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Chapter 47 - Blood–Brain Barrier

from Section 4 - Neurophysiology

Published online by Cambridge University Press:  31 July 2019

David Chambers ,
Christopher Huang  and
Gareth Matthews
David Chambers
Affiliation:
Salford Royal NHS Foundation Trust
Christopher Huang
Affiliation:
University of Cambridge
Gareth Matthews
Affiliation:
University of Cambridge
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Summary

The blood–brain barrier (BBB) is a physiological, cellular and metabolic barrier at the level of the cerebral capillaries. Their permeability properties restrict the free movement of substances between the capillaries and the extracellular fluid (ECF) of the brain. The BBB has several functions.

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Basic Physiology for Anaesthetists , pp. 200 - 201
Publisher: Cambridge University Press
Print publication year: 2019

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References

Further reading

Daneman, R., Prat, A.. The blood–brain barrier. Cold Spring Harb Perspect Biol 2015; 7(1): a020412.Google Scholar
Tajes, M., Ramos-Fernández, E., Weng-Jiang, X., et al. The blood–brain barrier: structure, function and therapeutic approaches to cross it. Mol Membr Biol 2014; 31(5): 152–67.CrossRefGoogle Scholar
Daneman, R.. The blood–brain barrier in health and disease. Ann Neurol 2012; 72(5): 648–72.CrossRefGoogle ScholarPubMed
Lawther, B. K., Kumar, S., Krovvindi, H.. Blood brain barrier. Continuing Educ Anaesth Crit Care Pain 2011; 11(4): 128–32.CrossRefGoogle Scholar

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