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Longitudinal Volumetric Changes following Traumatic Brain Injury: A Tensor-Based Morphometry Study

Published online by Cambridge University Press:  13 August 2012

Kimberly D.M. Farbota ,
Aparna Sodhi ,
Barbara B. Bendlin ,
Donald G. McLaren ,
Guofan Xu ,
Howard A. Rowley  and
Sterling C. Johnson
Kimberly D.M. Farbota*
Affiliation:
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin
Aparna Sodhi
Affiliation:
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
Barbara B. Bendlin
Affiliation:
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
Donald G. McLaren
Affiliation:
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin
Guofan Xu
Affiliation:
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
Howard A. Rowley
Affiliation:
Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
Sterling C. Johnson
Affiliation:
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
*
Correspondence and reprint requests to: Kimberly D.M. Farbota, Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, J5M/162 CSC, 600 Highland Avenue, Madison, Wisconsin, 53792. E-mail: [email protected]
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Abstract

After traumatic injury, the brain undergoes a prolonged period of degenerative change that is paradoxically accompanied by cognitive recovery. The spatiotemporal pattern of atrophy and the specific relationships of atrophy to cognitive changes are ill understood. The present study used tensor-based morphometry and neuropsychological testing to examine brain volume loss in 17 traumatic brain injury (TBI) patients and 13 controls over a 4-year period. Patients were scanned at 2 months, 1 year, and 4 years post-injury. High-dimensional warping procedures were used to create change maps of each subject's brain for each of the two intervals. TBI patients experienced volume loss in both cortical areas and white matter regions during the first interval. We also observed continuing volume loss in extensive regions of white matter during the second interval. Neuropsychological correlations indicated that cognitive tasks were associated with subsequent volume loss in task-relevant regions. The extensive volume loss in brain white matter observed well beyond the first year post-injury suggests that the injured brain remains malleable for an extended period, and the neuropsychological relationships suggest that this volume loss may be associated with subtle cognitive improvements. (JINS, 2012, 18, 1–13)

Keywords

Longitudinal studiesRecovery of functionBrain injurieshumansNeurosciencesMagnetic resonance imagingChronic brain injuriesBrain mappingApoptosisNecrosis
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 18 , Issue 6 , November 2012 , pp. 1006 - 1018
Copyright
Copyright © The International Neuropsychological Society 2012

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