Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-26T16:34:12.104Z Has data issue: false hasContentIssue false
  • English
  • Français

Differential disruptions of working memory components in schizophrenia in an object–location binding task using the suppression paradigm

Published online by Cambridge University Press:  27 June 2006

PIERRE SALAMÉ ,
FRANCK BURGLEN  and
JEAN-MARIE DANION
PIERRE SALAMÉ
Affiliation:
INSERM, Département de Psychiatrie, Hôpitaux Universitaires, Strasbourg Cedex, France
FRANCK BURGLEN
Affiliation:
INSERM, Département de Psychiatrie, Hôpitaux Universitaires, Strasbourg Cedex, France
JEAN-MARIE DANION
Affiliation:
INSERM, Département de Psychiatrie, Hôpitaux Universitaires, Strasbourg Cedex, France
Get access Rights & Permissions [Opens in a new window]

Abstract

Patients with schizophrenia exhibit normal memory for separate objects or locations but are disproportionately impaired when the items must be bound for later recognition in a working memory (WM) setting (Burglen et al., 2004). This study aimed at further evaluating the contribution of each WM component to the patients' binding deficit, using selective articulatory, visuospatial, and executive suppression tasks. In the object–location binding task used, a trial comprised the successive presentation of three drawings of familiar objects and of three spatial locations in a grid, either separately (i.e., objects alone or locations alone) or bound (i.e., object+location), and required a recognition test following an 8-s delay. In the suppression modalities, suppression was continuous from presentation to test. A total of 22 patients with schizophrenia and 24 healthy controls participated. The results confirmed the binding deficit in patients' performance in the baseline modality where no suppression was required. They also showed that patients were particularly disrupted when suppression was visuospatial. This last finding extends the specific visuospatial vulnerability in schizophrenia to the operations of binding. (JINS, 2006, 12, 510–518.)Note: The data provided in this study have been partly matter of a university thesis presented by Franck Burglen.

Keywords

On-line processingArticulatoryVisuospatialExecutiveInterferenceEpisode
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 12 , Issue 4 , July 2006 , pp. 510 - 518
Copyright
© 2006 The International Neuropsychological Society

