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5 - Binding Profile, Metabolism, Kinetics, Drug Interactions and Use of Plasma Levels

Published online by Cambridge University Press:  19 October 2021

Jonathan M. Meyer  and
Stephen M. Stahl
Jonathan M. Meyer
Affiliation:
University of California, San Diego
Stephen M. Stahl
Affiliation:
University of California, San Diego
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Summary

Clinicians must be knowledgeable about the mechanisms, metabolic pathways, and kinetics of all prescribed medications, but this is especially true for agents with narrower therapeutic indices such as clozapine. Armed with this information, one can maximize the potential for a successful clozapine trial in a patient who may lack other viable therapeutic options. While the properties underlying clozapine’s unique efficacy profile are not fully elucidated, there are extensive data on peripheral and central nervous system (CNS) kinetics, drug–drug and environmental interactions, and plasma levels to inform routine clinical care. (Throughout this volume clozapine plasma levels will be presented in ng/ml and nmol/l units. Some laboratories may report levels in μg/l, which is exactly equivalent to ng/ml.)

Type
Chapter
Information
The Clozapine Handbook
Stahl's Handbooks
 , pp. 90 - 113
Publisher: Cambridge University Press
Print publication year: 2019

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