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Dilemmas of a Dual-Use Technology: Toxins in Medicine and Warfare

Published online by Cambridge University Press:  17 May 2016

Jonathan B. Tucker*
Affiliation:
Washington, DC, USA

Abstract

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Several toxins are “dual-use” in that they have legitimate therapeutic, pharmaceutical, or scientific applications as well as potential military utility as toxin warfare (TW) agents. The growing peaceful applications of such toxins may complicate efforts to ban their use for warfare or terrorist purposes. Worldwide consumption of toxins for medical therapy and scientific research has increased from a few grams to the current level of hundreds of grams per year, and the projected future growth of toxin therapies will require tens to hundreds of kilograms of material annually, blurring the distinction between medically useful and militarily significant quantities. As a result, a proliferator might seek to acquire an offensive TW capability under the guise of “peaceful” activities permitted by the Biological and Toxin Weapons Convention (BWC) and the Chemical Weapons Convention (CWC). To examine this problem more closely, the case of ricin—a putative toxin warfare agent with expanding scientific and medical applications—is discussed in detail. Finally, an analysis of policy options for regulating dual-use toxins concludes that precise monitoring of toxin production would be impracticable in many cases, and that international efforts to achieve greater openness and transparency offer the most realistic basis for distinguishing between the legitimate and banned uses of toxins.

Type
Dual-Use Toxins
Copyright
Copyright © Association for Politics and the Life Sciences 

