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1 - Endometrial Development and Gene Expression

Published online by Cambridge University Press:  16 February 2017

By
Alejandro Rincón ,
María Ruíz-Alonso ,
Patricia Díaz-Gimeno ,
Felipe Vilella  and
Carlos Simón
Edited by
Roy G. Farquharson  and
Mary D. Stephenson
Roy G. Farquharson
Affiliation:
Liverpool Women's Hospital
Mary D. Stephenson
Affiliation:
University of Illinois College of Medicine
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Type
Chapter
Information
Early Pregnancy , pp. 1 - 12
Publisher: Cambridge University Press
Print publication year: 2017

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References

Cha, J, Vilella, F, Dey, SK, Simon, C. Molecular interplay in successfull implantation in ten critical topics in reproductive medicine 2013; Washington, DC: Sanders, (Science/AAAS), pp. 44–8.Google Scholar
Niakan, KK, Han, J, Pedersen, RA, Simon, C, Pera, RA. Human preimplantation embryo development. Development 2012;139(5):829–41.CrossRefGoogle Scholar
Thouas, GA, Dominguez, F, Green, MP, Vilella, F, Simon, C, Gardner, DK. Soluble ligands and their receptors in human embryo development and implantation. Endocr Rev 2015;36(1):92–130.CrossRefGoogle ScholarPubMed
Cervelló, I, Gil-Sanchis, C, Mas, A, Delgado-Rosas, F, Martínez-Conejero, JA, Galán, A, et al. Human endometrial side population cells exhibit genotypic, phenotypic and functional features of somatic stem cells. PLoS ONE 2010;5(6):e10964.CrossRefGoogle ScholarPubMed
Hawkins, SM, Matzuk, MM. The menstrual cycle: basic biology. Ann N Y Acad Sci 2008;1135:10–18.CrossRefGoogle ScholarPubMed
Lessey, BA. Endometrial integrins and the establishment of uterine receptivity. Hum Reprod 1998;3:247–58.Google Scholar
Noyes, RW, Hertig, AT, Rock, J. Dating the endometrial biopsy. Am J Obstet Gynecol 1975;122(2):262–3.CrossRefGoogle ScholarPubMed
Garrido-Gómez, T, Dominguez, F, Quiñonero, A, Estella, C, Vilella, F, Pellicer, A, et al. Annexin A2 is critical for embryo adhesiveness to the human endometrium by RhoA activation through F-actin regulation. FASEB J 2012;26(9):3715–27.CrossRefGoogle Scholar
Wilcox, AJ, Baird, DD, Weinberg, CR. Time of implantation of the conceptus and loss of pregnancy. N Engl J Med 1999;340(23):1796–9.CrossRefGoogle ScholarPubMed
Finn, CA, Martin, L. The control of implantation. J Reprod Fertil 1974;39(1):195–206.CrossRefGoogle ScholarPubMed
Shoupe, D, Mishell, DR, Lacarra, M, Lobo, RA, Horenstein, J, d'Ablaing, G, et al. Correlation of endometrial maturation with four methods of estimating day of ovulation. Obstet Gynecol 1989;73(1):88–92.Google ScholarPubMed
Balasch, J, Fábregues, F, Creus, M, Vanrell, JA. The usefulness of endometrial biopsy for luteal phase evaluation in infertility. Hum Reprod 1992;7(7):973–7.CrossRefGoogle ScholarPubMed
Batista, MC, Cartledge, TP, Merino, MJ, Axiotis, C, Platia, MP, Merriam, GR, et al. Midluteal phase endometrial biopsy does not accurately predict luteal function. Fertil Steril 1993;59(2):294–300.CrossRefGoogle Scholar
Li, TC, Dockery, P, Rogers, AW, Cooke, ID. How precise is histologic dating of endometrium using the standard dating criteria? Fertil Steril 1989;51(5):759–63.CrossRefGoogle ScholarPubMed
Creus, M, Ordi, J, Fábregues, F, Casamitjana, R, Ferrer, B, Coll, E, et al. Alphavbeta3 integrin expression and pinopod formation in normal and out-of-phase endometria of fertile and infertile women. Hum Reprod 2002;17(9):2279–86.CrossRefGoogle ScholarPubMed
