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Cognitive decline in Parkinson’s disease: A prospective longitudinal study

Published online by Cambridge University Press:  01 May 2009

DINO MUSLIMOVIĆ ,
BART POST ,
JOHANNES D. SPEELMAN ,
ROB J. DE HAAN  and
BEN SCHMAND
DINO MUSLIMOVIĆ*
Affiliation:
Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
BART POST
Affiliation:
Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
JOHANNES D. SPEELMAN
Affiliation:
Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
ROB J. DE HAAN
Affiliation:
Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
BEN SCHMAND
Affiliation:
Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands Department of Psychonomics, University of Amsterdam, Amsterdam, The Netherlands
*
*Correspondence and reprint requests to: Dino Muslimović, Department of Neurology, Academic Medical Centre, University of Amsterdam, H2-222, PO Box 22660, 1100 DD Amsterdam, The Netherlands. E-mail: [email protected]
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Abstract

This controlled prospective study examined the evolution and predictors of cognitive decline in Parkinson’s disease (PD). Consecutive patients diagnosed at baseline with PD (n = 89), established PD (EPD) patients (n = 52) with a mean disease duration of 6.5 years, and healthy control subjects (n = 64) underwent extensive neuropsychological assessment twice, approximately 3 years apart. A standardized regression-based method, normative data, and multivariate normative comparisons were used to assess the cognitive course of PD. Cognitive performance of newly diagnosed patients decreased significantly over time, particularly on measures of psychomotor speed and attention and to a lesser extent on tests of memory, visuospatial skills, and executive functions. About 50% of the patients showed cognitive decline and 9% developed dementia. Similar results were observed in EPD patients. None of the baseline features predicted cognitive change in newly diagnosed patients, whereas age at disease onset and axial impairment (postural and gait disorders) contributed to decline in established patients. We conclude that within few years after diagnosis, PD patients show faster rate of cognitive decline than matched healthy subjects, particularly in domains of attention and psychomotor speed. Selection bias probably led to underestimation of the true extent of cognitive decline in established patients. (JINS, 2009, 15, 426–437.)

Keywords

Parkinson’s diseaseCognitive impairmentNatural historyNeuropsychological testsLongitudinal designPrognostic factors
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 15 , Issue 3 , May 2009 , pp. 426 - 437
Copyright
Copyright © The International Neuropsychological Society 2009

