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Reduced Fusiform Gyrus Activation During Face Processing in Pediatric Brain Tumor Survivors

Published online by Cambridge University Press:  04 October 2021

Matthew C. Hocking Open the ORCID record for Matthew C. Hocking [Opens in a new window] ,
Robert T. Schultz ,
Jane E. Minturn ,
Cole Brodsky ,
May Albee  and
John D. Herrington
Matthew C. Hocking*
Affiliation:
Children’s Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA19104, USA Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA19104, USA
Robert T. Schultz
Affiliation:
Children’s Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA19104, USA Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA19104, USA
Jane E. Minturn
Affiliation:
Children’s Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA19104, USA Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA19104, USA
Cole Brodsky
Affiliation:
Children’s Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA19104, USA
May Albee
Affiliation:
Children’s Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA19104, USA
John D. Herrington
Affiliation:
Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA19104, USA
*
*Correspondence and reprint requests to: Matthew C. Hocking, Ph.D., Division of Oncology, The Children’s Hospital of Philadelphia, 3615 Civic Center Blvd., 1427B Abramson Pediatric Research Center, Philadelphia, PA19104, USA. E-mail: [email protected].
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Abstract

Objective:

The neural mechanisms contributing to the social problems of pediatric brain tumor survivors (PBTS) are unknown. Face processing is important to social communication, social behavior, and peer acceptance. Research with other populations with social difficulties, namely autism spectrum disorder, suggests atypical brain activation in areas important for face processing. This case-controlled functional magnetic resonance imaging (fMRI) study compared brain activation during face processing in PBTS and typically developing (TD) youth.

Methods:

Participants included 36 age-, gender-, and IQ-matched youth (N = 18 per group). PBTS were at least 5 years from diagnosis and 2 years from the completion of tumor therapy. fMRI data were acquired during a face identity task and a control condition. Groups were compared on activation magnitude within the fusiform gyrus for the faces condition compared to the control condition. Correlational analyses evaluated associations between neuroimaging metrics and indices of social behavior for PBTS participants.

Results:

Both groups demonstrated face-specific activation within the social brain for the faces condition compared to the control condition. PBTS showed significantly decreased activation for faces in the medial portions of the fusiform gyrus bilaterally compared to TD youth, ps ≤ .004. Higher peak activity in the left fusiform gyrus was associated with better socialization (r = .53, p < .05).

Conclusions:

This study offers initial evidence of atypical activation in a key face processing area in PBTS. Such atypical activation may underlie some of the social difficulties of PBTS. Social cognitive neuroscience methodologies may elucidate the neurobiological bases for PBTS social behavior.

Keywords

Pediatric brain tumorfMRIFace processingFusiform gyrus
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 28 , Issue 9 , October 2022 , pp. 937 - 946
Copyright
Copyright © INS. Published by Cambridge University Press, 2021

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