Murray, MJ, Meyer, WR, Zaino, RJ, Lessey, BA, Novotny, DB, Ireland, K, et al. A critical analysis of the accuracy, reproducibility, and clinical utility of histologic endometrial dating in fertile women. Fertil Steril 2004;81:1333–43.CrossRefGoogle ScholarPubMed
Coutifaris, C, Myers, ER, Guzick, DS, Diamond, MP, Carson, SA, Legro, RS, et al. Histological dating of timed endometrial biopsy tissue is not related to fertility status. Fertil Steril 2004;82:1264–72.CrossRefGoogle Scholar
Remohí, J, Ardiles, G, Garcia-Velasco, JA, Gaitán, P, Simón, C, Pellicer, A. Endometrial thickness and serum oestradiol concentrations as predictors of outcome in oocyte donation. Hum Reprod 1997;12(10):2271–6.CrossRefGoogle ScholarPubMed
Schena, M, Shalon, D, Davis, RW, Brown, PO. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 1995;270(5235):467–70.CrossRefGoogle ScholarPubMed
Schena, M, Shalon, D, Heller, R, Chai, A, Brown, PO, Davis, RW. Parallel human genome analysis: microarray-based expression monitoring of 1000 genes. Proc Natl Acad Sci USA 1996;93(20):10614–9.CrossRefGoogle ScholarPubMed
Brazma, A, Vilo, J. Gene expression data analysis. FEBS Lett 2000;480(1):17–24.CrossRefGoogle ScholarPubMed
Carson, DD, Lagow, E, Thathiah, A, Al-Shami, R, Farach-Carson, MC, Vernon, M, et al. Changes in gene expression during the early to midluteal (receptive phase) transition in human endometrium detected by high-density microarray screening. Mol Hum Reprod 2002;8(9):871–9.CrossRefGoogle ScholarPubMed
Kliman, HJ, Honig, S, Walls, D, Luna, M, McSweet, JC, Copperman, AB. Optimization of endometrial preparation results in a normal endometrial function test (EFT) and good reproductive outcome in donor ovum recipients. J Assist Reprod Genet 2006;23(7–8):299–303.CrossRefGoogle Scholar
Domínguez, F, Garrido-Gómez, T, López, JA, Camafeita, E, Quiñonero, A, Pellicer, A, et al. Proteomic analysis of the human receptive versus non-receptive endometrium using differential in-gel electrophoresis and MALDI-MS unveils stathmin 1 and annexin A2 as differentially regulated. Hum Reprod 2009;24(10):2607–17.CrossRefGoogle ScholarPubMed
Vilella, F, Ramirez, L, Berlanga, O, Martinez, S, Alama, P, Meseguer, M, et al. PGE2 and PGF2 concentrations in human endometrial fluid as biomarkers for embryonic implantation. J Clin Endocrinol Metab 2013;98(10):4123–32.CrossRefGoogle ScholarPubMed
Lessey, BA, Damjanovich, L, Coutifaris, C, Castelbaum, A, Albelda, SM, Buck, CA. Integrin adhesion molecules in the human endometrium. Correlation with the normal and abnormal menstrual cycle. J Clin Invest 1992;90(1):188–95.Google ScholarPubMed
Dubowy, RL, Feinberg, RF, Keefe, DL, Doncel, GF, Williams, SC, McSweet, JC, et al. Improved endometrial assessment using cyclin E and p27. Fertil Steril 2003;80(1):146–56.CrossRefGoogle ScholarPubMed
Hannan, NJ, Stephens, AN, Rainczuk, A, Hincks, C, Rombauts, LJF, Salamonsen, LA. 2D-DiGE analysis of the human endometrial secretome reveals differences between receptive and nonreceptive states in fertile and infertile women. J Proteome Res 2010;9(12):6256–64.CrossRefGoogle ScholarPubMed
Salamonsen, LA, Hannan, NJ, Dimitriadis, E. Cytokines and chemokines during human embryo implantation: roles in implantation and early placentation. Semin Reprod Med 2007;25(6):437–44.CrossRefGoogle ScholarPubMed
