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7 - Atherosclerosis among the Elites

A Bioarchaeological Investigation of Seventeenth- to Nineteenth-Century Mummified Human Remains from Palermo, Sicily (Italy) and Vilnius (Lithuania)

from Part I - Evidence from Mummified Tissues

Published online by Cambridge University Press:  31 March 2023

By
Dario Piombino-Mascali ,
Rimantas Jankauskas ,
Albert Zink  and
Stephanie Panzer
Edited by
Michaela Binder ,
Charlotte A. Roberts  and
Daniel Antoine
Michaela Binder
Affiliation:
Novetus GmbH Archaeological Services
Charlotte A. Roberts
Affiliation:
Durham University
Daniel Antoine
Affiliation:
British Museum, London
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Summary

As early as the mid-nineteenth century, tangible evidence of cardiovascular disease (CVD) was found in Egyptian mummies, indicating that these people must have experienced atherosclerosis in the same way as modern humans do (Czermak, 1852; Ruffer, 1921). It has been suggested that the origin of the condition among the Egyptian elites was their diet, given that these people consumed food rich in saturated fat (David et al., 2010). However, we do not possess much data on the non-elite individuals from the Nile Valley, as they could not afford mummification.

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The Bioarchaeology of Cardiovascular Disease , pp. 130 - 144
Publisher: Cambridge University Press
Print publication year: 2023

