biological Psychiatry, 68: 748–754.CrossRefGoogle ScholarPubMed
Eisenberger, N. I., Inagaki, T. K., Mashal, N. M., & Irwin, M. R. (2010b). Inflammation and social experience: an inflammatory challenge induces feelings of social disconnection in addition to depressed mood. Brain, Behavior, and Immunity, 24: 558–563.Google Scholar
Eisenberger, N. I., Inagaki, T. K., Rameson, L. T., Mashal, N. M., & Irwin, M. R. (2009). An fMRI study of cytokine-induced depressed mood and social pain: the role of sex differences. NeuroImage, 47: 881–890.Google Scholar
Engler, H., Bailey, M. T., Engler, A., & Sheridan, J. F. (2004). Effects of repeated social stress on leukocyte distribution in bone marrow, peripheral blood and spleen. Journal of Neuroimmunology, 148: 106–115.Google Scholar
Frank, M. G., Hendricks, S. E., Johnson, D., & Burke, W. J. (1999). Antidepressants augment natural killer cell activity: in vivo and in vitro. Neuropsychobiology, 39: 18–24.CrossRefGoogle ScholarPubMed
Friedman, E. M. & Irwin, M. (1997). Modulation of immune cell function by the autonomic nervous system. Pharmacology Therapy, 74: 27–38.Google Scholar
Fuligni, A. J., Telzer, E. H., Bower, J., Cole, S. W., Kiang, L., & Irwin, M. R. (2009a). A preliminary study of daily interpersonal stress and C-reactive protein levels among adolescents from Latin American and European backgrounds. Psychosomatic Medicine, 71 (3): 329–33.Google Scholar
Fuligni, A. J., Telzer, E. H., Bower, J., Irwin, M. R., Kiang, L., & Cole, S. W. (2009b). Daily family assistance and inflammation among adolescents from Latin American and European backgrounds. Brain, Behavior, and Immunity, 23: 803–809.Google Scholar
Gimeno, D., Kivimäki, M., Brunner, E. J., Elovainio, M., De Vogli, R., Steptoe, A., … & Ferrie, J. E. (2009). Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study. Psychological Medicine, 39: 413–423.Google Scholar
Glaser, R. & Kiecolt-Glaser, J. K. (2005). Stress-induced immune dysfunction: implications for health. Nature Reviews Immunology, 5: 243–251.Google Scholar
Goebel, M. U., Mills, P. J., Irwin, M. R., & Ziegler, M. G. (2000). Interleukin-6 and tumor necrosis factor-alpha production after acute psychological stress, exercise, and infused isoproterenol: differential effects and pathways. Psychosomatic Medicine, 62: 591–598.CrossRefGoogle ScholarPubMed
Grebe, K. M., Takeda, K., Hickman, H. D., Bailey, A. L., Embry, A. C., Bennink, J. R., & Yewdell, J. W. (2009). Cutting edge: sympathetic nervous system increases proinflammatory cytokines and exacerbates influenza A virus pathogenesis. Journal of Immunology, 184: 540–544.Google Scholar
Gruys, E., Toussaint, M. J. M., Niewold, T. A., & Koopmans, S. J. (2005). Acute phase reaction and acute phase proteins. Journal of Zhejiang University Science B, 6: 1045–1056.Google Scholar
Haack, M., Sanchez, E., & Mullington, J. M. (2007). Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers. Sleep, 30: 1145–1152.Google Scholar
Harrison, N. A., Brydon, L., Walker, C., Gray, M. A., Steptoe, A., & Critchley, H. D. (2009). Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity. Biological Psychiatry, 66: 407–414.Google Scholar
Hart, B. L. (1988). Biological basis of the behavior of sick animals. Neuroscience & Biobehavioral Reviews, 12: 123–137.Google Scholar
Howren, M. B., Lamkin, D. M., & Suls, J. (2009). Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosomatic Medicine, 71: 171–186.Google Scholar
Hubbard, A. K. & Rothlein, R. (2000). Intercellular adhesion molecule-1 (ICAM-1) expression and cell signaling cascades. Free Radical Biology & Medicine, 28: 1379–1386.Google Scholar
