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Functional and anatomical memory indices in patients with or at risk for Alzheimer's disease

Published online by Cambridge University Press:  01 March 2004

NATALIE A. PHILLIPS ,
HOWARD CHERTKOW ,
MANON M. LEBLANC ,
HEATHER PIM  and
SUSAN MURTHA
NATALIE A. PHILLIPS
Affiliation:
Centre for Research in Human Development/Department of Psychology, Concordia University, Montreal, Quebec, Canada Lady Davis Institute for Medical Research and Department of Clinical Neurosciences, Sir Mortimer B. Davis–Jewish General Hospital, Montreal, Quebec, Canada
HOWARD CHERTKOW
Affiliation:
Lady Davis Institute for Medical Research and Department of Clinical Neurosciences, Sir Mortimer B. Davis–Jewish General Hospital, Montreal, Quebec, Canada Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
MANON M. LEBLANC
Affiliation:
Queen's School of Business, Queens University, Kingston, Ontario, Canada
HEATHER PIM
Affiliation:
Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
SUSAN MURTHA
Affiliation:
Department of Psychology, York University, Toronto, Ontario, Canada
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Abstract

We investigated the sensitivity of the P300 event-related brain potential (ERP) recorded during a memory-demanding task to memory function in subjects with dementia of the Alzheimer's type (DAT), those with mild cognitive impairment (MCI), and normal elderly controls. We also explored the ability of neuropsychological (delayed verbal memory), neuroanatomical (MRI-based hippocampal volume), and electrophysiological (memory search P300 amplitude) memory measures to distinguish between the three subject groups using discriminant function analyses. Fourteen patients with DAT, 16 with MCI, and 15 age- and education-matched controls were tested. P300 amplitude was reduced in DAT subjects at all levels of memory load; however, it did not differ between MCI and control subjects. Delayed verbal memory performance best discriminated DAT from MCI and control subjects, while delayed verbal memory and hippocampal volume best discriminated MCI subjects from controls. These results support the utility of neuropsychological and neuroanatomical measures in diagnosing dementia and do not support the notion that P300 amplitude is sensitive to mild memory dysfunction when measured using the current task. (JINS, 2004, 10, 200–210.)

Keywords

MemoryDementiaEvent-related brain potentialsHippocampal volume
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 10 , Issue 2 , March 2004 , pp. 200 - 210
Copyright
© 2004 The International Neuropsychological Society

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