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Aleman, A., Hijman, R., Dehaan, E.H.F., & Kahn, R.S. (1999). Memory impairment in schizophrenia: A meta-analysis. American Journal of Psychiatry, 156, 1358–1366.Google Scholar
American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (pp. 273–290). Washington, DC: American Psychiatric Association Press.
Andreasen, N.C., Paradiso, S., & Oleary, D.S. (1998). “Cognitive dysmetria” as an integrative theory of schizophrenia: A dysfunction in cortical subcortical-cerebellar circuitry? Schizophrenia Bulletin, 24, 203–218.Google Scholar
Baddeley, A.D. (1986). Working memory. Oxford: Oxford University Press.
Baddeley, A.D. & Hitch, G.J. (1974). Working memory. In G. Bower (Ed.), The psychology of learning and motivation: Advances in research and theory. Vol. VIII (pp. 47–90). New York: Academic Press.
Beech, A., Powell, T., McWilliam, J., & Claridge, G. (1989). Evidence of reduced ‘cognitive inhibition’ in schizophrenia. British Journal of Clinical Psychology, 28, 109–116.Google Scholar
Brebion, G., Amador, X.F., Smith, M.J., & Gorman, J.M. (1998). Memory impairment and schizophrenia: The role of processing speed. Schizophrenia Research, 30, 31–39.Google Scholar
Brebion, G., Smith, M.J., Gorman, J.M., & Amador, X.F. (1996). Reality monitoring failure in schizophrenia: The role of selective attention. Schizophrenia Research, 22, 173–180.Google Scholar
Burglen, F., Marczewski, P., Mitchell, K.J., Van der Linden, M., Johnson, M.K., Danion, J.-M., & Salamé, P. (2004). Impaired performance in a working memory binding task in patients with schizophrenia. Psychiatry Research, 125, 247–255.Google Scholar
Clare, L., McKenna, P.J., Mortimer, A.M., & Baddeley, A.D. (1993). Memory in schizophrenia: What is impaired and what is preserved? Neuropsychologia, 31, 1225–1241.Google Scholar
Elvevag, B., Weinberger, D.R., & Goldberg, T.E. (2002). The phonological similarity effect in short-term memory serial recall in schizophrenia. Psychiatry Research, 112, 77–81.Google Scholar
Fleming, K., Goldberg, T.E., Binks, S., Randolph, C., Gold, J.M., & Weinberger, D.R. (1997). Visuospatial working memory in patients with schizophrenia. Biological Psychiatry, 41, 43–49.Google Scholar
Fraser, D., Park, S., Clark, G., Yohanna, D., & Houk, J.C. (2004). Spatial serial order processing in schizophrenia. Schizophrenia Research, 70, 203–213.Google Scholar
Glahn, D.C., Therman, S., Manninen, M., Huttunen, M., Kaprio, J., Lonnqvist, J., & Cannon, T.D. (2003). Spatial working memory as an endophenotype for schizophrenia. Biological Psychiatry, 53, 624–626.Google Scholar
Gold, J.M., Wilk, C.M., McMahon, R.P., Buchanan, R.W., & Luck, S.J. (2003). Working memory for visual features and conjunctions in schizophrenia. Journal of Abnormal Psychology, 112, 61–71.Google Scholar
Heinrichs, R.W. & Zakzanis, K.K. (1998). Neurocognitive deficit in schizophrenia: A quantitative review of the evidence. Neuropsychology, 12, 426–445.Google Scholar
Keefe, R.S.E. (2000). Working memory dysfunction and its relevance to schizophrenia. In T. Sharma & P.D. Harvey (Eds.), Cognition in schizophrenia (pp. 16–50). Oxford: Oxford University Press.
Kolb, B. & Whishaw, I.Q. (1983). Performance of schizophrenic patients on tests sensitive to left of right frontal, temporal, or parietal function in neurological patients. Journal of Nervous and Mental Disease, 171, 435–443.Google Scholar
Leiderman, E.A. & Strejilevich, S.A. (2004). Visuospatial deficits in schizophrenia: Central executive and memory subsystems impairments. Schizophrenia Research, 68, 217–223.Google Scholar
Lezak, M.D. (1995). Neuropsychological assessment. (3rd ed.). Oxford: Oxford University Press.
Logie, R.H., Zucco, G.M., & Baddeley, A.D. (1990). Interference with visual short-term memory. Acta Psychologica, 75, 55–74.Google Scholar
Luck, S.J. & Vogel, E.K. (1997). The capacity of visual working memory for features and conjunctions. Nature, 390, 279–281.Google Scholar
Macmillan, N.A. & Creelman, C.D. (1991). Detection theory: A user's guide. Cambridge: Cambridge University Press.
McKenna, P.J., Tamlyn, D., Lund, C.E., Mortimer, A.M., Hammond, S., & Baddeley, A.D. (1990). Amnesic syndrome in schizophrenia. Psychological Medicine, 20, 967–972.Google Scholar
Mitchell, K.J., Johnson, M.K., Raye, C.L., Mather, M., & D'Esposito, M. (2000). Aging and reflective processes of working memory: Binding and test load deficits. Psychology and Aging, 15, 527–541.Google Scholar
Murray, D.J. (1968). Articulation and acoustic confusability in short-term memory. Journal of Experimental Psychology, 78, 679–684.Google Scholar
Nathanieljames, D.A., Brown, R., & Ron, M.A. (1996). Memory impairment in schizophrenia: Its relationship to executive function. Schizophrenia Research, 21, 85–96.Google Scholar
O'Donnell, B.F., Swearer, J.M., Smith, L.T., Nestor, P.G., Shenton, M.E., & Mccarley, R.W. (1996). Selective deficits in visual perception and recognition in schizophrenia. American Journal of Psychiatry, 153, 687–692.Google Scholar
Park, S. & Holzman, P.S. (1992). Schizophrenics show spatial working memory deficits. Archives of General Psychiatry, 49, 975–982.Google Scholar
Pelletier, M., Achim, A.M., Montoya, A., Lal, S., & Lepage, M. (2005). Cognitive and clinical moderators of recognition memory in schizophrenia: A meta-analysis. Schizophrenia Research, 74, 233–252.Google Scholar
Rabinowicz, E.F., Opler, L.A., Owen, D.R., & Knight, R.A. (1996). Dot enumeration perceptual organization task (DEPOT): Evidence for a short-term visual memory deficit in schizophrenia. Journal of Abnormal Psychology, 105, 336–348.Google Scholar
Salamé, P., Danion, J.-M., Peretti, C.S., & Cuervo, C. (1998). The state of functioning of working memory in schizophrenia. Schizophrenia Research, 30, 11–29.Google Scholar
Snodgrass, J.G. & Vanderwart, M. (1980). A standardized set of 260 pictures: Norms for name agreement, image agreement, familiarity, and visual complexity. Journal of Experimental Psychology—Human Learning, 6, 174–215.Google Scholar
Schatz, J. (1998). Cognitive processing efficiency in schizophrenia: Generalized vs. domain specific deficits. Schizophrenia Research, 30, 41–49.Google Scholar
Tamlyn, D., McKenna, P.J., Mortimer, A.M., Lund, C.E., Hammond, S., & Baddeley, A.D. (1992). Memory impairment in schizophrenia: Its extent, affiliations and neuropsychological character. Psychological Medicine, 22, 101–115.Google Scholar
Wechsler, D. (1981). Manual for the Wechsler Adult Intelligence Scale. New York: Psychological Corporation.
Wheeler, M.E. & Treisman, A.M. (2002). Binding in short-term visual memory. Journal of Experimental Psychology—General, 131, 48–64.Google Scholar
Waters, F.A.V., Badcock, J.C., Maybery, M.T., & Michie, P.T. (2003). Inhibition in schizophrenia: Association with auditory hallucinations. Schizophrenia Research, 62, 275–280.Google Scholar
Waters, F.A.V., Maybery, M.T., Badcock, J.C., & Michie, P.T. (2004). Context memory and binding in schizophrenia. Schizophrenia Research, 68, 119–125.Google Scholar
Woods, S.W. (2003). Chlorpromazine equivalent doses for the newer atypical antipsychotics. Journal of Clinical Psychiatry, 64, 663–667.Google Scholar