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Evidence that hippocampal–parahippocampal dysfunction is related to genetic risk for schizophrenia

Published online by Cambridge University Press:  31 October 2012

A. Di Giorgio ,
B. Gelao ,
G. Caforio ,
R. Romano ,
I. Andriola ,
E. D'Ambrosio ,
A. Papazacharias ,
F. Elifani ,
L. Lo Bianco  and
P. Taurisano
...Show all authors
A. Di Giorgio
Affiliation:
IRCCS ‘Casa Sollievo della Sofferenza’, San Giovanni Rotondo, Foggia, Italy
B. Gelao
Affiliation:
Psychiatric Neuroscience Group, Department of Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, Bari, Italy
G. Caforio
Affiliation:
Psychiatric Neuroscience Group, Department of Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, Bari, Italy
R. Romano
Affiliation:
Psychiatric Neuroscience Group, Department of Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, Bari, Italy
I. Andriola
Affiliation:
Psychiatric Neuroscience Group, Department of Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, Bari, Italy
E. D'Ambrosio
Affiliation:
Psychiatric Neuroscience Group, Department of Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, Bari, Italy
A. Papazacharias
Affiliation:
Psychiatric Neuroscience Group, Department of Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, Bari, Italy
F. Elifani
Affiliation:
Psychiatric Neuroscience Group, Department of Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, Bari, Italy
L. Lo Bianco
Affiliation:
Psychiatric Neuroscience Group, Department of Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, Bari, Italy Psychiatric Unit, Department of Mental Health, United Hospitals of Ancona, Polytechnic University of Marche, Italy
P. Taurisano
Affiliation:
Psychiatric Neuroscience Group, Department of Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, Bari, Italy
L. Fazio
Affiliation:
Psychiatric Neuroscience Group, Department of Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, Bari, Italy
T. Popolizio
Affiliation:
IRCCS ‘Casa Sollievo della Sofferenza’, San Giovanni Rotondo, Foggia, Italy
G. Blasi
Affiliation:
Psychiatric Neuroscience Group, Department of Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, Bari, Italy
A. Bertolino*
Affiliation:
IRCCS ‘Casa Sollievo della Sofferenza’, San Giovanni Rotondo, Foggia, Italy Psychiatric Neuroscience Group, Department of Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, Bari, Italy
*
*Address for correspondence: A. Bertolino, M.D., Ph.D., Dipartimento di Neuroscienze ed Organi di Senso, Università degli Studi di Bari ‘Aldo Moro’, Piazza Giulio Cesare, 11, 70124, Bari, Italy. (Email: [email protected])
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Abstract

Background

Abnormalities in hippocampal–parahippocampal (H-PH) function are prominent features of schizophrenia and have been associated with deficits in episodic memory. However, it remains unclear whether these abnormalities represent a phenotype related to genetic risk for schizophrenia or whether they are related to disease state.

Method

We investigated H-PH-mediated behavior and physiology, using blood oxygenation level-dependent functional magnetic resonance imaging (BOLD fMRI), during episodic memory in a sample of patients with schizophrenia, clinically unaffected siblings and healthy subjects.

Results

Patients with schizophrenia and unaffected siblings displayed abnormalities in episodic memory performance. During an fMRI memory encoding task, both patients and siblings demonstrated a similar pattern of reduced H-PH engagement compared with healthy subjects.

Conclusions

Our findings suggest that the pathophysiological mechanism underlying the inability of patients with schizophrenia to properly engage the H-PH during episodic memory is related to genetic risk for the disorder. Therefore, H-PH dysfunction can be assumed as a schizophrenia susceptibility-related phenotype.

Keywords

Genetic riskhippocampusmemoryschizophreniasiblings
Type
Original Articles
Information
Psychological Medicine , Volume 43 , Issue 8 , August 2013 , pp. 1661 - 1671
Copyright
Copyright © Cambridge University Press 2012 

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