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References

REFERENCES

Aarsland, D., Andersen, K., Larsen, J.P., Lolk, A., & Kragh-Sørensen, P. (2003). Prevalence and characteristics of dementia in Parkinson disease: An 8-year prospective study. Archives of Neurology, 60, 387–392.Google Scholar
Aarsland, D., Andersen, K., Larsen, J.P., Perry, R., Wentzel-Larsen, T., Lolk, A., & Kragh-Sørensen, P. (2004). The rate of cognitive decline in Parkinson disease. Archives of Neurology, 61, 1906–1911.CrossRefGoogle ScholarPubMed
Benton, A.L. & Hamsher, K.D.S. (1976). Multilingual Aphasia Examination. Iowa City, IA: University of Iowa.Google Scholar
Benton, A.L., Hamsher, K., Varney, N., & Spreen, O. (1983). Contributions to neuropsychological assessment—A clinical manual. New York: Oxford University Press.Google Scholar
Burn, D.J., Rowan, E.N., Allan, L.M., Molloy, S., O’Brien, J.T., & McKeith, I.G. (2006). Motor subtype and cognitive decline in Parkinson’s disease, Parkinson’s disease with dementia, and dementia with Lewy bodies. Journal of Neurology, Neurosurgery, and Psychiatry, 77, 585–589.CrossRefGoogle ScholarPubMed
Caparros-Lefebvre, D., Pecheux, N., Petit, V., Duhamel, A., & Petit, H. (1995). Which factors predict cognitive decline in Parkinson’s disease? Journal of Neurology, Neurosurgery, and Psychiatry, 58, 51–55.CrossRefGoogle ScholarPubMed
Culbertson, W.C. & Zilmer, E. (2001). The Tower of LondonDx (TOLDx): Manual. North Tonawanda, NY: Multi-Health Systems.Google Scholar
Emre, M., Aarsland, D., Brown, R., Burn, D.J., Duyckaerts, C., Mizuno, Y., Broe, A.G., Cummings, J., Dickson, D.W., Gauthier, S., Goldman, J., Goetz, C., Korczyn, A., Lees, A., Levy, R., Litvan, I., McKeith, I., Olanow, W., Poewe, W., Quinn, N., Sampaio, C., Tolosa, E., & Dubois, B. (2007). Clinical diagnostic criteria for dementia associated with Parkinson’s disease. Movement Disorders, 22, 1689–1707.Google Scholar
Esselink, R.A., de Bie, R.M., de Haan, R.J., Lenders, M.W., Nijssen, P.C., Staal, M.J., Smeding, H.M., Schuurman, P.R., Bosch, D.A., & Speelman, J.D. (2004). Unilateral pallidotomy versus bilateral subthalamic nucleus stimulation in PD: A randomized trial. Neurology, 62, 201–207.CrossRefGoogle ScholarPubMed
Fahn, S., Elton, R.I., & members of the UPDRS Development Committee. (1987). In Fahn, S., Marsden, C.D., Calne, D.B. & Goldstein, M. (Eds.), Recent development in Parkinson’s disease. New York: Macmillan Health Care Information 153–164.Google Scholar
Flynn, J.R. (1987). Massive IQ gains in 14 nations: What IQ tests really measure? Psychological Bulletin, 101, 171–191.Google Scholar
Folstein, M.F., Folstein, S.E., & McHugh, P.R. (1975). “Mini Mental-State”: A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198.CrossRefGoogle ScholarPubMed
Frerichs, R.J. & Tuokko, H.A. (2005). A comparison of methods for measuring cognitive change in older adults. Archives of Clinical Neuropsychology, 20, 321–333.Google Scholar
Gelb, D.J., Oliver, E., & Gilman, S. (1999). Diagnostic criteria for Parkinson disease. Archives of Neurology, 56, 33–39.Google Scholar
Hely, M.A., Read, W.G., Adena, M.A., Halliday, G.M., & Morris, J.G. (2008). The Sydney multicenter study of Parkinson’s disease: The inevitability of dementia at 20 years. Movement Disorders, 23, 837–844.Google Scholar
Hoehn, M.M. & Yahr, M.D. (1967). Parkinsonism: Onset, progression and mortality. Neurology, 17, 427–442.CrossRefGoogle ScholarPubMed
Huizenga, H.M., Smeding, H.M., Grasman, R.P., & Schmand, B. (2007). Multivariate normative comparisons. Neuropsychologia, 45, 2534–2542.CrossRefGoogle ScholarPubMed
Kaplan, E., Goodglass, H., & Weintraub, S. (1983). Boston Naming Test. Philadelphia, PA: Lea & Febiger.Google Scholar
Keith, R.A., Granger, C.V., Hamilton, B.B., & Sherwin, F.S. (1987). The Functional Independence Measure: A new tool for rehabilitation. In Eisenberg, M.G. & Grzesiak, R.G. (Eds.), Advances in clinical rehabilitation. New York: Springer.Google Scholar
Levy, G., Tang, M.X., Louis, E.D., Cote, L.J., Alfaro, B., Mejia, H., Stern, Y., & Marder, K. (2000). Motor impairment in PD: Relationship to incident dementia and age. Neurology, 55, 539–544.Google Scholar
Levy, G., Tang, M.X., Louis, E.D., Cote, L.J., Alfaro, B., Mejia, H., Stern, Y., & Marder, K. (2002). The association of incident dementia with mortality in PD. Neurology, 59, 1708–1713.CrossRefGoogle ScholarPubMed
Lindeboom, J. & Matto, D. (1994). Digit series and Knox cubes as concentration tests for elderly subjects [in Dutch]. Tijdschrift Gerontologie en Geriatrie, 25, 63–66.Google ScholarPubMed
Lindeboom, J., Schmand, B., Tulner, L., Walstra, G., & Jonker, C. (2002). Visual Association Test to detect early dementia of the Alzheimer type. Journal of Neurology, Neurosurgery, and Psychiatry, 73, 126–133.CrossRefGoogle ScholarPubMed