Díaz-Gimeno, P, Horcajadas, JA, Martínez-Conejero, JA, Esteban, FJ, Alamá, P, Pellicer, A, et al. A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature. Fertil Steril 2011;95(1):50–60, 60e1–15.CrossRefGoogle ScholarPubMed
Ruiz-Alonso, M, Blesa, D, Simón, C. The genomics of the human endometrium. BBA – Molecular Basis of Disease 2012;1822(12):1931–42.Google ScholarPubMed
Haouzi, D, Mahmoud, K, Fourar, M, Bendhaou, K, Dechaud, H, De Vos, J, et al. Identification of new biomarkers of human endometrial receptivity in the natural cycle. Human Reproduction 2009;24(1):198–205.CrossRefGoogle ScholarPubMed
Horcajadas, JA, Pellicer, A, Simón, C. Wide genomic analysis of human endometrial receptivity: new times, new opportunities. Hum Reprod Update 2007;13(1):77–86.CrossRefGoogle ScholarPubMed
Horcajadas, JA, Sharkey, AM, Catalano, RD, Sherwin, JRA, Domínguez, F, Burgos, LA, et al. Effect of an intrauterine device on the gene expression profile of the endometrium. J Clin Endocrinol Metab 2006;91(8):3199–207.CrossRefGoogle ScholarPubMed
Nevins, JR, Potti, A. Mining gene expression profiles: expression signatures as cancer phenotypes. Nat Rev Genet 2007;8(8):601–9.CrossRefGoogle ScholarPubMed
Horcajadas, JA, Riesewijk, A, Polman, J, van Os, R, Pellicer, A, Mosselman, S, et al. Effect of controlled ovarian hyperstimulation in IVF on endometrial gene expression profiles. Mol Hum Reprod 2005;11(3):195–205.CrossRefGoogle ScholarPubMed
Horcajadas, JA, Mínguez, P, Dopazo, J, Esteban, FJ, Dominguez, F, Giudice, LC, et al. Controlled ovarian stimulation induces a functional genomic delay of the endometrium with potential clinical implications. J Clin Endocrinol Metab 2008;93(11):4500–10.CrossRefGoogle ScholarPubMed
Martínez-Conejero, JA, Simón, C, Pellicer, A, Horcajadas, JA. Is ovarian stimulation detrimental to the endometrium? Reprod Biomed Online 2007;15(1):45–50.CrossRefGoogle ScholarPubMed
Mirkin, S, Nikas, G, Hsiu, J-G, Díaz, J, Oehninger, S. Gene expression profiles and structural/functional features of the peri-implantation endometrium in natural and gonadotropin-stimulated cycles. J Clin Endocrinol Metab 2004;89(11):5742–52.CrossRefGoogle ScholarPubMed
Simón, C, Oberye, J, Bellver, J, Vidal, C, Bosch, E, Horcajadas, JA, et al. Similar endometrial development in oocyte donors treated with either high-or standard-dose GnRH antagonist compared to treatment with a GnRH agonist or in natural cycles. Hum Reprod 2005;20(12):3318–27.CrossRefGoogle ScholarPubMed
Liu, J, Wang, L, Harvey-White, J, Huang, BX, Kim, H-Y, Luquet, S, et al. Multiple pathways involved in the biosynthesis of anandamide. Neuropharmacology 2008;54(1):1–7.CrossRefGoogle ScholarPubMed
Tapia, A, Gangi, LM, Zegers-Hochschild, F, Balmaceda, J, Pommer, R, Trejo, L, et al. Differences in the endometrial transcript profile during the receptive period between women who were refractory to implantation and those who achieved pregnancy. Hum Reprod 2008;23(2):340–51.Google ScholarPubMed
Koler, M, Achache, H, Tsafrir, A, Smith, Y, Revel, A, Reich, R. Disrupted gene pattern in patients with repeated in vitro fertilization (IVF) failure. Hum Reprod 2009;24(10):2541–8.CrossRefGoogle ScholarPubMed
Altmäe, S, Martínez-Conejero, JA, Salumets, A, Simón, C, Horcajadas, JA, Stavreus-Evers, A. Endometrial gene expression analysis at the time of embryo implantation in women with unexplained infertility. Mol Hum Reprod 2010;16(3):178–87.CrossRefGoogle ScholarPubMed
