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The effects of the day of trophectoderm biopsy and blastocyst grade on the clinical and neonatal outcomes of preimplantation genetic testing–frozen embryo transfer cycles

Published online by Cambridge University Press:  28 June 2021

Linjun Chen Open the ORCID record for Linjun Chen [Opens in a new window] ,
Zhenyu Diao ,
Jie Wang ,
Zhipeng Xu ,
Ningyuan Zhang ,
Junshun Fang  and
Fei Lin
Linjun Chen*
Affiliation:
Reproductive Medical Center, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Zhongshan Road 321#, Nanjing210008, People’s Republic of China Center for Molecular Reproductive Medicine, Nanjing University, Nanjing210008, People’s Republic of China
Zhenyu Diao
Affiliation:
Reproductive Medical Center, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Zhongshan Road 321#, Nanjing210008, People’s Republic of China Center for Molecular Reproductive Medicine, Nanjing University, Nanjing210008, People’s Republic of China
Jie Wang
Affiliation:
Reproductive Medical Center, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Zhongshan Road 321#, Nanjing210008, People’s Republic of China Center for Molecular Reproductive Medicine, Nanjing University, Nanjing210008, People’s Republic of China
Zhipeng Xu
Affiliation:
Reproductive Medical Center, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Zhongshan Road 321#, Nanjing210008, People’s Republic of China Center for Molecular Reproductive Medicine, Nanjing University, Nanjing210008, People’s Republic of China
Ningyuan Zhang
Affiliation:
Reproductive Medical Center, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Zhongshan Road 321#, Nanjing210008, People’s Republic of China Center for Molecular Reproductive Medicine, Nanjing University, Nanjing210008, People’s Republic of China
Junshun Fang
Affiliation:
Reproductive Medical Center, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Zhongshan Road 321#, Nanjing210008, People’s Republic of China Center for Molecular Reproductive Medicine, Nanjing University, Nanjing210008, People’s Republic of China
Fei Lin*
Affiliation:
Reproductive Medical Center, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Zhongshan Road 321#, Nanjing210008, People’s Republic of China Center for Molecular Reproductive Medicine, Nanjing University, Nanjing210008, People’s Republic of China
*
Authors for correspondence: Linjun Chen. Reproductive Medical Center, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Zhongshan Road 321#, Nanjing210008, People’s Republic of China. Email: [email protected]
Fei Lin. Reproductive Medical Center, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Zhongshan Road 321#, Nanjing210008, People’s Republic of China. Email: [email protected]
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Summary

This study analyzed the effects of the day of trophectoderm (TE) biopsy and blastocyst grade on clinical and neonatal outcomes. The results showed that the implantation and live birth rates of day 5 (D5) TE biopsy were significantly higher compared with those of D6 TE biopsy. The miscarriage rate of the former was lower than that of the latter, but there was no statistically significant difference. Higher quality blastocysts can achieve better implantation and live birth rates. Among good quality blastocysts, the implantation and live birth rates of D5 and D6 TE biopsy were not significantly different. Among fair quality and poor quality blastocysts, the implantation and live birth rates of D5 TE biopsy were significantly higher compared with those of D6 TE biopsy. Neither blastocyst grade nor the day of TE biopsy significantly affected the miscarriage rate. Neonatal outcomes, including newborn sex, gestational age, preterm birth, birth weight and low birth weight in the D5 and D6 TE biopsies were not significantly different. Both blastocyst grade and the day of TE biopsy must be considered at the same time when performing preimplantation genetic testing–frozen embryo transfer.

Keywords

Clinical outcomesFETNeonatal outcomesPGTTrophectoderm biopsy
Type
Research Article
Information
Zygote , Volume 30 , Issue 1 , February 2022 , pp. 132 - 137
Copyright
© The Author(s), 2021. Published by Cambridge University Press

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