Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-26T15:50:17.810Z Has data issue: false hasContentIssue false
  • English
  • Français

Learning, retrieval, and recognition are compromised in aMCI and mild AD: Are distinct episodic memory processes mediated by the same anatomical structures?

Published online by Cambridge University Press:  19 October 2009

MARCIO L. F. BALTHAZAR ,
CLARISSA L. YASUDA ,
FERNANDO CENDES  and
BENITO P. DAMASCENO
MARCIO L. F. BALTHAZAR
Affiliation:
Neuropsychology and Neurolinguistics Unit, Department of Neurology, Medical Sciences School, University of Campinas (UNICAMP), Campinas/SP, Brazil Laboratory of Neuroimaging, Department of Neurology, Medical Sciences School, University of Campinas (UNICAMP), Campinas/SP, Brazil
CLARISSA L. YASUDA
Affiliation:
Laboratory of Neuroimaging, Department of Neurology, Medical Sciences School, University of Campinas (UNICAMP), Campinas/SP, Brazil
FERNANDO CENDES
Affiliation:
Laboratory of Neuroimaging, Department of Neurology, Medical Sciences School, University of Campinas (UNICAMP), Campinas/SP, Brazil
BENITO P. DAMASCENO*
Affiliation:
Neuropsychology and Neurolinguistics Unit, Department of Neurology, Medical Sciences School, University of Campinas (UNICAMP), Campinas/SP, Brazil
*
*Correspondence and reprint requests to: Prof. Dr. Benito P. Damasceno, Department of Neurology, Medical School, University of Campinas (UNICAMP), Box 6111, Postcode: 13083-970, Campinas-SP, Brazil. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Performance of different episodic memory processes in patients with amnestic mild cognitive impairment (aMCI) and mild Alzheimer’s disease (AD) and their anatomical correlates are not completely understood. We evaluated the performance of 48 subjects (17 with aMCI, 15 with mild AD, and 16 controls) on the Rey Auditory Verbal Learning Test (RAVLT). A brain MRI voxel-based morphometry (VBM) analysis was run with the aim of evaluating the correlations between RAVLT and gray matter density. All memory processes were compromised in aMCI and mild AD. Also, the same cerebral structures were involved in all RAVLT stages. Learning and delayed recall were more related to the medial prefrontal cortex and hippocampi, whereas recognition was more related to the thalamic nuclei and caudate nucleus, particularly in the left side. Our findings suggest that these structures may act as a complex functional system and are involved in the acquisition of new information. (JINS, 2010, 16, 205–209.)

Keywords

Episodic memoryRAVLTVoxel-based morphometryCognitive disordersNeurodegenerative diseasesMagnetic resonance imaging
Type
Brief Communications
Information
Journal of the International Neuropsychological Society , Volume 16 , Issue 1 , January 2010 , pp. 205 - 209
Copyright
Copyright © The International Neuropsychological Society 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Alexopoulos, G.S., Abrams, R.C., Young, R.C., & Shamoian, C.A. (1988). Cornell Scale for Depression in Dementia. Biological Psychiatry, 23, 271–284.CrossRefGoogle ScholarPubMed
Brucki, S.M., Nitrini, R., Caramelli, P., Bertolucci, P.H., & Okamoto, I.H. (2003). Suggestions for utilization of the Mini-Mental State Examination in Brazil. Arquivos de Neuropsiquiatria, 61, 777–781.CrossRefGoogle ScholarPubMed
Christensen, A.-L. (1979). Luria’s Neuropsychological Investigation (2nd ed.). Copenhagen: Munksgaard.Google Scholar
Colliot, O., Chetelat, G., Chupin, M., Desgranges, B., Magnin, B., Benali, H., et al. (2008). Discrimination between Alzheimer disease, mild cognitive impairment, and normal aging by using automated segmentation of the hippocampus. Radiology, 248, 194–201.CrossRefGoogle ScholarPubMed
Corbetta, M., Miezin, F.M., Dobmeyer, S., Shulman, G.L., & Petersen, S.E. (1991). Selective and divided attention during visual discriminations of shape, color, and speed: Functional anatomy by positron emission tomography. Journal of Neuroscience, 11, 2383–2402.CrossRefGoogle ScholarPubMed
Eichenbaum, H., & Fortin, N.J. (2005). Bridging the gap between brain and behavior: Cognitive and neural mechanisms of episodic memory. Journal of the Experimental Analysis of Behavior, 84, 619–629.CrossRefGoogle Scholar
Good, C.D., Johnsrude, I.S., Ashburner, J., Henson, R.N., Friston, K.J., & Frackowiak, R.S. (2001). A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage, 14, 21–36.CrossRefGoogle ScholarPubMed
Grahn, J.A., Parkinson, J.A., & Owen, A.M. (2009). The role of the basal ganglia in learning and memory: Neuropsychological studies. Behavioural Brain Research, 199, 53–60.CrossRefGoogle ScholarPubMed
Kaplan, E.F., Goodglass, H., & Weintraub, S. (1983). The Boston Naming Test (2nd ed.). Philadelphia: Lea & Febiger.Google Scholar
Knight, R.T. (1984). Decreased response to novel stimuli after prefrontal lesions in man. Electroencephalography and Clinical Neurophysiology, 59, 9–20.CrossRefGoogle ScholarPubMed
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E.M. (1984). Clinical diagnosis of Alzheimer’s disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology, 34, 939–944.CrossRefGoogle ScholarPubMed
Morris, J. (1993). The clinical dementia rating (CDR): Current version and scoring rules. Neurology, 43, 2412–2414.CrossRefGoogle ScholarPubMed
Petrides, M. (2002). The mid-ventrolateral prefrontal cortex and active mnemonic retrieval. Neurobiology of Learning and Memory, 78, 528–538.CrossRefGoogle ScholarPubMed
Rey, A. (1964). L’examen clinique in psychologie. Paris: Press Universitaire de France.Google Scholar
Squire, L.R., Stark, C.E., & Clark, R.E. (2004). The medial temporal lobe. Annual Review of Neuroscience, 27, 279–306.CrossRefGoogle ScholarPubMed
Tricomi, E., & Fiez, J.A. (2008). Feedback signals in the caudate reflect goal achievement on a declarative memory task. Neuroimage, 41, 1154–1167.CrossRefGoogle ScholarPubMed
Tulving, E. (2002). Episodic memory: From mind to brain. Annual Review of Psychology, 53, 1–25.CrossRefGoogle Scholar
Van der Werf, Y.D., Jolles, J., Witter, M.P., & Uylings, H.B. (2003). Contributions of thalamic nuclei to declarative memory functioning. Cortex, 39, 1047–1062.CrossRefGoogle ScholarPubMed
Wechsler, D. (1987). Wechsler Memory Scale – Revised: New York: The Psychological Corporation.Google Scholar
Winblad, B., Palmer, K., Kivipelto, M., Jelic, V., Fratiglioni, I. Wahlund, L.O., et al. (2004). Mild cognitive impairment – beyond controversies, towards a consensus: Report of the International Working Group on Mild Cognitive Impairment. Journal of Internal Medicine, 256, 240–246.CrossRefGoogle Scholar