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Evidence for default mode network dysfunction in borderline personality disorder

Published online by Cambridge University Press:  28 August 2019

Salvatore Aguilar-Ortiz ,
Pilar Salgado-Pineda ,
Daniel Vega ,
Juan C. Pascual ,
Josep Marco-Pallarés ,
Joaquim Soler ,
Cristina Brunel ,
Ana Martin-Blanco ,
Angel Soto  and
Joan Ribas
...Show all authors
Salvatore Aguilar-Ortiz
Affiliation:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain Benito Menni Complex Assistencial en Salut Mental, Sant Boi de Llobregat, Barcelona, Spain Departament de Psiquiatria i Medicina Legal, PhD Programme, Doctorat en Psiquiatria, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
Pilar Salgado-Pineda
Affiliation:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain CIBERSAM, Barcelona, Spain
Daniel Vega
Affiliation:
Servei de Psiquiatria i Salut Mental, Consorci Sanitari de l'Anoia, Igualada, Spain
Juan C. Pascual
Affiliation:
CIBERSAM, Barcelona, Spain Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Josep Marco-Pallarés
Affiliation:
Faculty of Psychology, University of Barcelona, Bellvitge Hospital, Barcelona, Spain
Joaquim Soler
Affiliation:
CIBERSAM, Barcelona, Spain Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Cristina Brunel
Affiliation:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain Benito Menni Complex Assistencial en Salut Mental, Sant Boi de Llobregat, Barcelona, Spain
Ana Martin-Blanco
Affiliation:
Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Angel Soto
Affiliation:
Servei de Psiquiatria i Salut Mental, Consorci Sanitari de l'Anoia, Igualada, Spain
Joan Ribas
Affiliation:
Servei de Psiquiatria i Salut Mental, Consorci Sanitari de l'Anoia, Igualada, Spain
Teresa Maristany
Affiliation:
Hospital Sant Joan de Déu, Esplugues de Llobregrat, Barcelona, Spain
Salvador Sarró
Affiliation:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain CIBERSAM, Barcelona, Spain
Antoni Rodríguez-Fornells
Affiliation:
Faculty of Psychology, University of Barcelona, Bellvitge Hospital, Barcelona, Spain
Raymond Salvador
Affiliation:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain CIBERSAM, Barcelona, Spain
Peter J. McKenna*
Affiliation:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain CIBERSAM, Barcelona, Spain
Edith Pomarol-Clotet
Affiliation:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain CIBERSAM, Barcelona, Spain
*
Author for correspondence: Peter J. Mckenna, Email: [email protected]
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Abstract

Background

Although executive and other cognitive deficits have been found in patients with borderline personality disorder (BPD), whether these have brain functional correlates has been little studied. This study aimed to examine patterns of task-related activation and de-activation during the performance of a working memory task in patients with the disorder.

Methods

Sixty-seven DSM-IV BPD patients and 67 healthy controls underwent fMRI during the performance of the n-back task. Linear models were used to obtain maps of within-group activations and areas of differential activation between the groups.

Results

On corrected whole-brain analysis, there were no activation differences between the BPD patients and the healthy controls during the main 2-back v. baseline contrast, but reduced activation was seen in the precentral cortex bilaterally and the left inferior parietal cortex in the 2-back v. 1-back contrast. The patients showed failure of de-activation affecting the medial frontal cortex and the precuneus, plus in other areas. The changes did not appear to be attributable to previous history of depression, which was present in nearly half the sample.

Conclusions

In this study, there was some, though limited, evidence for lateral frontal hypoactivation in BPD during the performance of an executive task. BPD also appears to be associated with failure of de-activation in key regions of the default mode network.

Keywords

Borderline personality disorderdefault mode networkfunctional imagingneuroimaging
Type
Original Articles
Information
Psychological Medicine , Volume 50 , Issue 10 , July 2020 , pp. 1746 - 1754
Copyright
Copyright © Cambridge University Press 2019

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