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Neuropsychological Functioning in Girls with Premature Adrenarche

Published online by Cambridge University Press:  24 November 2011

A. Tissot ,
L.D. Dorn ,
D. Rotenstein ,
S.R. Rose ,
L.M. Sontag-Padilla ,
C.L. Jillard ,
S.F. Witchel ,
S.L. Berga ,
T.L. Loucks  and
S.R. Beers
A. Tissot*
Affiliation:
Division of Adolescent Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio University of Cincinnati College of Medicine, Cincinnati, Ohio
L.D. Dorn
Affiliation:
Division of Adolescent Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio University of Cincinnati College of Medicine, Cincinnati, Ohio
D. Rotenstein
Affiliation:
Pediatric Alliance, Pittsburgh, Pennsylvania
S.R. Rose
Affiliation:
University of Cincinnati College of Medicine, Cincinnati, Ohio Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
L.M. Sontag-Padilla
Affiliation:
RAND Corporation, Pittsburgh, Pennsylvania
C.L. Jillard
Affiliation:
Medical University of South Carolina, Charleston, South Carolina
S.F. Witchel
Affiliation:
Division of Endocrinology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania Department of Pediatrics, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania
S.L. Berga
Affiliation:
Department of Gynecology & Obstetrics, Emory University School of Medicine, Atlanta, Georgia
T.L. Loucks
Affiliation:
Department of Gynecology & Obstetrics, Emory University School of Medicine, Atlanta, Georgia
S.R. Beers
Affiliation:
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
*
Correspondence and reprint requests to: Abbigail Tissot, Division of Adolescent Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, ML 4000, Cincinnati, Ohio 45229-3039. E-mail: [email protected]
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Abstract

Contemporary research indicates that brain development occurs during childhood and into early adulthood, particularly in certain regions. A critical question is whether premature or atypical hormone exposures impact brain development (e.g., structure) or function (e.g., neuropsychological functioning). The current study enrolled 40 girls (aged 6–8 years) diagnosed with premature adrenarche (PA) and a comparison group of 36 girls with on-time maturation. It was hypothesized that girls with PA would demonstrate lower IQ and performance on several neuropsychological tasks. The potential for a sexually dimorphic neuropsychological profile in PA was also explored. No significant univariate or multivariate group differences emerged for any neuropsychological instrument. However, effect size confidence intervals contained medium-sized group differences at the subscale level. On-time girls performed better on verbal, working memory, and visuospatial tasks. Girls with PA showed improved attention, but not a sexually dimorphic profile. These results, though preliminary, suggest that premature maturation may influence neuropsychological functioning. (JINS, 2012, 18, 151–156)

Keywords

PubertyEndocrine system diseasesAdrenal cortex hormonesNeuropsychological testsSexual developmentSex characteristics
Type
Brief Communications
Information
Journal of the International Neuropsychological Society , Volume 18 , Issue 1 , January 2012 , pp. 151 - 156
Copyright
Copyright © The International Neuropsychological Society 2011