Imeri, L. & Opp, M. R. (2009). How (and why) the immune system makes us sleep. Nature Reviews Neuroscience, 10: 199–210.Google Scholar
Irwin, M. R. (2015). Why sleep is important for health: a psychoneuroimmunology perspective. Annual Review of Psychology, 66: 2.1–2.30.CrossRefGoogle Scholar
Irwin, M. R., Carrillo, C., & Olmstead, R. (2010). Sleep loss activates cellular markers of inflammation: sex differences. Brain, Behavior, and Immunity, 24: 54–57.Google Scholar
Irwin, M. R. & Cole, S. W. (2011). Reciprocal regulation of the neural and innate immune systems. Nature Reviews Immunology, 11: 625–632.Google Scholar
Irwin, M. R., Costlow, C., Williams, H., Artin, K. H., Chan, C. Y., Stinson, D. L., … & Oxman, M. N. (1998). Cellular immunity to varicella-zoster virus in patients with major depression. Journal of Infectious Diseases, 178: S104–S108.Google Scholar
Irwin, M. R., Lacher, U., & Caldwell, C. (1992). Depression and reduced natural killer cytotoxicity: a longitudinal study of depressed patients and control subjects. Psychological Medicine, 22: 1045–1050.Google Scholar
Irwin, M. R., Levin, M. J., Carrillo, C., Olmstead, R., Lucko, A., Lang, N., … & Oxman, M. N. (2011). Major depressive disorder and immunity to varicella-zoster virus in the elderly. Brain, Behavior, and Immunity, 25: 759–766.Google Scholar
Irwin, M. R., Levin, M. J., Laudenslager, M. L., Olmstead, R., Lucko, A., Lang, N., … & Oxman, M. N. (2013). Varicella zoster virus-specific immune responses to a herpes zoster vaccine in elderly recipients with major depression and the impact of antidepressant medications. Clinical Infectious Diseases, 56: 1085–1093.Google Scholar
Irwin, M. R., McClintick, J., Costlow, C., Fortner, M., White, J., & Gillin, J. C. (1996). Partial night sleep deprivation reduces natural killer and cellular immune responses in humans. FASEB Journal, 10: 643–653.CrossRefGoogle ScholarPubMed
Irwin, M. R. & Miller, A. H. (2007). Depressive disorders and immunity: 20 years of progress and discovery. Brain, Behavior, and Immunity, 21: 374–383.CrossRefGoogle ScholarPubMed
Irwin, M. R., Olmstead, R., Breen, E. C., Witarama, T., Carrillo, C., Sadeghi, N., … & Cole, S. (2014b). Tai Chi, cellular inflammation, and transcriptome dynamics in breast cancer survivors with insomnia: a randomized controlled trial. Journal of the National Cancer Institute, 50: 295–301.Google Scholar
Irwin, M. R., Olmstead, R., Breen, E. C., Witarama, T., Carrillo, C., Sadeghi, N., … & Cole, S. (2015). Cognitive behavioral therapy and Tai Chi reverse cellular and genomic markers of inflammation in late life insomnia: a randomized controlled trial. Biological Psychiatry, 78: 721–729.Google Scholar
Irwin, M. R., Olmstead, R., Carrillo, C., Sadeghi, N., Breen, E. C., Witarama, T., … & Nicassio, P. (2014a). Cognitive behavioral therapy vs. Tai Chi for late life insomnia and inflammatory risk: a randomized controlled comparative efficacy trial. Sleep, 37: 1543–1552.Google Scholar
Irwin, M. R., Olmstead, R., Carrillo, C., Sadeghi, N., Fitzgerald, J. D., Ranganath, V. K., & Nicassio, P. M. (2012). Sleep loss exacerbates fatigue, depression, and pain in rheumatoid arthritis. Sleep, 35: 537–543.Google Scholar
Irwin, M. R., Olmstead, R., & Carroll, J. E. (2016). Sleep disturbance, sleep duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biological Psychiatry, 80: 40–52.CrossRefGoogle ScholarPubMed
Irwin, M. R., Olmstead, R., & Oxman, M. N. (2007). Augmenting immune responses to varicella zoster virus in older adults: a randomized, controlled trial of Tai Chi. Journal of the American Geriatrics Society, 55: 511–517.Google Scholar