References

Atsmon, D. (1989). “Castor.” In Roebbelen, G., Downey, R.K., and Ashri, A. (eds.), Oil Crops of the World: Their Breeding and Utilization. New York: McGraw-Hill.Google Scholar
Balint, G.A. (1974). “Ricin: The Toxin Protein of Castor Oil Seeds.” Toxicology 2:77102.Google Scholar
Conference on Disarmament (1972). “Convention on the Prohibition of the Development, Production and Stockpiling of Bacteriological (Biological) and Toxin Weapons and on Their Destruction.” Reprinted in U.S. Arms Control and Disarmament Agency, Arms Control and Disarmament Agreements: Texts and Histories of the Negotiations. Washington, DC: ACDA, 1990, 133–37.Google Scholar
Conference on Disarmament (1992). “Regime for Schedule 1 Chemicals and Facilities Related to Such Chemicals.” Draft Chemical Weapons Convention. Extracted from CD/1173, paragraphs 10-12, 129.Google Scholar
Conference on Disarmament (1993). “Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on Their Destruction.” Reprinted by the U.S. Arms Control and Disarmament Agency, Washington, DC, October, 1993.Google Scholar
Cookson, J. and Nottingham, J. (1969). A Survey of Chemical and Biological Warfare. New York: Monthly Review Press.Google Scholar
Erlick, B.J. (1990). Testimony, in U.S. Senate, Committee on Governmental Affairs, Global Spread of Chemical and Biological Weapons: Assessing Challenges and Responses. 101st Congress, First Session, Feb. 9, 1989. Washington, DC: U.S. Government Printing Office.Google Scholar
Evangeli, A. (1993). “Botulism Gives Faces a New Lease on Life.” New Scientist 137:18.Google Scholar
External Affairs and International Trade Canada (1991). Novel Toxins and Bioregulators: The Emerging Scientific and Technological Issues Relating to Verification of the Biological and Toxin Weapons Convention. Ottawa: External Affairs, Verification Research Unit.Google Scholar
FitzGerald, D. and Pastan, I. (1989). “Targeted Toxin Therapy for the Treatment of Cancer.” Journal of the National Cancer Institute 81(19):1455–63.Google Scholar
Fodstad, Ø., Johannessen, J.V., Schjerven, L., and Pihl, A. (1979). “Toxicity of Abrin and Ricin in Mice and Dogs.” Journal of Toxicology and Environmental Health 5:1073–84.Google Scholar
Freeman, S. (1990). “Disease as a Weapon of War.” Pacific Research 3 (February):5.Google Scholar
Geissler, E. (1992). “Vaccines for Peace: An International Program of Development and Use of Vaccines Against Dual-Threat Agents.” Politics and the Life Sciences 11:231–43.CrossRefGoogle Scholar
Gilman, A.G. (1990). The Pharmacological Basis of Therapeutics, 8th edition. New York: Pergamon Press.Google Scholar
Government of Australia (1991). “Impact of Recent Advances in Science and Technology on the Biological Weapons Convention.” Third Review Conference of the BWC (Geneva, Switzerland), Document No. BWC/CONF.III/4, August 26:26.Google Scholar
Government of the USSR (1991). “Selected Scientific and Technological Developments of Relevance to the BW Convention.” Third Review Conference of the BWC (Geneva, Switzerland), Document No. BWC/CONF.III/4/Add.1, September 10:412.Google Scholar
Hansen, L.M. (1990). “Biological and Toxin Weapons: Arms Control, Stability, and Western Security.” Politics and the Life Sciences 9:4758Google Scholar
Harris, R. and Paxman, J. (1982). A Higher Form of Killing: The Secret Story of Gas and Germ Warfare. London: Chatto and Windus.Google Scholar
Harsanyi, Z.P. (1992). “Biological Defense and Industry.” In Zilinskas, R.A. (ed.), The Microbiologist and Biological Defense Research: Ethics, Politics and International Security. Annals of the New York Academy of Sciences 666:219–29.Google Scholar
Henderson, D.A. (1992). “Surveillance Systems and Intergovernmental Cooperation.” In Morse, S.S. (ed.), Emerging Viruses. New York: Oxford University Press.Google Scholar
Heneson, N. (1991). “New Clinical Uses for Botulinum Toxin.” American Society for Microbiology News 59(2):6364.Google Scholar
Hertler, A.A. and Frankel, A.E. (1989). “Immunotoxins: A Clinical Review of Their Use in the Treatment of Malignancies.” Journal of Clinical Oncology 7(12):1939.Google Scholar
Knight, B. (1979). “Ricin — A Potent Homicidal Poison.” British Medical Journal 6159:350–51.Google Scholar
Lin, T.T.S. and Li, S.S.L. (1980). “Purification and Physiochemical Properties of Ricins and Agglutinins from Ricinus communis.” European Journal of Biochemistry 105:453–59.Google Scholar
Mariwala, K.V. (1993). Author interview with Kishore V. Mariwala, President, Indian Chemical Manufacturers Association, September, 1993.Google Scholar
Murphy, S., Hay, A., and Rose, S. (1984). No Fire, No Thunder: The Threat of Chemical and Biological Weapons. New York: Monthly Review Press.Google Scholar
Novick, R. and Shulman, S. (1990). “New Forms of Biological Warfare?” In Wright, S. (ed.), Preventing a Biological Arms Race. Cambridge, MA: MIT Press.Google Scholar
Office of Technology Assessment, U.S. Congress (1991). Biotechnology in a Global Economy, OTA-BA-494. Washington, DC: U.S. Government Printing Office.Google Scholar
Office of Technology Assessment, U.S. Congress (1993). Proliferation of Weapons of Mass Destruction: Assessing the Risks, OTA-ISC-559. Washington, DC: U.S. Government Printing Office.Google Scholar