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References

Abdelfattah, A., Allam, A. H., Wann, L. S., et al. (2013). Atherosclerotic cardiovascular disease in Egyptian women: 1570 BCE–2011 CE. International Journal of Cardiology, 167, 570–4.CrossRefGoogle ScholarPubMed
Allam, A. H., Thompson, R. C., Wann, L. S., Miyamoto, M. I. and Thomas, G. S. (2009). Computed tomographic assessment of atherosclerosis in ancient Egyptian mummies. Journal of the American Medical Association, 302(19), 2091–4.Google ScholarPubMed
Allam, A. H., Thompson, R. C., Wann, L. S., et al. (2011). Atherosclerosis in ancient Egyptian mummies: The Horus study. Journal of the American College of Cardiology Cardiovascular Imaging, 4(4), 315–27.Google ScholarPubMed
Allison, M. A., Criqui, M. H. and Wright, C. M. (2004). Patterns and risk factors for systemic calcified atherosclerosis. Arteriosclerosis, Thrombosis and Vascular Biology, 24, 331–6.CrossRefGoogle ScholarPubMed
Al-Mamari, A. (2009). Atherosclerosis and physical activity. Oman Medical Journal, 24(3), 173–8.Google ScholarPubMed
Aufderheide, A. C. (2003). The Scientific Study of Mummies. Cambridge: Cambridge University Press.Google Scholar
Aufderheide, A. C. and Rodríguez Martín, C. (1998). The Cambridge Encyclopedia of Human Paleopathology. Cambridge: Cambridge University Press.Google Scholar
Avellone, G., Di Garbo, V., Campisi, D., et al. (2006). Effects of moderate Sicilian red wine consumption on inflammatory biomarkers of atherosclerosis. European Journal of Clinical Nutrition, 60, 41–7.Google Scholar
Badarienė, J., Petrikonytė, D., Ryliškyte, L. and Šerpytis, P. (2016). ‘Lithuanian’ mutation finally found in Lithuania. American Journal of Medicine, 129(6), e13–14.CrossRefGoogle ScholarPubMed
Boon, A., Cheriex, E., Lodder, J. and Kessels, F. (1997). Cardial valve calcification: Characteristics of patients with calcification of the mitral annulus or aortic valve. Heart, 78, 472–4.Google Scholar
Buscemi, S., Nicolucci, A., Lucisano, G., et al. (2014). Habitual fish intake and clinically silent carotid atherosclerosis. Nutrition Journal, 13, 2.Google Scholar
Campen, M. J., Lund, A. K., Doyle-Eisele, M. L., et al. (2010). A comparison of vascular effects from complex and individual air pollutants indicates a role for monoxide gases and volatile hydrocarbons. Environmental Health Perspectives, 118(7), 921–7.CrossRefGoogle ScholarPubMed
Cardin, M. (2014). Mummies Around the World: An Encyclopedia of Mummies in History, Religion, and Popular Culture. Santa Barbara, CA: ABC Clio.CrossRefGoogle Scholar
Charlier, P., Wils, P., Froment, A. and Huynh-Charlier, I. (2014). Arterial calcifications from mummified materials: Use of micro-CT scan for histological differential diagnosis. Forensic Science, Medicine and Pathology, 10, 461–5.CrossRefGoogle ScholarPubMed
Charlton, A. (2004). Medical uses of tobacco in history. Journal of the Royal Society of Medicine, 92, 292–6.Google Scholar
Cox, M. (2000). Ageing adults from the skeleton. In Cox, M. and Mays, S., eds., Human Osteology in Archaeology and Forensic Science. London: Greenwich Medical Media, pp. 61–82.Google Scholar
Czermak, J. N. (1852). Beschreibung und mikroskopische Untersuchung zweierägyptischer Mumien. Sitzungsberichte der Akademie der Wissenschaften Mathematisch-Naturwissenschaftliche Klasse, 9, 427–69.Google Scholar
David, A.R., Kershaw, A. and Heagerty, A. (2010). Atherosclerosis and diet in ancient Egypt. Lancet, 375, 718–19.CrossRefGoogle ScholarPubMed
Duggan, A. T., Perdomo, M. F., Piombino-Mascali, D., et al. (2016). Seventeenth century variola virus reveals the recent history of smallpox. Current Biology, 26(24), 3407–12.CrossRefGoogle Scholar
Finch, C. E. (2010). Evolution of the human lifespan and diseases of ageing: Roles of infection, inflammation, and nutrition. Proceedings of the National Academy of Sciences USA, 107(Suppl 1), 1718–24.CrossRefGoogle ScholarPubMed
Fornaciari, G. (2008). Food and disease at the Renaissance courts of Naples and Florence: A paleonutritional study. Appetite, 51(1), 11–14.CrossRefGoogle Scholar
Forster, G. (1988). Laiškai iš Vilniaus. Vilnius: Mokslas.Google Scholar
Frick, D. (2013). Kith, Kin, and Neighbors: Communities and Confessions in Seventeenth-century Wilno. Ithaca, NY: Cornell University Press.Google Scholar
Gaeta, R., Giuffra, V. and Fornaciari, G. (2013). Atherosclerosis in the Renaissance elite: Ferdinand I King of Naples (1431–1494). Virchows Archiv, 462, 593–5.Google Scholar
