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Dissociable patterns of medial prefrontal and amygdala activity to face identity versus emotion in bipolar disorder

Published online by Cambridge University Press:  25 January 2012

M. T. Keener ,
J. C. Fournier ,
B. C. Mullin ,
D. Kronhaus ,
S. B. Perlman ,
E. LaBarbara ,
J. C. Almeida  and
M. L. Phillips
M. T. Keener*
Affiliation:
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J. C. Fournier
Affiliation:
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
B. C. Mullin
Affiliation:
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
D. Kronhaus
Affiliation:
Institute for Adaptive and Neural Computation, School of Informatics, The University of Edinburgh, Edinburgh, UK Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK
S. B. Perlman
Affiliation:
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
E. LaBarbara
Affiliation:
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J. C. Almeida
Affiliation:
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
M. L. Phillips
Affiliation:
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Department of Psychological Medicine, Cardiff University, Cardiff, UK
*
*Address for correspondence: M. T. Keener, M.D., Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Loeffler Building Room 202, 121 Meyran Avenue, Pittsburgh, PA 15213, USA. (Email: [email protected])
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Abstract

Background

Individuals with bipolar disorder demonstrate abnormal social function. Neuroimaging studies in bipolar disorder have shown functional abnormalities in neural circuitry supporting face emotion processing, but have not examined face identity processing, a key component of social function. We aimed to elucidate functional abnormalities in neural circuitry supporting face emotion and face identity processing in bipolar disorder.

Method

Twenty-seven individuals with bipolar disorder I currently euthymic and 27 healthy controls participated in an implicit face processing, block-design paradigm. Participants labeled color flashes that were superimposed on dynamically changing background faces comprising morphs either from neutral to prototypical emotion (happy, sad, angry and fearful) or from one identity to another identity depicting a neutral face. Whole-brain and amygdala region-of-interest (ROI) activities were compared between groups.

Results

There was no significant between-group difference looking across both emerging face emotion and identity. During processing of all emerging emotions, euthymic individuals with bipolar disorder showed significantly greater amygdala activity. During facial identity and also happy face processing, euthymic individuals with bipolar disorder showed significantly greater amygdala and medial prefrontal cortical activity compared with controls.

Conclusions

This is the first study to examine neural circuitry supporting face identity and face emotion processing in bipolar disorder. Our findings of abnormally elevated activity in amygdala and medial prefrontal cortex (mPFC) during face identity and happy face emotion processing suggest functional abnormalities in key regions previously implicated in social processing. This may be of future importance toward examining the abnormal self-related processing, grandiosity and social dysfunction seen in bipolar disorder.

Keywords

Affective disordersamygdalabipolar disorderface processingfunctional magnetic resonance imagingidentity processingmedial prefrontal cortexmorphself-processingsocial processing
Type
Original Articles
Information
Psychological Medicine , Volume 42 , Issue 9 , September 2012 , pp. 1913 - 1924
Copyright
Copyright © Cambridge University Press 2012

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