Irwin, M. R., Olmstead, R., Valladares, E. M., Breen, E. C., & Ehlers, C. L. (2009). Tumor necrosis factor antagonism normalizes rapid eye movement sleep in alcohol dependence. Biological Psychiatry, 66: 191–195.Google Scholar
Irwin, M. R., Thompson, J., Miller, C., Gillin, J. C., & Ziegler, M. (1999). Effects of sleep and sleep deprivation on catecholamine and interleukin-2 levels in humans: clinical implications. Journal of Clinical Endocrinology and Metabolism, 84: 1979–1985.Google Scholar
Irwin, M. R., Wang, M., Campomayor, C. O., Collado-Hidalgo, A., & Cole, S. (2006). Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation. Archives of Internal Medicine, 166: 1756–1762.Google Scholar
Irwin, M. R., Wang, M., Ribeiro, D., Cho, H. J., Olmstead, R., Breen, E. C., … & Cole, S. (2008). Sleep loss activates cellular inflammatory signaling. Biological Psychiatry, 64: 538–540.Google Scholar
Jarcho, M. R., Slavich, G. M., Tylova-Stein, H., Wolkowitz, O. M., & Burke, H. M. (2013). Dysregulated diurnal cortisol pattern is associated with glucocorticoid resistance in women with major depressive disorder. Biological Psychology, 93: 150–158.Google Scholar
Karin, M. (2006). Nuclear factor-kappaB in cancer development and progression. Nature, 441: 431–436.Google Scholar
Kiecolt-Glaser, J. K., Bennett, J. M., Andridge, R., Peng, J., Shapiro, C. L., Malarkey, W. B., … & Glaser, R. (2014). Yoga’s impact on inflammation, mood, and fatigue in breast cancer survivors: a randomized controlled trial. Journal of Clinical Oncology, 32: 1040–1049.Google Scholar
Kiecolt-Glaser, J. K., Glaser, R., Gravenstein, S., Malarkey, W. B., & Sheridan, J. (1996). Chronic stress alters the immune response to influenza virus vaccine in older adults. Proceedings of the National Academy of Sciences of the USA, 93: 3043–3047.Google Scholar
Kiecolt-Glaser, J. K., Loving, T. J., Stowell, J. R., Malarkey, W. B., Lemeshow, S., Dickinson, S. L., & Glaser, R. (2005). Hostile marital interactions, proinflammatory cytokine production, and wound healing. Archives of General Psychiatry, 62: 1377–1384.Google Scholar
Kiecolt-Glaser, J. K., Preacher, K. J., MacCallum, R. C., Atkinson, C., Malarkey, W. B., & Glaser, R. (2003). Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proceedings of the National Academy of Sciences of the USA, 100: 9090–9095.Google Scholar
Kubera, M., Symbirtsev, A., Basta-Kaim, A., Borycz, J., Roman, A. Papp, M., & Claesson, M. (1996). Effect of chronic treatment with imipramine on interleukin-1 and interleukin-2 production by splenocytes obtained from rats subjected to a chronic mild stress model of depression. Polish Journal of Pharmacology, 48: 503–506.Google ScholarPubMed
Lange, T., Dimitrov, S., Bollinger, T., Diekelmann, S., & Born, J. (2011). Sleep after vaccination boosts immunological memory. Journal of Immunology, 187: 283–290.Google Scholar
Lange, T., Perras, B., Fehm, H. L., & Born, J. (2003). Sleep enhances the human antibody response to hepatitis A vaccination. Psychosomatic Medicine, 65: 831–835.Google Scholar
Lee, H. J., Takemoto, N., Kurata, H., Kamogawa, Y., Miyatake, S., O’Garra, A., & Arai, N. (2000). GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells. Journal of Experimental Medicine, 192: 105–115.Google Scholar
Lotrich, F. E., El-Gabalawi, H., Guenther, L. C., & Ware, C. F. (2011). The role of inflammation in the pathophysiology of depression: different treatments and their effects. Journal of Rheumatology, 88: 48–54.Google Scholar
Mangge, H., Kenzian, H., Gallistl, S., Neuwirth, G., Liebmann, P., Kaulfersch, W., … & Schauenstein, K. (1995). Serum cytokines in juvenile rheumatoid arthritis: correlation with conventional inflammation parameters and clinical subtypes. Arthritis and Rheumatism, 38: 211–220.Google Scholar