Gaeta, R., Ventura, L. and Fornaciari, G. (2018). Atherosclerosis in the Italian mummies (Fifteenth–twentieth century). Pathologica, 110(3), 159–60.Google Scholar
Giffin, K., Lankapalli, A. K., Sabin, S., et al. (2020). A treponemal genome from an historic plague victim supports a recent emergence of yaws and its presence in fifteenth century Europe. Scientific Reports, 10, 9499.CrossRefGoogle Scholar
Gostner, P., Pernter, P., Bonatti, G., Graefen, A. and Zink, A. R. (2011). New radiological insights into the life and death of the Tyrolean Iceman. Journal of Archaeological Sciences, 38, 3425–31.Google Scholar
Gulati, A., Chan, C., Duncan, A., et al. (2011). Multimodality cardiac imaging in the evaluation of mitral annular caseous calcification. Circulation, 123, e1–2.Google Scholar
Kaplan, H., Thompson, R. C., Trumble, B. C., et al. (2017). Coronary atherosclerosis in indigenous South American Tsimane: A cross-sectional cohort study. Lancet, 389, 1730–9.Google Scholar
Keller, A., Graefen, A., Ball, M., et al. (2012). New insights into the Tyrolean Iceman’s origin and phenotype as inferred by whole-genome sequencing. Nature Communications, 3, 698.CrossRefGoogle ScholarPubMed
Ketonen, J., Merasto, S., Paakkari, I. and Mervaala, E. M. A. (2005). High sodium intake increases vascular superoxide formation and promotes atherosclerosis in apolipoprotein E-deficient mice. Blood Pressure, 14(6), 373–82.CrossRefGoogle ScholarPubMed
Kiechl, S., Willeit, J., Rungger, G., et al. (1998). Alcohol consumption and atherosclerosis: What is the relation? Prospective results from the Brunek study. Stroke, 29, 900–7.Google Scholar
Kristenson, M., Lassvik, C., Bergdahl, B., et al. (2000). Ultrasound determined carotid and femoral atherosclerosis in Lithuanian and Swedish men: The LiVicordia study. Atherosclerosis, 151, 501–8.Google Scholar
Laucevičius, A., Rinkūnienė, E., Ryliškyte, L., et al. (2019). Primary prevention strategy for cardiovascular disease in Lithuania. Seminars in Cardiovascular Medicine, 25, 14–39.CrossRefGoogle Scholar
McMahan, C. A., Gidding, S. S., Malcom, C. T., et al. (2006). Pathobiological determinants of atherosclerosis in youth risk scores are associated with early and advanced atherosclerosis. Pediatrics, 118(4), 1447–55.CrossRefGoogle ScholarPubMed
McPherson, R. (2007). A common allele on chromosome 9 associated with coronary heart disease. Science, 316, 1488–91.CrossRefGoogle ScholarPubMed
Marson, P., Zanchin, G. and Stefanutti, C. (2004). Some historical considerations on the inflammatory theory of atherosclerosis. Reumatismo, 56(3), 215–19.Google ScholarPubMed
Martin, R. (1988). Anthropologie: Handbuch der Vergleichenden Biologie des Menschen. Stuttgart: Gustav Fisher Verlag, Band I, pp. 421–43.Google Scholar
Munizaga, J., Allison, M. J. and Paredes, C. (1978). Cholelithiasis and cholecystitis in pre-Columbian Chileans. American Journal of Physical Anthropology, 48(2), 209–12.CrossRefGoogle ScholarPubMed
Murphy, W. A. Jr, zur Nedden, D., Gostner, P., et al. (2003). The Iceman: Discovery and imaging. Radiology, 226, 614–29.Google Scholar
Murray, R. P., Connett, J. E., Tyas, S. L., et al. (2002). Alcohol volume, drinking pattern, and cardiovascular disease morbidity and mortality: Is there a U-shaped function? American Journal of Epidemiology, 155, 242–8.Google Scholar
Musshoff, F., Brockmann, C., Madea, B., Rosendahl, W. and Piombino-Mascali, D. (2013). Ethyl glucuronide findings in hair samples of the Capuchin Catacombs of Palermo. Forensic Science International, 232, 213–17.CrossRefGoogle ScholarPubMed
O’Brien, J. J., Battista, J. J., Romagnoli, C. and Chhem, R. K. (2009) CT imaging of human mummies: A critical review of the literature (1979–2005). International Journal of Osteoarchaeology, 19, 90–8.Google Scholar
O’Keefe, J. H. Jr and Cordain, L. (2004). Cardiovascular disease resulting from a diet and lifestyle at odds with our Paleolithic genome: How to become a twenty-first century hunter-gatherer. Mayo Clinic Proceedings, 79, 101–8.Google Scholar
Panzer, S., Zink, A. R. and Piombino-Mascali, D. (2010). Radiologic evidence of anthropogenic mummification in the Capuchin Catacombs of Palermo, Sicily. Radiographics, 30(4), 1123–32.Google Scholar
