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Reduced spatial learning in mice infected with the nematode, Heligmosomoides polygyrus

Published online by Cambridge University Press:  06 April 2009

M. Kavaliers  and
D. D. Colwell
M. Kavaliers
Affiliation:
Division of Oral Biology, Faculty of Dentistry and Neuroscience Program, University of Western Ontario, London, Ontario, CanadaN6A 5C1
D. D. Colwell
Affiliation:
Agriculture Canada Research Station, Box 3000, Main, Lethbridge, Alberta, CanadaT1J 4B1
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Summary

Parasite modification of host behaviour influences a number of critical responses, but little is known about the effects on host spatial abilities. This study examined the effects of infection with the intestinal trichostrongylid nematode, Heligmosomoides polygyrus, on spatial water maze learning by male laboratory mice, Mus musculus. In this task individual mice had to learn the spatial location of a submerged hidden platform using extramaze visual cues. Determinations of spatial performance were made on day 19 post-infection with mice that had been administered either 50 or 200 infective larvae of H. polygyrus. The infected mice displayed over 1 day of testing (6 blocks of 4 trials) significantly poorer acquisition and retention of the water maze task than either sham-infected or control mice, with mice that had received 200 infective larvae displaying significantly poorer spatial performance than individuals receiving 50 larvae. The decrease in spatial learning occurred in the absence of either any symptoms of illness and malaise, or any evident motor, visual and motivational impairments. It is suggested that in this single host system the parasitic infection-induced decrease in spatial learning arises as a side-effect of the host's immunological and neuromodulatory responses and represents a fitness cost of response to infection.

Keywords

spatial learningmemoryspatial abilitiesspatial navigationHeligmosomoides polygyrusbehaviour
Type
Research Article
Information
Parasitology , Volume 110 , Issue 5 , June 1995 , pp. 591 - 597
Copyright
Copyright © Cambridge University Press 1995

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