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Implication of reward alterations in the expression of negative symptoms in 22q11.2 deletion syndrome: a behavioural and DTI study

Published online by Cambridge University Press:  23 January 2017

L. Dubourg ,
M. Schneider ,
M. C. Padula ,
L. Chambaz ,
M. Schaer  and
S. Eliez
L. Dubourg*
Affiliation:
Department of Psychiatry, Office Médico-Pédagogique Research Unit, School of Medicine, University of Geneva, Geneva, Switzerland
M. Schneider
Affiliation:
Department of Psychiatry, Office Médico-Pédagogique Research Unit, School of Medicine, University of Geneva, Geneva, Switzerland Department of Neuroscience, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium
M. C. Padula
Affiliation:
Department of Psychiatry, Office Médico-Pédagogique Research Unit, School of Medicine, University of Geneva, Geneva, Switzerland
L. Chambaz
Affiliation:
Department of Psychiatry, Office Médico-Pédagogique Research Unit, School of Medicine, University of Geneva, Geneva, Switzerland
M. Schaer
Affiliation:
Department of Psychiatry, Office Médico-Pédagogique Research Unit, School of Medicine, University of Geneva, Geneva, Switzerland Stanford Cognitive and Systems Neuroscience Laboratory, Stanford University, Stanford, CA, USA
S. Eliez
Affiliation:
Department of Psychiatry, Office Médico-Pédagogique Research Unit, School of Medicine, University of Geneva, Geneva, Switzerland Department of Genetic Medicine and Development, School of Medicine, University of Geneva, Geneva, Switzerland
*
*Address for correspondence: L. Dubourg, MSc, Office-médico-pédagogique, Rue David-Dufour 1, 1205 Geneva, Switzerland. (Email: [email protected])
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Abstract

Background

Alterations of the reward system have been proposed as one of the core mechanisms underlying the expression of negative symptoms in schizophrenia. Specifically, deficits in specific reward components and white matter (WM) integrity of the reward system have been highlighted. The putative link between negative symptoms and the hedonic experience, or structural connectivity of the reward system has never been examined in the 22q11.2 deletion syndrome (22q11DS), a condition with increased risk for psychosis.

Method

Anticipatory and consummatory dimensions of pleasure were assessed in participants with 22q11DS (N = 54) and healthy controls (N = 55). In patients with 22q11DS, the association between pleasure scores and positive or negative symptoms was investigated. Furthermore, WM integrity of the accumbofrontal tract was quantified using diffusion tensor imaging (DTI). Associations between DTI measures, pleasure dimensions and negative symptoms were examined.

Results

Patients with 22q11DS showed reduced anticipatory and consummatory pleasure compared to controls. Furthermore, anticipatory pleasure scores were negatively correlated to negative and positive symptoms in 22q11DS. WM microstructural changes of the accumbofrontal tract in terms of increased fractional anisotropy and reduced radial anisotropy were also identified in patients. However, no significant correlation between the DTI measures and pleasure dimensions or psychotic symptoms was observed.

Conclusions

This study revealed that participants with 22q11DS differed in their experience of pleasure compared to controls. The anticipatory pleasure component appears to be related to negative and positive symptom severity in patients. Alterations of WM integrity of the accumbofrontal tract seem to be related to myelination abnormalities in 22q11DS patients.

Keywords

22q11.2 deletion syndromenegative symptomsreward systemwhite matter
Type
Original Articles
Information
Psychological Medicine , Volume 47 , Issue 8 , June 2017 , pp. 1442 - 1453
Copyright
Copyright © Cambridge University Press 2017 

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