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008). Cancer-related inflammation. Nature, 454: 436–444.Google Scholar
Matthews, K. A., Schott, L. L., Bromberger, J. T., Cyranowski, J. M., Everson-Rose, S. A., & Sowers, M. (2010). Are there bi-directional associations between depressive symptoms and C-reactive protein in mid-life women? Brain, Behavior, and Immunity, 24: 96–101.Google Scholar
Matzinger, P. (2007). Friendly and dangerous signals: is the tissue in control? Nature Immunology, 8: 11–3.Google Scholar
Mays, J. W., Bailey, M. T., Hunzeker, J. T., Powell, N. D., Papenfuss, T., Karlsson, E. A., … & Sheridan, J. F. (2010). Influenza virus-specific immunological memory is enhanced by repeated social defeat. Journal of Immunology, 184: 2014–2025.Google Scholar
McEwen, B. S. (2007). Physiology and neurobiology of stress and adaptation: central role of the brain. Physiological Reviews, 87: 873–904.CrossRefGoogle ScholarPubMed
Medzhitov, R. (2008). Origin and physiological roles of inflammation. Nature, 454: 428–435.Google Scholar
Meier-Ewert, H. K., Ridker, P. M., Rifai, N., Regan, M. M., Price, M. J., Dinges, D. F., & Mullington, J. M. (2004). Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. Journal of the American College of Cardiology, 43: 678–683.Google Scholar
Miller, A. H., Ancoli-Israel, S., Bower, J. E., Capuron, L., & Irwin, M. R. (2008a). Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer. Journal of Clinical Oncology, 26: 971–982.Google Scholar
Miller, A. H., Maletic, V., & Raison, C. L. (2009a). Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biological Psychiatry, 65: 732–741.Google Scholar
Miller, G. E. & Chen, E. (2010). Harsh family climate in early life presages the emergence of a proinflammatory phenotype in adolescence. Psychological Science, 21: 848–856.Google Scholar
Miller, G. E., Chen, E., Fok, A. K., Walker, H., Lim, A., Nicholls, E. F., … & Kobor, M. S. (2009b). Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling. Proceedings of the National Academy of Sciences of the USA, 106: 14716–14721.Google Scholar
Miller, G. E., Chen, E., Sze, J., Marin, T., Arevalo, J. M., Doll, R., … & Cole, S. W. (2008b). A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-kappaB signaling. Biological Psychiatry, 64: 266–272.Google Scholar
Miller, G. E. & Cohen, S. (2001). Psychological interventions and the immune system: a meta-analytic review and critique. Health Psychology, 20: 47–63.Google Scholar
Miller, G. E., Cohen, S., Pressman, S. D., Barkin, A., Rabin, B., & Treanor, J. J. (2004). Psychological stress and antibody response to influenza vaccination: when is the critical period for stress, and how does it get inside the body? Psychosomatic Medicine, 66: 215–223.Google Scholar
Miller, G. E. & Cole, S. W. (1998). Social relationships and the progression of human immunodeficiency virus infection: a review of evidence and possible underlying mechanisms. Annals of Behavioral Medicine, 20: 181–189.Google Scholar
Miller, N. E. (1964). Some psychophysiological studies of the motivation and of the behavioral effects of illness. Bulletin of the British Psychological Society, 17: 1–20.Google Scholar
Moons, W. G., Eisenberger, N. I., & Taylor, S. E. (2010). Anger and fear responses to stress have different biological profiles. Brain, Behavior, and Immunity, 24: 215–219.Google Scholar
Morgan, N., Irwin, M. R., Chung, M., & Wang, C. (2014). The effects of mind–body therapies on the immune system: meta-analysis. PLoS One, 9: e100903.Google Scholar
Motivala, S. & Irwin, M.R. (2007). Sleep and immunity: cytokine pathways linking sleep and health outcomes. Current Directions in Psychological Science, 16: 21–25.Google Scholar