Panzer, S., Augat, P., Zink, A. R. and Piombino-Mascali, D. (2018). CT checklist and scoring system for the assessment of soft tissue preservation in human mummies: application to catacomb mummies from Palermo, Sicily. International Journal of Paleopathology, 20, 50–9.CrossRefGoogle ScholarPubMed
Pepalytė, I., Kučinskienė, Z. A., Grigalionenė, K., et al. (2012). Genetic variants that participate in oxidation processes and/or oxidative stress and are associated with atherosclerosis. European Medicine, Health and Pharmacology Journal, 3, 13–16.Google Scholar
Piombino-Mascali, D. (2017). The lovely bones: Capuchin catacombs of Palermo. In Rodríguez-Maffiotte Martín, C., ed., Athanatos. Inmortal. Muerte e inmortalidad en poblaciones del pasado. Tenerife: Cabildo de Tenerife, pp. 127–31.Google Scholar
Piombino-Mascali, D. (2018). Le Catacombe dei Cappuccini: Guida storico-scientifica. Palermo: Kalós.Google Scholar
Piombino-Mascali, D. and Gill-Frerking, H. (2019). The mummy autopsy: Some ethical considerations. In Squires, K., Errikson, D. and Márquez-Grant, N., eds., Ethical Approaches to Human Remains. Cham, Switzerland: Springer, pp. 605–25.Google Scholar
Piombino-Mascali, D., Jankauskas, R., Tamošiūnas, A., et al. (2014). Atherosclerosis in mummified human remains from Vilnius, Lithuania (eighteenth–nineteenth centuries AD): A computed tomographic investigation. American Journal of Human Biology, 26(5), 676–81.CrossRefGoogle Scholar
Piombino-Mascali, D., Jankauskas, R., Tamošiūnas, A., et al. (2015). Evidence of probable tuberculosis in Lithuanian mummies. Homo, 66(5), 420–31.Google Scholar
Prasad, K. (2009). Flaxseed and cardiovascular health. Journal of Cardiovascular Pharmacology, 54(5), 369–77.Google Scholar
Reitsema, L. J., Kozłowski, T., Jankauskas, R., Drążkowska, A. and Krajewska, M. (2015). Dieta przedstawicieli elit społecznych Rzeczypospolitej na podstawie analizy stabilnych izotopów węgla i azotu w szczątkach szkieletowych. In Drążkowska, A., ed., Kultura funeralna elit Rzeczpospolitej od XVI do XVIII wieku na terenie Korony i Wielkiego Księstwa Litewskiego. Próba analizy interdyscyplinarnej. Toruń: Wydawnictwo Naukowe Uniwersytetu Mikołaja Kopernika, pp. 230–45.Google Scholar
Ridker, P. M. (2002). On evolutionary biology, inflammation, infection, and the causes of atherosclerosis. Circulation, 105, 2–4.CrossRefGoogle ScholarPubMed
Roberts, R., Marian, A. J., Dandona, S. and Stewart, A. F. T. (2012). Genomics in cardiovascular disease. Journal of the American College of Cardiology, 64, 2029–37.Google Scholar
Rodgers, J. L., Jones, J., Bolleddu, S. I., et al. (2019). Cardiovascular risks associated with gender and aging. Journal of Cardiovascular Development and Disease, 6(2), 19.Google Scholar
Ruffer, M. A. (1921). Studies in the Palaeopathology of Egypt. Chicago: University of Chicago Press.Google Scholar
Rühli, F. J., Chhem, R. K. and Böni, T. (2004). Diagnostic paleoradiology of mummified tissue: interpretation and pitfalls. Canadian Association of Radiologists Journal, 55(4), 218–27.Google Scholar
Santoro, D. (2013). Salute dei re, salute del popolo: Mangiare e curarsi nella Sicilia tardomedievale. Anuario de Estudios Medievales, 43(1), 259–89.CrossRefGoogle Scholar
Sarti, R. (2003). Vita di casa: Abitare, mangiare, vestire nell’Europa moderna. Roma-Bari: Laterza.Google Scholar
Stary, H. C., Chandler, A. B., Dinsmore, R. E., et al. (1995). A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis: A report from the Committee on Vascular Lesions of the Council on Atherosclerosis, American Heart Association. Arteriosclerosis, Thrombosis and Vascular Biology, 92, 1355–74.Google Scholar
Strong, J. P., Malcom, G. T., McMahan, C. A., et al. (1999). Prevalence and extent of atherosclerosis in adolescents and young adults: Implications for prevention from the pathobiological determinants of atherosclerosis in Youth Study. Journal of the American Medical Association, 281, 727–35.Google Scholar
Thompson, R. C., Allam, A. H., Lombardi, G. P., et al. (2013). Atherosclerosis across 4000 years of human history: The Horus study of four ancient populations. Lancet, 381, 1211–22.Google Scholar
Widmer, R. J., Flammer, A. J., Lerman, L. O. and Lerman, A. (2015). The Mediterranean diet, its components, and cardiovascular disease. American Journal of Medicine, 128(3), 229–38.Google Scholar
Zimmerman, M. R. (1993). The paleopathology of the cardiovascular system. Texas Heart Institute Journal, 20, 252–7.Google ScholarPubMed

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