Olsnes, S. (1977). “Abrin and Ricin: Two Toxin Lectins Inactivating Eukaryotic Ribosomes.” In Bernheimer, A.W. (ed.), Perspectives in Toxicology. New York: John Wiley and Sons.Google Scholar
Olsnes, S. and Pihl, A. (1982). “Chimeric Toxins.” Pharmacology and Therapeutics 15(3):355–58.Google Scholar
Osol, A., et al.(1975). Remmington's Pharmaceutical Sciences, 15th edition. Easton, PA: Mack Publishing.Google Scholar
Primrose, S.B. (1991). Molecular Biotechnology, 2nd edition. Oxford: Blackwell Scientific Publications.Google Scholar
Ready, M.P., Kim, Y., and Robertus, J.D. (1991). “Site-Directed Mutagenesis of Ricin A-Chain and Implications for the Mechanism of Action.” Proteins: Structure, Function, and Genetics 10:270–78.Google Scholar
Robertus, J. (1989). “The Three-Dimensional Structure of the Enzymatic Plant Toxin Ricin.” In Ownby, C.L. and Odell, G.V. (eds.), Natural Toxins: Characterization, Pharmacology and Therapeutics. Oxford: Pergamon Press.Google Scholar
Robertus, J.D., Piatak, M., Ferris, R., and Houston, L.L. (1987). “Crystallization of Ricin A Chain Obtained from a Cloned Gene Expressed in Escherichia coli.” Journal of Biological Chemistry 262:1920.Google Scholar
Robinson, J., Guillemin, J., and Meselson, M. (1990). “Yellow Rain in Southeast Asia: The Story Collapses.” In Wright, S. (ed.), Preventing a Biological Arms Race. Cambridge, MA: MIT Press.Google Scholar
Sanches, M., Randolph, C.L., Barden, J.D., Bradley, S., Laughlin, L.L., Leonard, R.D., and Russell, C.R. (1991). Chemical Weapons Convention (CWC) Signatures Analysis. Final Technical Report No. 1396. Arlington, VA: System Planning Corporation.Google Scholar
Schantz, E.J., et al.(1957). “Paralytic Shellfish Poison. IV: A Procedure for the Isolation and Purification of Poison from Toxic Clam and Mussel Tissues.” Journal of the American Chemical Society 79:5230–35.CrossRefGoogle Scholar
Simmons, B.M. and Russell, J.H. (1985). “A Single Affinity Column Step Method for the Purification of Ricin Toxin from Castor Beans (Ricinus communis).” Analytical Biochemistry 146:206–10.Google Scholar
SIPRI [Stockholm International Peace Research Institute] (1971). The Problem of Chemical and Biological Warfare, Vol. I: The Rise of CB Weapons. Stockholm: Almqvist and Wiksell.Google Scholar
Taylor, J. (1993). Author interview with James Taylor, Director of Regulatory Affairs, ImmunoGen (Cambridge, MA), June 21.Google Scholar
ter Haar, B. (1991). The Future of Biological Weapons. The Washington Papers No. 151. New York: Center for Strategic and International Studies/Praeger.Google Scholar
Thorpe, P.E. and Ross, W.C.J. (1982). “The Preparation and Cytotoxic Properties of Antibody-Toxin Conjugates.” Immunological Reviews 62:119–58.Google Scholar
Tucker, J.B. (1984). “Gene Wars.” Foreign Policy 57:5879.Google Scholar
Tucker, J.B. (1992). “The Future of Biological Warfare.” In Wander, W.T. and Arnett, E.H. (eds.), The Proliferation of Advanced Weaponry: Technology, Motivations, and Responses. Washington, DC: American Association for the Advancement of Science.Google Scholar
Tucker, M.E. (1993). “Botulinum Toxin Injection Effective for Achalasia.” Internal Medicine News & Cardiology News 26(17):22.Google Scholar
Ubell, E. (1993). “When Poison Cures.” Parade Magazine (June 13):8.Google Scholar
U.S. Dept. of Defense (1992). Conduct of the Persian Gulf War: Final Report to Congress. Washington, DC: Department of Defense.Google Scholar
U.S. Dept. of State (1982). Chemical Warfare in Southeast Asia and Afghanistan. Special Report No. 98, March 22:30.Google Scholar
U.S. Senate (1993). Committee on Foreign Relations, Subcommittee on Arms Control, Oceans, International Operations, and Environment. Yellow Rain: The Arms Control Implications. 98th Congress, First Session, February 24. Washington, DC: U.S. Government Printing Office.Google Scholar
Vitteta, E.S. and Uhr, J.W. (1984). “The Potential Use of Immunotoxins in Transplantation, Cancer Therapy and Immunoregulation.” Transplantation 37:535.Google Scholar
Waller, D. (1992). “Sneaking in the Scuds.” Newsweek (June 22):4243.Google Scholar
Wannemacher, R.W., Creasia, D.A., Hines, H.B., Thompson, W.L., and Dinterman, R.E. (1990). “Toxicity, Stability, and Inactivation of Ricin.” Toxicologist 10:166.Google Scholar
Waters, T. (1992). “The Fine Art of Making Poison.” Discover 13(8):2933.Google Scholar
Wheelis, M.L. (1992). “Strengthening Biological Weapons Control Through Global Epidemiological Surveillance.” Politics and the Life Sciences 11:179–89.Google Scholar
Wiley, R.G. and Oeltmann, T.N. (1991). “Ricin and Related Plant Toxins: Mechanism of Action and Neurobiological Applications.” In Keeler, R.F. and Tu, A.T. (eds.), Handbook of Natural Toxins, Vol. 6: Toxicology of Plant and Fungal Compounds. New York: Marcel Dekker.Google Scholar
Wise, D. (1992). “Was Oswald a Spy, and Other Cold War Mysteries.” New York Times Magazine (December 6):44.Google Scholar
Wiseman, A. (1992). “The Organisation of Production of Genetically-Engineered Proteins in Yeast.” Endeavor 16(4):190–93.Google Scholar
Zelicoff, A.P. (1993). Author interview with Dr. Alan Zelicoff, Sandia National Laboratory.Google Scholar
Zilinskas, R.A. (1990). “Biological Warfare and the Third World.” Politics and the Life Sciences 9:5976.Google Scholar
Zilinskas, R.A. (1992). “Terrorism and Biological Weapons: Inevitable Alliance?” Perspectives in Biology and Medicine 34:4472.Google Scholar