Mullington, J., Korth, C., Hermann, D. M., Orth, A., Galanos, C., Holsboer, F., & Pollmächer, T. (2000). Dose-dependent effects of endotoxin on human sleep. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 278: R947–R955.Google Scholar
Murphy, K. (2001). Janeway’s Immunobiology. New York: Garland.Google Scholar
Murphy, M. L. M., Slavich, G. M., Chen, E., & Miller, G. E. (2015). Targeted rejection predicts decreased anti-inflammatory gene expression and increased symptom severity in youth with asthma. Psychological Science, 26: 111–121.Google Scholar
Murphy, M. L. M., Slavich, G. M., Rohleder, N., & Miller, G. E. (2013). Targeted rejection triggers differential pro- and anti-inflammatory gene expression in adolescents as a function of social status. Clinical Psychological Science, 1: 30–40.CrossRefGoogle ScholarPubMed
Murray, D. R., Irwin, M., Rearden, C. A., Ziegler, M., Motulsky, H., & Maisel, M. S. (1992). Sympathetic and immune interactions during dynamic exercise: mediation via Beta2-adrenergic dependent mechanism. Circulation, 83: 203–213.Google Scholar
Nance, D. M. & Sanders, V. M. (2007). Autonomic innervation and regulation of the immune system (1987–2007). Brain, Behavior, and Immunity, 21: 736–745.Google Scholar
Nicklas, B. J., Hsu, F. C., Brinkley, T. J., Church, T., Goodpaster, B. H., Kritchevsky, S. B., & Pahor, M. (2008). Exercise training and plasma C-reactive protein and interleukin-6 in elderly people. Journal of the American Geriatrics Society, 56: 2045–2052.Google Scholar
O’Connor, M. F., Bower, J. E., Cho, H. J., Creswell, J. D., Dimitrov, S., Hamby, M. E., … & Irwin, M. R. (2009). To assess, to control, to exclude: effects of biobehavioral factors on circulating inflammatory markers. Brain, Behavior, and Immunity, 23: 887–897.Google Scholar
O’Connor, M. F., Motivala, S., Valladares, E. M., Olmstead, R. E., & Irwin, M. R. (2007). Sex differences in monocyte expression of IL-6: role of autonomic mechanisms. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 293: R145–R151.Google Scholar
O’Donovan, A., Slavich, G. M., Epel, E. S., & Neylen, T. C. (2013). Exaggerated neurobiological sensitivity to threat as a mechanism linking anxiety with increased risk for diseases of aging. Neuroscience & Biobehavioral Reviews, 37: 96–108.Google Scholar
Pace, T. W., Hu, F., & Miller, A. H. (2007). Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression. Brain, Behavior, and Immunity, 21: 9–19.Google Scholar
Pace, T. W., Mletzko, T. C., Alagbe, O., Musselman, D. L., Nemeroff, C. B., Miller, A. H., & Heim, C. M. (2006). Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress. American Journal of Psychiatry, 163: 1630–1633.Google Scholar
Panina-Bordignon, P., Mazzeo, D., Di Lucia, P., D’Ambrosio, D., Lang, R., Fabbri, L., … & Sinigaglia, F. (1997). β2-agonists prevent Th1 development by selective inhibition of interleukin 12. Journal of Clinical Investigation, 100: 1513–1519.Google Scholar
Patel, S. R., Malhotra, A., Gao, X., Hu, F. B., Neuman, M. I., & Fawzi, W. W. (2012). A prospective study of sleep duration and pneumonia risk in women. Sleep, 35: 97–101.Google Scholar
Patten, S. B., Williams, J. V. A., Lavorato, D. H., Modgill, G., Jetté, N., & Eliasziw, M. (2008). Major depression as a risk factor for chronic disease incidence: longitudinal analyses in a general population cohort. General Hospital Psychiatry, 30: 407–413.Google Scholar
Phillips, A. C., Carroll, D., Burns, V. E., & Drayson, M. (2009). Cardiovascular activity and the antibody response to vaccination. Journal of Psychosomatic Research, 67: 37–43.Google Scholar
