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Association between Sleep Disordered Breathing and Nighttime Driving Performance in Mild Cognitive Impairment

Published online by Cambridge University Press:  24 April 2017

Nathan Cross ,
Zoe Terpening ,
Shantel L. Duffy ,
Simon J.G. Lewis ,
Ron Grunstein ,
Keith Wong  and
Sharon L. Naismith
Nathan Cross
Affiliation:
Healthy Brain Ageing Program, Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia Woolcock Institute of Medical Research, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia National Health and Medical Research Council, Centre of Research Excellence ‘Neurosleep’
Zoe Terpening
Affiliation:
Healthy Brain Ageing Program, Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia
Shantel L. Duffy
Affiliation:
Healthy Brain Ageing Program, Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia Woolcock Institute of Medical Research, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia National Health and Medical Research Council, Centre of Research Excellence ‘Neurosleep’ School of Psychology, Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia
Simon J.G. Lewis
Affiliation:
Healthy Brain Ageing Program, Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia Woolcock Institute of Medical Research, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia National Health and Medical Research Council, Centre of Research Excellence ‘Neurosleep’ Sydney Local Health District, Sydney, New South Wales, Australia
Ron Grunstein
Affiliation:
Woolcock Institute of Medical Research, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia National Health and Medical Research Council, Centre of Research Excellence ‘Neurosleep’ Sydney Local Health District, Sydney, New South Wales, Australia
Keith Wong
Affiliation:
Woolcock Institute of Medical Research, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia National Health and Medical Research Council, Centre of Research Excellence ‘Neurosleep’ Sydney Local Health District, Sydney, New South Wales, Australia
Sharon L. Naismith*
Affiliation:
Healthy Brain Ageing Program, Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia National Health and Medical Research Council, Centre of Research Excellence ‘Neurosleep’ School of Psychology, Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia
*
Correspondence and reprint requests to: Sharon L. Naismith, Healthy Brain Ageing Program, 94 Mallett Street, Camperdown NSW 2050, Australia. E-mail: [email protected]
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Abstract

Objectives: The effect of sleep disordered breathing (SDB) on driving performance in older adults has not been extensively investigated, especially in those with mild cognitive impairment (MCI). The aim of this study was to examine the relationship between severity measures of SDB and a simulated driving task in older adults with and without MCI. Methods: Nineteen older adults (age ≥50) meeting criteria for MCI and 23 age-matched cognitively intact controls underwent neuropsychological assessment and a driving simulator task in the evening before a diagnostic sleep study. Results: There were no differences in driving simulator performance or SDB severity between the two groups. In patients with MCI, a higher oxygen desaturation index (ODI) was associated with an increased number of crashes on the simulator task, as well as other driving parameters such as steering and speed deviation. Poorer driving performance was also associated with poorer executive functioning (set-shifting) but the relationship between ODI and crashes was independent of executive ability. Conclusions: While driving ability did not differ between older adults with and without MCI, oxygen saturation dips in MCI were related to worse driving performance. These results suggest that decreased brain integrity may render those with SDB particularly vulnerable to driving accidents. In older adults, both cognition and SDB need to be considered concurrently in relation to driving ability. (JINS, 2017, 23, 502–510)

Keywords

AgeingCognitionOSAApneaOxygenSimulator
Type
Special Section: Mild Cognitive Impairment
Information
Journal of the International Neuropsychological Society , Volume 23 , Issue 6 , July 2017 , pp. 502 - 510
Copyright
Copyright © The International Neuropsychological Society 2017 

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