Evans, GE, Martínez-Conejero, JA, Phillipson, GTM, Simón, C, McNoe Les, A, Sykes, PH, et al. Gene and protein expression signature of endometrial glandular and stromal compartments during the window of implantation. Fertil Steril 2012;97(6):1365–73.e1–2.CrossRefGoogle ScholarPubMed
Gaide Chevronnay, HP, Galant, C, Lemoine, P, Courtoy, PJ, Marbaix, E, Henriet, P. Spatiotemporal coupling of focal extracellular matrix degradation and reconstruction in the menstrual human endometrium. Endocrinology 2009;150(11):5094–105.CrossRefGoogle ScholarPubMed
Díaz-Gimeno, P, Ruiz-Alonso, M, Blesa, D, Simón, C. Transcriptomics of the human endometrium. Int J Dev Biol 2014;58(2–4):127–37.CrossRefGoogle ScholarPubMed
Kao, LC, Tulac, S, Lobo, S, Imani, B, Yang, JP, Germeyer, A, et al. Global gene profiling in human endometrium during the window of implantation. Endocrinology 2002;143(6):2119–38.CrossRefGoogle ScholarPubMed
Simmen, FA, Simmen, RCM. Orchestrating the menstrual cycle: discerning the music from the noise. Endocrinology 2006;147(3):1094–6.CrossRefGoogle ScholarPubMed
Díaz-Gimeno, P, Ruiz-Alonso, M, Blesa, D, Bosch, N, Martínez-Conejero, JA, Alamá, P, et al. The accuracy and reproducibility of the endometrial receptivity array is superior to histology as a diagnostic method for endometrial receptivity. Fertil Steril 2013;99(2):508–17.CrossRefGoogle ScholarPubMed
Van 't Veer, LJ, Dai, H, van de Vijver, MJ, He, YD, Hart, AA, Mao, M, et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002;415:530–6.CrossRefGoogle ScholarPubMed
Ruiz-Alonso, M, Galindo, N, Pellicer, A, Simón, C. What a difference two days make: “personalized” embryo transfer (pET) paradigm: a case report and pilot study. Hum Reprod 2014;29(6):1244–7.CrossRefGoogle ScholarPubMed
Ruiz-Alonso, M, Blesa, D, Díaz-Gimeno, P, Gómez, E, Fernández-Sánchez, M, Carranza, F, et al. The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure. Fertil Steril 2013;100(3):818–24.CrossRefGoogle ScholarPubMed
DeSouza, L, Diehl, G, Yang, ECC, Guo, J, Rodrigues, MJ, Romaschin, AD, et al. Proteomic analysis of the proliferative and secretory phases of the human endometrium: protein identification and differential protein expression. Proteomics 2005;5(1):270–81.CrossRefGoogle ScholarPubMed
Parmar, T, Gadkar-Sable, S, Savardekar, L, Katkam, R, Dharma, S, Meherji, P, et al. Protein profiling of human endometrial tissues in the midsecretory and proliferative phases of the menstrual cycle. Fertil Steril 2009;92(3):1091–103.CrossRefGoogle ScholarPubMed
Li, J, Tan, Z, Li, M, Xia, T, Liu, P, Yu, W. Proteomic analysis of endometrium in fertile women during the prereceptive and receptive phases after luteinizing hormone surge. Fertil Steril 2011;95(3):1161–3.CrossRefGoogle ScholarPubMed
Rai, P, Kota, V, Sundaram, CS, Deendayal, M, Shivaji, S. Proteome of human endometrium: identification of differentially expressed proteins in proliferative and secretory phase endometrium. Proteomics Clin Appl 2010;4(1):48–59.CrossRefGoogle ScholarPubMed
Garrido-Gómez, T, Quiñonero, A, Antúnez, O, Díaz-Gimeno, P, Bellver, J, Simon, C, et al. Deciphering the proteomic signature of human endometrial receptivity. Hum Reprod 2014;29(9):1957–67.CrossRefGoogle ScholarPubMed
Daly, DC, Maslar, IA, Riddick, DH. Prolactin production during in vitro decidualization of proliferative endometrium. Am J Obstet Gynecol 1983;145(6):672–8.CrossRefGoogle ScholarPubMed