Polsky, D., Doshi, J. A., Marcus, S., Oslin, D., Rothbard, A., Thomas, N., & Thompson, C. L. (2005). Long-term risk for depressive symptoms after a medical diagnosis. Archives of Internal Medicine, 165: 1260–1266.Google Scholar
Powell, N. D., Mays, J. W., Bailey, M. T., Hanke, M. L., & Sheridan, J. F. (2011). Immunogenic dendritic cells primed by social defeat enhance adaptive immunity to influenza A virus. Brain, Behavior, and Immunity, 25 (1): 46–52.Google Scholar
Prather, A. A., Hall, M., Fury, J. M., Ross, D. C., Muldoon, M. F., Cohen, S., & Marsland, A. L. (2012). Sleep and antibody response to hepatitis B vaccination. Sleep, 35: 1063–1069.Google Scholar
Raetz, C. R. & Whitfield, C. (2002). Lipopolysaccharide endotoxins. Annual Review of Biochemistry, 71: 635–700.Google Scholar
Raison, C. L. & Miller, A. H. (2003). Depression in cancer: new developments regarding diagnosis and treatment. Biological Psychiatry, 54: 283–294.Google Scholar
Raison, C. L., Rutherford, R. E., Woolwine, B. J., Shuo, C., Schettler, P., Drake, D. F., … & Miller, A. H. (2013). A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA Psychiatry, 70: 31–41.Google Scholar
Raison, C. L., Rye, D. B., Woolwine, B. J., Vogt, G. J., Bautista, B. M., Spivey, J. R., & Miller, A. H. (2010). Chronic interferon-alpha administration disrupts sleep continuity and depth in patients with hepatitis C: association with fatigue, motor slowing, and increased evening cortisol. Biological Psychiatry, 68: 942–949.Google Scholar
Renegar, K. B., Floyd, R. A., & Krueger, J. M. (1998). Effects of short-term sleep deprivation on murine immunity to influenza virus in young adult and senescent mice. Sleep, 21: 241–248.Google Scholar
Rhen, T. & Cidlowski, J. A. (2005). Antiinflammatory action of glucocorticoids: new mechanisms for old drugs. New England Journal of Medicine, 353: 1711–1723.CrossRefGoogle ScholarPubMed
Richlin, V. A., Arevalo, J. M., Zack, J. A., & Cole, S. W. (2004). Stress-induced enhancement of NF-kappaB DNA-binding in the peripheral blood leukocyte pool: effects of lymphocyte redistribution. Brain, Behavior, and Immunity, 18: 231–237.Google Scholar
Rooney, A. G., McNamara, S., Mackinnon, M., Fraser, M., Rampling, R., Carson, A., & Grant, R. (2011). Frequency, clinical associations, and longitudinal course of major depressive disorder in adults with cerebral glioma. Journal of Clinical Oncology, 29: 4307–4312.Google Scholar
Sapolsky, R., Rivier, C., Yamamoto, G., Plotsky, P., & Vale, W. (1987). Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science, 238: 522–524.Google Scholar
Schleifer, S. J., Keller, S. E., & Bartlett, J. A. (1999). Depression and immunity: clinical factors and therapeutic course. Psychiatry Research, 85: 63–69.Google Scholar
Schultze-Florey, C. R., Martínez-Maza, O., Magpantay, L., Breen, E. C., Irwin, M. R., Gündel, H., & O’Connor, M.-F. (2012). When grief makes you sick: bereavement induced systemic inflammation is a question of genotype. Brain, Behavior, and Immunity, 26: 1066–1071.Google Scholar
Slavich, G. M. (2015). Understanding inflammation, its regulation, and relevance for health: a top scientific and public priority. Brain, Behavior, and Immunity, 45: 13–14.Google Scholar
Slavich, G. M. & Cole, S. W. (2013). The emerging field of human social genomics. Clinical Psychological Science, 1: 331–348.Google Scholar
Slavich, G. M. & Irwin, M. R. (2014). From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychological Bulletin, 140: 774–815.Google Scholar
Slavich, G. M., Monroe, S. M., & Gotlib, I. H. (2011). Early parental loss and depression history: associations with recent life stress in major depressive disorder. Journal of Psychiatric Research, 45: 1146–1152.Google Scholar
