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Profiles of functional deficits in mild cognitive impairment and dementia: benefits from objective measurement

Published online by Cambridge University Press:  22 February 2010

FERNANDA SPEGGIORIN PEREIRA ,
MÔNICA SANCHES YASSUDA ,
ALEXANDRA MARTINI OLIVEIRA ,
BRENO SATLER DINIZ ,
MÁRCIA RADANOVIC ,
LEDA LEME TALIB ,
WAGNER FARID GATTAZ  and
ORESTES VICENTE FORLENZA
FERNANDA SPEGGIORIN PEREIRA
Affiliation:
Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil
MÔNICA SANCHES YASSUDA
Affiliation:
Department of Gerontology, School of Arts, Sciences and Humanities (EACH). University of São Paulo, São Paulo, São Paulo, Brazil
ALEXANDRA MARTINI OLIVEIRA
Affiliation:
Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil
BRENO SATLER DINIZ
Affiliation:
Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil
MÁRCIA RADANOVIC
Affiliation:
Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil
LEDA LEME TALIB
Affiliation:
Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil
WAGNER FARID GATTAZ
Affiliation:
Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil
ORESTES VICENTE FORLENZA*
Affiliation:
Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil
*
*Correspondence and reprint requests to: Orestes V. Forlenza, Laboratory of Neuroscience (LIM 27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Rua Dr. Ovídio Pires de Campos 785, 3rd floor, 05403-010 São Paulo, S.P., Brazil. E-mail: [email protected]
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Abstract

The magnitude of functional impairment that may indicate the threshold between MCI and incipient Alzheimer’s disease (AD) has not been clearly defined. The objective was to examine the pattern of functional impairment in the continuum MCI-AD. Eighty-nine older adults (32 cognitively unimpaired, 31 MCI, and 26 AD patients) were examined with the Brazilian version of the Direct Assessment of Functional Status (DAFS-BR) at a university-based memory clinic. MCI patients were sub-divided according to the progression to AD upon follow-up, and had baseline cognitive, functional and biological variables analyzed. MCI patients displayed mild deficits in functional abilities, with intermediate scores as compared to controls and AD. The DAFS-BR items that differentiated MCI from controls involved the ability to deal with finances and shopping skills. At baseline, scores obtained by MCI patients who converted to AD were not significantly different from scores of nonconverters. The magnitude of functional deficits was associated with AD-like pathological findings in the CSF. In conclusion, MCI patients present with early functional changes in complex, instrumental abilities that require the integrity of memory and executive functions. The objective measurement of the functional state may help identify older adults with increased risk of developing dementia in the MCI-AD continuum. (JINS, 2010, 16, 297–305.)

Keywords

NeuropsychologyActivities of daily livingMild cognitive impairmentAlzheimer’s diseaseDementiaCSF biomarkers
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 16 , Issue 2 , March 2010 , pp. 297 - 305
Copyright
Copyright © The International Neuropsychological Society 2010

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