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Entorhinal cortex volume in older adults: Reliability and validity considerations for three published measurement protocols

Published online by Cambridge University Press:  09 August 2010

C.C. PRICE ,
M.F. WOOD ,
C.M. LEONARD ,
S. TOWLER ,
J. WARD ,
H. MONTIJO ,
I. KELLISON ,
D. BOWERS ,
T. MONK  and
J.C. NEWCOMER
...Show all authors
C.C. PRICE*
Affiliation:
Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida McKnight Brain Institute, University of Florida, Gainesville, Florida Department of Anesthesiology, College of Medicine, University of Florida, Gainesville, Florida
M.F. WOOD
Affiliation:
College of Medicine, University of Florida, Gainesville, Florida
C.M. LEONARD
Affiliation:
McKnight Brain Institute, University of Florida, Gainesville, Florida Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida
S. TOWLER
Affiliation:
Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida
J. WARD
Affiliation:
Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida
H. MONTIJO
Affiliation:
Duke University School of Medicine, Durham, North Carolina
I. KELLISON
Affiliation:
Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida
D. BOWERS
Affiliation:
Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida McKnight Brain Institute, University of Florida, Gainesville, Florida
T. MONK
Affiliation:
Department of Anesthesiology, Duke University, Durham, North Carolina
J.C. NEWCOMER
Affiliation:
Department of Psychiatry, Washington University, St. Louis, Missouri
I. SCHMALFUSS
Affiliation:
Department of Radiology, College of Medicine, University of Florida, Gainesville, Florida Department of Radiology, North Florida South Georgia Veteran Administration, Gainesville, Florida
*
*Correspondence and reprint requests to: Catherine C. Price, Ph.D., Clinical and Health Psychology, 101 S. Newell Drive, PO Box 100165, University of Florida, Gainesville, FL 32610. E-mail: [email protected]
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Abstract

Measuring the entorhinal cortex (ERC) is challenging due to lateral border discrimination from the perirhinal cortex. From a sample of 39 nondemented older adults who completed volumetric image scans and verbal memory indices, we examined reliability and validity concerns for three ERC protocols with different lateral boundary guidelines (i.e., Goncharova, Dickerson, Stoub, & deToledo-Morrell, 2001; Honeycutt et al., 1998; Insausti et al., 1998). We used three novice raters to assess inter-rater reliability on a subset of scans (216 total ERCs), with the entire dataset measured by one rater with strong intra-rater reliability on each technique (234 total ERCs). We found moderate to strong inter-rater reliability for two techniques with consistent ERC lateral boundary endpoints (Goncharova, Honeycutt), with negligible to moderate reliability for the technique requiring consideration of collateral sulcal depth (Insausti). Left ERC and story memory associations were moderate and positive for two techniques designed to exclude the perirhinal cortex (Insausti, Goncharova), with the Insausti technique continuing to explain 10% of memory score variance after additionally controlling for depression symptom severity. Right ERC-story memory associations were nonexistent after excluding an outlier. Researchers are encouraged to consider challenges of rater training for ERC techniques and how lateral boundary endpoints may impact structure-function associations. (JINS, 2010, 16, 846–855.)

Keywords

InsaustiGoncharovaMemoryParagraph memoryStory memoryAlzheimer
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 16 , Issue 5 , September 2010 , pp. 846 - 855
Copyright
Copyright © The International Neuropsychological Society 2010

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