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Impact of obesity on medically assisted reproductive treatments

Published online by Cambridge University Press:  16 March 2022

Romualdo Sciorio Open the ORCID record for Romualdo Sciorio [Opens in a new window] ,
Serena Bellaminutti ,
Luca Tramontano  and
Sandro C. Esteves
Romualdo Sciorio*
Affiliation:
Edinburgh Assisted Conception Programme, EFREC, Royal Infirmary of Edinburgh, UK
Serena Bellaminutti
Affiliation:
Department of Women, Infants and Adolescents, Division of Obstetrics, Geneva University Hospitals, Boulevard de la Cluse 30, 1211 Genève 14, Switzerland
Luca Tramontano
Affiliation:
Department of Women, Infants and Adolescents, Division of Obstetrics, Geneva University Hospitals, Boulevard de la Cluse 30, 1211 Genève 14, Switzerland
Sandro C. Esteves
Affiliation:
ANDROFERT, Andrology and Human Reproduction Clinic, Campinas, Brazil Department of Surgery (Division of Urology), University of Campinas (Brazil) Faculty of Health, Aarhus University, Aarhus, Denmark
*
Author for correspondence: Romualdo Sciorio. Edinburgh Assisted Conception Programme, EFREC, Royal Infirmary of Edinburgh, UK. E-mail: [email protected]
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Summary

Increasing evidence has demonstrated that obesity impairs female fertility and negatively affects human reproductive outcome following medically assisted reproduction (MAR) treatment. In the United States, 36.5% of women of reproductive age are obese. Obesity results not only in metabolic disorders including type II diabetes and cardiovascular disease, but might also be responsible for chronic inflammation and oxidative stress. Several studies have demonstrated that inflammation and reactive oxygen species (ROS) in the ovary modify steroidogenesis and might induce anovulation, as well as affecting oocyte meiotic maturation, leading to impaired oocyte quality and embryo developmental competence. Although the adverse effect of female obesity on human reproduction has been an object of debate in the past, there is growing evidence showing a link between female obesity and increased risk of infertility. However, further studies need to clarify some gaps in knowledge. We reviewed the recent evidence on the association between female obesity and infertility. In particular, we highlight the association between fat distribution and reproductive outcome, and how the inflammation and oxidative stress mechanisms might reduce ovarian function and oocyte quality. Finally, we evaluate the connection between female obesity and endometrial receptivity.

Keywords

Embryo competenceIn vitro embryo developmentInfertilityObesityOocyte qualityReproductive health
Type
Review Article
Information
Zygote , Volume 30 , Issue 4 , August 2022 , pp. 431 - 439
Copyright
© The Author(s), 2022. Published by Cambridge University Press

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