Lineweaver, T.T., Bond, M.W., Thomas, R.G., & Salmon, D.P. (1999). A normative study of Nelson’s (1976) modified version of the Wisconsin Card Sorting Test in healthy older adults. Clinical Neuropsychologist, 13, 328–347.CrossRefGoogle ScholarPubMed
Luteijn, F. & Barelds, D.P.H. (2004). Groningen Intelligence Test 2 (GIT-2): Manual. Amsterdam, The Netherlands: Harcourt Assessment BV.Google Scholar
Mahoney, F.I. & Barthel, D.W. (1965). Functional evaluation: The Barthel Index. State Medical Journal, 14, 61–65.Google Scholar
Marien, P., Mempaey, E., Vervaet, A., Saerens, J., & de Deyn, P.P. (1998). Normative data for the Boston Naming Test in native Dutch-speaking Belgian elderly. Brain Language, 65, 447–467.CrossRefGoogle ScholarPubMed
McSweeney, A.J., Naugle, R.I., Chelune, G.J., & Luders, H. (1993). “T scores for change”: An illustration of a regression approach to depicting change in clinical neuropsychology. Clinical Neuropsychologist, 7, 300–312.CrossRefGoogle Scholar
Muslimovic, D., Post, B., Speelman, J.D., & Schmand, B. (2005). Cognitive profile of patients with newly diagnosed Parkinson disease. Neurology, 65, 1239–1245.Google Scholar
Muslimovic, D., Schmand, B., Speelman, J.D., & de Haan, R.J. (2007). Course of cognitive decline in Parkinson’s disease: A meta-analysis. Journal of the International Neuropsychological Society, 13, 920–932.Google Scholar
Nelson, H.E. (1976). A Modified Card Sorting Test sensitive to frontal lobe defects. Cortex, 12, 313–324.Google Scholar
Owen, A.M., James, M., Leigh, P.N., Summers, B.A., Marsden, C.D., Quinn, N.P., Lange, K.W., & Robbins, T.W. (1992). Fronto-striatal cognitive deficits at different stages of Parkinson’s disease. Brain, 115, 1727–1751.CrossRefGoogle ScholarPubMed
Palazzini, E., Soliveri, P., Filippini, G., Fetoni, V., Zappacosta, B., Scigliano, G., Monza, D., Caraceni, T., & Girotti, F. (1995). Progression of motor and cognitive impairment in Parkinson’s disease. Journal of Neurology, 242, 535–540.CrossRefGoogle ScholarPubMed
Post, B., Merkus, M.P., de Bie, R.M., de Haan, R.J., & Speelman, J.D. (2005). Unified Parkinson’s Rating Scale for motor examination: Are ratings of nurses, residents in neurology, and movement disorder specialists interchangeable? Movement Disorders, 20, 1577–1584.CrossRefGoogle ScholarPubMed
Reid, W.G.J., Hely, M.A., Morris, J.G.L., Broe, G.A., Adena, M., O’Sullivan, D.J., & Williamson, P.M. (1996). A longitudinal study of Parkinson’s disease: Clinical and neuropsychological correlates of dementia. Journal of Clinical Neuroscience, 3, 327–333.Google Scholar
Reitan, R.M. (1992). Trail Making Test: Manual for administration and scoring. Tucson, AZ: Reitan Neuropsychological Laboratory.Google Scholar
Rey, A. (1964). L’examen clinique en psychologie. Paris, France: Presses Universitaires de France.Google Scholar
Rothman, K.J. (1990). No adjustments are needed for multiple comparisons. Epidemiology, 1, 43–46.CrossRefGoogle ScholarPubMed
Royall, D.R., Cordes, D.A., & Polk, M. (1998). CLOX: An executive clock drawing task. Journal of Neurology, Neurosurgery, and Psychiatry, 64, 588–594.Google Scholar
Schmand, B., Houx, P., & de Koning, I. (2003). Norms for Stroop Color Word Test, Trail Making Test, and story recall of Rivermead Behavioural Memory Test. Amsterdam, The Netherlands: Neuropsychology Section of the Dutch Institute for Psychologists.Google Scholar
Schwab, J.F. & England, A.C. (1969). Projection technique for evaluating surgery in Parkinson’s disease. In Gillingham, F.J. & Donaldson, M.C. (Eds.), Third symposium on Parkinson’s disease. Edinburgh, UK: E&S Livingstone.Google Scholar
Stroop, J.R. (1935). Studies of interference in serial verbal reactions. Journal of Experimental Psychology, 18, 643–662.Google Scholar
Wechsler, D. (1981). Wechsler Adult Intelligence Scale-Revised (WAIS-R). New York: Psychological Corporation.Google Scholar
Wechsler, D. (1997a). Wechsler Adult Intelligence Scale (WAIS-III) (3rd ed.). New York: Psychological Corporation.Google Scholar
Wechsler, D. (1997b). Wechsler Memory Scale (WMS-III) (3rd ed.). New York: Psychological Corporation.Google Scholar
Williams-Gray, C.H., Foltynie, T., Brayne, C.E.G., Robbins, T.W., & Barker, R.A. (2007). Evolution of cognitive dysfunction in an incident Parkinson’s disease cohort. Brain, 130, 1787–1798.CrossRefGoogle Scholar
Wilson, B., Cockburn, J., & Baddeley, A. (1985). Rivermead Behavioural Memory Test. Reading, UK: Thames Valley Test Company.Google Scholar
Zigmond, A.S. & Snaith, R.P. (1983). The Hospital Anxiety and Depression Scale. Acta Psychiatrica Scandinavica, 67, 361–370.CrossRefGoogle ScholarPubMed