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Saccadic inhibition among schizotypal personality disorder subjects

Published online by Cambridge University Press:  30 April 2001

COLLEEN A. BRENNER ,
JENNIFER E. McDOWELL ,
KRISTIN S. CADENHEAD  and
BRETT A. CLEMENTZ
COLLEEN A. BRENNER
Affiliation:
Department of Psychology, Indiana University, Bloomington, USA
JENNIFER E. McDOWELL
Affiliation:
Department of Psychiatry, University of California, San Diego, USA
KRISTIN S. CADENHEAD
Affiliation:
Department of Psychiatry, University of California, San Diego, USA
BRETT A. CLEMENTZ
Affiliation:
Department of Psychology, University of California, San Diego, USA
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Abstract

Schizotypal personality disorder (SPD) is theoretically part of the schizophrenia spectrum both clinically and neurobiologically. A liability for developing schizophrenia may be associated with dysfunction of dorsolateral prefrontal cortex (DLPFC) and its cortical and/or subcortical circuitry. If so, abnormalities on tasks associated with DLPFC functioning among SPD subjects would support the thesis that SPD is neurobiologically related to schizophrenia. Antisaccade and ocular motor delayed response performance, both of which are ostensibly supported by DLPFC circuitry, were assessed among 29 SPD, 17 schizophrenia, and 25 normal subjects. Generally, the SPD subjects' performance was more similar to normal than to schizophrenia groups. There was evidence, however, for inhibition abnormalities in a subgroup of SPD subjects. Antisaccade performance identified more SPD subjects as “abnormal” than delayed response measures.

Keywords

Schizotypal personality disorderSchizophrenia spectrumSaccadeAntisaccadeMemory saccadeVulnerability markers
Type
Research Article
Information
Psychophysiology , Volume 38 , Issue 3 , May 2001 , pp. 399 - 403
Copyright
2001 Society for Psychophysiological Research

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