Slavich, G. M., O’Donovan, A., Epel, E. S., & Kemeny, M. E. (2010). Black sheep get the blues: a psychobiological model of social rejection and depression. Neuroscience & Biobehavioral Reviews, 35: 39–45.Google Scholar
Slavich, G. M., Tartter, M. A., Brennan, P. A., & Hammen, C. (2014). Endogenous opioid system influences depressive reactions to socially painful targeted rejection life events. Psychoneuroendocrinology, 49: 141–149.CrossRefGoogle ScholarPubMed
Slavich, G. M., Thornton, T., Torres, L. D., Monroe, S. M., & Gotlib, I. H. (2009). Targeted rejection predicts hastened onset of major depression. Journal of Social and Clinical Psychology, 28: 223–243.Google Scholar
Sloan, E. K., Capitanio, J. P., Tarara, R. P., Mendoza, S. P., Mason, W. A., & Cole, S. W. (2007). Social stress enhances sympathetic innervation of primate lymph nodes: mechanisms and implications for viral pathogenesis. Journal of Neuroscience, 27: 8857–8865.Google Scholar
Smith, C. W., Marlin, S. D., Rothlein, R., Toman, C., & Anderson, D. C. (1989). Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro. Journal of Clinical Investigation, 83: 2008–2017.Google Scholar
Spiegel, K., Sheridan, J. F., & Van Cauter, E. (2002). Effect of sleep deprivation on response to immunization. Journal of the American Medical Association, 288: 1471–1472.Google Scholar
Thomas, K. S., Motivala, S., Olmstead, R., & Irwin, M. R. (2011). Sleep depth and fatigue: role of cellular inflammatory activation. Brain, Behavior, and Immunity, 25: 53–58.Google Scholar
Torres, M. A., Pace, T. W., Liu, T., Felger, J. C., Mister, D., Doho, G. H., … & Miller, A. H. (2013). Predictors of depression in breast cancer patients treated with radiation: role of prior chemotherapy and nuclear factor kappa B. Cancer, 119: 1951–1959.Google Scholar
Tyring, S., Gottlieb, A., Papp, K., Gordon, K., Leonardi, C., Wang, A., … & Krishnan, R. (2006). Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase III trial. Lancet, 367: 29–35.Google Scholar
Vedhara, K., Cox, N. K. M., Wilcock, G. K., Perks, P., Hunt, M., Anderson, S., … & Shanks, N. M. (1999). Chronic stress in elderly carers of dementia patients and antibody response to influenza vaccination. Lancet, 353: 627–631.Google Scholar
Wang, C., Banuru, R., Ramel, J., Kupelnick, B., Scott, T., & Schmid, C. H. (2010). Tai Chi on psychological well-being: systematic review and meta-analysis. BMC Complementary and Alternative Medicine, 10: 23.Google Scholar
Wang, C., Collet, J. P., & Lau, J. (2004). The effect of Tai Chi on health outcomes in patients with chronic conditions: a systematic review. Archives of Internal Medicine, 164: 493–501.Google Scholar
Watkins, L. R. & Maier, S. F. (1999). Implications of immune-to-brain communication for sickness and pain. Proceedings of the National Academy of Sciences of the USA, 96: 7710–7713.CrossRefGoogle ScholarPubMed
Wohleb, E. S., Hanke, M. L., Corona, A. W., Powell, N. D., Stiner, L. T. M., Bailey, M. T., … & Sheridan, J. F. (2011). Beta-adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat. Journal of Neuroscience, 31: 6277–6288.Google Scholar
Zautra, A. J., Davis, M. C., Reich, J. W., Nicassario, P., Tennen, H., Finan, P., … & Irwin, M. R. (2008). Comparison of cognitive behavioral and mindfulness meditation interventions on adaptation to rheumatoid arthritis for patients with and without history of recurrent depression. Journal of Consulting and Clinical Psychology, 76: 408–421.Google Scholar
Zautra, A. J., Yocum, D. C., Villanueva, I., Smith, B., Davis, M. C., Attrep, J., & Irwin, M. (2004). Immune activation and depression in women with rheumatoid arthritis. Journal of Rheumatology, 31: 457–463.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×