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References

Berenbaum, S.A., Beltz, A.M. (2011). Sexual differentiation of human behavior: Effects of prenatal and pubertal organizational hormones. Frontiers in Neuroendocrinology, 32, 183–200.CrossRefGoogle ScholarPubMed
Butters, N., Granholm, E., Salmon, D., Grant, I., Wolfe, J. (1987). Episodic and semantic memory: A comparison of amnestic and demented patients. Journal of Clinical and Experimental Neuropsychology, 9, 479–497.CrossRefGoogle ScholarPubMed
Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2nd ed.). Mahwah, NJ: Lawrence Erlbaum Associates.Google Scholar
Collaer, M.L., Geffner, M.E., Kaufman, F.R., Buckingham, B., Hines, M. (2002). Cognitive and behavioral characteristics of Turner Syndrome: Exploring a role for ovarian hormones in female sexual differentiation. Hormones and Behavior, 41, 139–155.CrossRefGoogle ScholarPubMed
Delis, D.C., Kramer, J.H., Kaplan, E., Ober, B.A. (1994). The California Verbal Learning Test-Children's Version. San Antonio, TX: Psychological Corporation.Google Scholar
Dorn, L.D., Hitt, S.F., Rotenstein, D. (1999). Biopsychological and cognitive difference in children with premature vs on-time adrenarche. Archives of Pediatric and Adolescent Medicine, 153, 137–146.CrossRefGoogle ScholarPubMed
Dorn, L.D., Rose, S.R., Rotenstein, D., Susman, E.J., Huang, B., Loucks, T.L., Berga, S.L. (2008). Differences in endocrine parameters and psychopathology in girls with premature adrenarche versus on-time adrenarche. Journal of Pediatric Endocrinology & Metabolism, 21, 439–448.CrossRefGoogle ScholarPubMed
Giedd, J.N. (2008). The teen brain: Insights from neuroimaging. Journal of Adolescent Health, 42, 335–343.CrossRefGoogle ScholarPubMed
Heaton, R.K., Chelune, G.J., Talley, J.L., Kay, G.G., Curtiss, G. (1993). Wisconsin card sorting test manual: Revised and expanded. Odessa, FL: Psychological Assessment Resources.Google Scholar
Hines, M. (2004). Brain gender. Oxford, UK: Oxford University Press.Google Scholar
Huttenlocher, P.R. (1999). Dendritic and synaptic development in human cerebral cortex: Time course and critical periods. Developmental Neuropsychology, 16, 347–349.CrossRefGoogle Scholar
Ibanez, L., DiMartino-Nardi, J., Potau, N., Saenger, P. (2000). Premature adrenarche – Normal variant or forerunner of adult disease? Endocrine Reviews, 21, 671–696.Google ScholarPubMed
Korkman, M., Kirk, U., Kemp, S. (2007). NEPSY-II: Administration manual. San Antonio, TX: Psychological Corporation.Google Scholar
Laakso, S., Utriainen, P., Laakso, M., Voutilainen, R., Jääskeläinen, J. (2010). Polymorphism Pro12Ala of PPARG in prepubertal children with premature adrenarche and its association with growth in healthy children. Hormone Research in Paediatrics, 74, 365–371.CrossRefGoogle ScholarPubMed
Lenroot, R.K., Giedd, J.N. (2010). Sex differences in the adolescent brain. Brain and Cognition, 72, 46–55.CrossRefGoogle ScholarPubMed
Lewis, R.F. (1995). Digit Vigilance Test. Odessa, FL: Psychological Assessment Resources.Google Scholar
Maninger, N., Wolkowitz, W.M., Reus, V.I., Epel, E., Mellon, S.H. (2009). Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS). Frontiers in Neuroendocrinology, 30, 65–91.CrossRefGoogle ScholarPubMed
Marshall, W.A., Tanner, J.M. (1969). Variations in pattern of pubertal changes in girls. Archives of Disease in Childhood, 44, 291–303.CrossRefGoogle ScholarPubMed
Mueller, S.C., Mandell, D., Leschek, E.W., Pine, D.S., Merke, D.P., Ernst, M. (2009). Early hyperandrogenism affects the development of hippocampal function: Preliminary evidence from a functional magnetic resonance imaging study of boys with familial male precocious puberty. Journal of Child and Adolescent Psychopharmacology, 19, 41–50.CrossRefGoogle ScholarPubMed
Nass, R., Baker, S., Sadler, A., Sidtis, J. (1990). The effects of precocious adrenarche on cognition and hemispheric specialization. Brain and Cognition, 14, 59–69.CrossRefGoogle ScholarPubMed
Osterrieth, P. (1993). The complex figure copy test. The Clinical Neuropsychologist, 7, 3–21.Google Scholar
Ritsner, M.S., Gibel, A., Ratner, Y., Tsinovoy, G., Strous, R.D. (2006). Improvement of sustained attention and visual and movement skills, but not clinical symptoms, after dehydroepiandrosterone augmentation in schizophrenia: A randomized, double-blind, placebo-controlled, crossover trial. Journal of Clinical Psychopharmacology, 26, 495–499.CrossRefGoogle Scholar
Rovet, J. (1983). Cognitive and neuropsychological test performance of persons with abnormalities of adolescent development: A test of Waber's hypothesis. Child Development, 54, 941–950.Google Scholar
Sattler, J.M., Saklofske, D.H. (2001). Wechsler Intelligence Scale for Chldren-III (WISC-III): Description. In J.M. Sattler (Ed.), Assessment of children: Cognitive applications (4th ed., pp. 220–263). La Mesa, CA: Sattler.Google Scholar
Schweinsburg, A.D., Nagel, B.J., Tapert, S.F. (2005). fMRI reveals alteration of spatial working memory networks across adolescence. Journal of the International Neuropsychological Society, 11, 631–644.CrossRefGoogle ScholarPubMed
Trites, R.L. (1977). Neuropsychological test manual: Instructions for the Grooved Pegboard Test. Ottawa, Ontario, Canada: Royal Ottawa Hospital.Google Scholar
Vanderploeg, R.D., Crowell, T.A., Curtiss, G. (2001). Verbal learning and memory deficits in traumatic brain injury: Encoding, consolidation, and retrieval. Journal of Clinical and Experimental Neuropsychology, 23, 185–195.CrossRefGoogle ScholarPubMed
Waber, D. (1976). Sex differences in cognition: A function of maturation rate? Science, 192, 572–574.CrossRefGoogle ScholarPubMed
Wechsler, D. (1991). Wechsler Intelligence Scale for Children (3rd ed.). San Antonio, TX: Psychological Corporation.Google Scholar
Whitford, T.J., Rennie, C.J., Grieve, S.M., Clark, C.R., Gordon, E., Williams, L.M. (2007). Brain maturation in adolescence: Concurrent changes in neuroanatomy and neurophysiology. Human Brain Mapping, 28, 228–237.CrossRefGoogle ScholarPubMed