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Sex Differences in Cognitive Changes in De Novo Parkinson’s Disease

Published online by Cambridge University Press:  11 December 2019

Ece Bayram Open the ORCID record for Ece Bayram [Opens in a new window] ,
Sarah J. Banks ,
Guogen Shan ,
Nikki Kaplan  and
Jessica Z.K. Caldwell
Ece Bayram*
Affiliation:
Department of Neurosciences, University of California San Diego, La Jolla, CA, USA
Sarah J. Banks
Affiliation:
Department of Neurosciences, University of California San Diego, La Jolla, CA, USA
Guogen Shan
Affiliation:
Department of Environmental and Occupational Health, University of Nevada Las Vegas, Las Vegas, NV, USA
Nikki Kaplan
Affiliation:
Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV, USA
Jessica Z.K. Caldwell
Affiliation:
Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV, USA
*
*Correspondence and reprint requests to: Ece Bayram, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093-0886, USA. E-mail: [email protected]
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Abstract

Objective:

To evaluate the sex differences in cognitive course over 4 years in Parkinson’s disease (PD) patients with and without mild cognitive impairment (MCI) compared to controls.

Methods:

Four-year longitudinal cognitive scores of 257 cognitively intact PD, 167 PD-MCI, and 140 controls from the Parkinson’s Progression Markers Initiative were included. Longitudinal scores of men and women, and PD with and without MCI were compared.

Results:

Women had better verbal memory, men had better visuospatial function. There was no interaction between sex, diagnostic group, and/or time (4-year follow-up period).

Conclusions:

Sex differences in cognitive course in de novo PD are similar to healthy aging. Cognitive decline rates in PD with and without MCI are similar for the first 4 years of PD.

Keywords

Parkinson’s diseaseCognitionSexLongitudinal studiesMemoryDecline
Type
Brief Communication
Information
Journal of the International Neuropsychological Society , Volume 26 , Issue 2 , February 2020 , pp. 241 - 249
Copyright
Copyright © INS. Published by Cambridge University Press, 2019 

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