Giudice, LC, Dsupin, BA, Irwin, JC. Steroid and peptide regulation of insulin-like growth factor-binding proteins secreted by human endometrial stromal cells is dependent on stromal differentiation. J Clin Endocrinol Metab 1992;75(5):1235–41.Google ScholarPubMed
Lockwood, CJ, Nemerson, Y, Guller, S, Krikun, G, Alvarez, M, Hausknecht, V, et al. Progestational regulation of human endometrial stromal cell tissue factor expression during decidualization. J Clin Endocrinol Metab 1993;76(1):231–6.Google ScholarPubMed
Irwin, JC, Kirk, D, King, RJ, Quigley, MM, Gwatkin, RB. Hormonal regulation of human endometrial stromal cells in culture: an in vitro model for decidualization. Fertil Steril 1989;52(5):761–8.CrossRefGoogle Scholar
Garrido-Gomez, T, Dominguez, F, Lopez, JA, Camafeita, E, Quiñonero, A, Martinez-Conejero, JA, et al. Modeling human endometrial decidualization from the interaction between proteome and secretome. J Clin Endocrinol Metab 2011;96(3):706–16.CrossRefGoogle ScholarPubMed
Cheong, Y, Boomsma, C, Heijnen, C, Macklon, NS. Uterine secretomics: a window on the maternal-embryo interface. Fertil Steril 2013;99(4):1093–9.CrossRefGoogle ScholarPubMed
Van der Gaast, MH, Beier-Hellwig, K, Fauser, BCJM, Beier, HM, Macklon, NS. Endometrial secretion aspiration prior to embryo transfer does not reduce implantation rates. Reprod Biomed Online 2003;7(1):105–9.CrossRefGoogle Scholar
Casado-Vela, J, Rodriguez-Suarez, E, Iloro, I, Ametzazurra, A, Alkorta, N, García-Velasco, JA, et al. Comprehensive proteomic analysis of human endometrial fluid aspirate. J Proteome Res 2009;8(10):4622–32.CrossRefGoogle ScholarPubMed
Quehenberger, O, Armando, AM, Brown, AH, Milne, SB, Myers, DS, Merrill, AH, et al. Lipidomics reveals a remarkable diversity of lipids in human plasma. J Lipid Res 2010;51(11):3299–305.CrossRefGoogle ScholarPubMed
Wenk, MR. The emerging field of lipidomics. Nat Rev Drug Discov 2005;4(7):594–610.CrossRefGoogle ScholarPubMed
Ye, X, Hama, K, Contos, JJ, Anliker, B, Inoue, A, Skinner, MK, et al. LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing. Nature 2005;435(7038):104–8.CrossRefGoogle ScholarPubMed
Miravet-Valenciano, JA, Rincon-Bertolin, A, Vilella, F, Simón, C. Understanding and improving endometrial receptivity. Curr Opin Obstet Gynecol 2015;27(3):187–92.CrossRefGoogle ScholarPubMed
Yamagata, Y, Asada, H, Tamura, I, Lee, L, Maekawa, R, Taniguchi, K, et al. DNA methyltransferase expression in the human endometrium: down-regulation by progesterone and estrogen. Hum Reprod 2009;24(5):1126–32.CrossRefGoogle ScholarPubMed
Rahnama, F, Thompson, B, Steiner, M, Shafiei, F, Lobie, PE, Mitchell, MD. Epigenetic regulation of E-cadherin controls endometrial receptivity. Endocrinology 2009;150(3):1466–72.CrossRefGoogle ScholarPubMed
Sakai, N, Maruyama, T, Sakurai, R, Masuda, H, Yamamoto, Y, Shimizu, A, et al. Involvement of histone acetylation in ovarian steroid-induced decidualization of human endometrial stromal cells. J Biol Chem 2003;278(19):16675–82.CrossRefGoogle ScholarPubMed
Reis-Filho, JS. Next-generation sequencing. Breast Cancer Res 2009; 11(Suppl 3): S12.CrossRefGoogle ScholarPubMed
Mane, SP, Evans, C, Cooper, KL, Crasta, OR, Folkerts, O, Hutchison, SK, et al. Transcriptome sequencing of the Microarray Quality Control (MAQC) RNA reference samples using next-generation sequencing. BMC Genomics 2009;10:264.CrossRefGoogle ScholarPubMed

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