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Neuropsychological Criteria for Mild Cognitive Impairment and Dementia Risk in the Framingham Heart Study

Published online by Cambridge University Press:  31 March 2016

Amy J. Jak ,
Sarah R. Preis ,
Alexa S. Beiser ,
Sudha Seshadri ,
Philip A. Wolf ,
Mark W. Bondi  and
Rhoda Au
Amy J. Jak*
Affiliation:
VA San Diego Healthcare System, San Diego, California Department of Psychiatry, University of California, San Diego, San Diego, California
Sarah R. Preis
Affiliation:
Framingham Heart Study, Framingham, Massachusetts Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts
Alexa S. Beiser
Affiliation:
Framingham Heart Study, Framingham, Massachusetts Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts Department of Neurology, Boston University School of Medicine, Boston, Massachusetts
Sudha Seshadri
Affiliation:
Framingham Heart Study, Framingham, Massachusetts Department of Neurology, Boston University School of Medicine, Boston, Massachusetts
Philip A. Wolf
Affiliation:
Framingham Heart Study, Framingham, Massachusetts Department of Neurology, Boston University School of Medicine, Boston, Massachusetts
Mark W. Bondi
Affiliation:
VA San Diego Healthcare System, San Diego, California Department of Psychiatry, University of California, San Diego, San Diego, California
Rhoda Au
Affiliation:
Framingham Heart Study, Framingham, Massachusetts Department of Neurology, Boston University School of Medicine, Boston, Massachusetts
*
Correspondence and reprint requests to: Amy Jak, 3350 La Jolla Village Drive, (116B), San Diego, CA 92161. E-mail: [email protected]
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Abstract

Objectives: To refine mild cognitive impairment (MCI) diagnostic criteria, we examined progression to dementia using two approaches to identifying MCI. Methods: A total of 1203 Framingham Heart Study participants were classified at baseline as cognitively normal or MCI (overall and four MCI subtypes) via conventional Petersen/Winblad criteria (single cognitive test impaired per domain, >1.5 SD below expectations) or Jak/Bondi criteria (two tests impaired per domain, >1 SD below norms). Cox proportional hazards models were constructed to examine the association between each MCI definition and incident dementia. Results: The Petersen/Winblad criteria classified 34% of participants as having MCI while the Jak/Bondi criteria classified 24% as MCI. Over a mean follow-up of 9.7 years, 58 participants (5%) developed incident dementia. Both MCI criteria were associated with incident dementia [Petersen/Winblad: hazards ratio (HR) = 2.64; p-value=.0002; Jak/Bondi: HR=3.30; p-value <.0001]. When both MCI definitions were included in the same model, only the Jak/Bondi definition remained statistically significantly associated with incident dementia (HR=2.47; p-value=.008). Multi-domain amnestic and single domain non-amnestic MCI subtypes were significantly associated with incident dementia for both diagnostic approaches (all p-values <.01). Conclusions: The Jak/Bondi MCI criteria had a similar association with dementia as the conventional Petersen/Winblad MCI criteria, despite classifying ~30% fewer participants as having MCI. Further exploration of alternative methods to conventional MCI diagnostic criteria is warranted. (JINS, 2016, 22, 937–943)

Keywords

Mild cognitive impairmentDiagnosisSubtypeCognitionDementiaLongitudinal
Type
Brief Communications
Information
Journal of the International Neuropsychological Society , Volume 22 , Issue 9 , October 2016 , pp. 937 - 943
Copyright
Copyright © The International Neuropsychological Society 2016 

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References

Albert, M., DeKosky, S.T., Dickson, D., Dubois, B., Feldman, H.H., Gamst, A., & Phelps, C.H. (2011). The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s and Dementia, 7, 270–279.CrossRefGoogle ScholarPubMed
Anstey, K.J., Cherbuin, N., Christensen, H., Burns, R., Reglade-Meslin, C., Salim, A., & Sachdev, P. (2008). Follow-up of mild cognitive impairment and related disorders over four years in adults in their sixties: The PATH trhough life study. Dementia and Geriatric Cognitive Disorders, 26, 226–233.Google Scholar
Au, R., Seshadri, S., Wolf, P.A., Elias, M., Elias, P., Sullivan, L., & D’Agostino, R.B. (2004). New norms for a new generation: Cognitive performance in the framingham offspring cohort. Experimental Aging Research, 30(4), 333–358.CrossRefGoogle ScholarPubMed
Bondi, M.W., Edmonds, E.C., Jak, A.J., Clark, L.R., Delano-Wood, L., McDonald, C.R., & Salmon, D.P. (2014). Neuropsychological criteria for mild cognitive impairment improves diagnostic precision, biomarker associations, and progression rates. Journal of Alzheimers Disease, 42(1), 275–289.Google Scholar
Bondi, M.W., & Smith, G.E. (2014). Mild cognitive impairment: A concept and diagnostic entity in need of input from neuropsychology. Journal of the International Neuropsychological Society, 20(2), 129–134.Google Scholar
Brooks, B.L., Iverson, G.L., Holdnack, J.A., & Feldman, H.H. (2008). Potential for misclassification of mild cognitive impairment: A study of memory scores on the Wechsler Memory Scale-III in healthy older adults. Journal of the International Neuropsychological Society, 14(3), 463–478. doi:10.1017/S1355617708080521 CrossRefGoogle ScholarPubMed
Chene, G., Beiser, A., Au, R., Preis, S.R., Wolf, P.A., Dufouil, C., &Seshadri, S. (2015). Gender and incidence of dementia in the Framingham Heart Study from mid-adult life. Alzheimers and Dementia, 11(3), 310–320. doi:10.1016/j.jalz.2013.10.005 CrossRefGoogle ScholarPubMed
Clark, L.R., Delano-Wood, L., Libon, D.J., McDonald, C.R., Nation, D.A., Bangen, K.J., & Bondi, M.W. (2013). Are empirically-derived subtypes of mild cognitive impairment consistent with conventional subtypes? Journal of the International Neuropsychological Society, 19, 635–645.Google Scholar
Edmonds, E.C., Delano-Wood, L., Clark, L.R., Jak, A.J., Nation, D.A., McDonald, C.R., & Bondi, M.W. (2015). Susceptibility of the conventional criteria for mild cognitive impairment to false positive diagnostic errors. Alzheimers and Dementia, 11, 415–424.Google Scholar
Edmonds, E.C., Delano-Wood, L., Galasko, D., Salmon, D.P., & Bondi, M.W. (2015). Subtle cognitive decline and biomarker staging in preclinical alzheime’s disease. Journal of Alzheimers Disease, 47, 231–242.CrossRefGoogle Scholar
Edmonds, E.C., Delano-Wood, L., Galasko, D., Salmon, D.P., & Bondi, M.W.; Alzheimer’s Disease Neuroimaging Initiative. (2014). Subjective cognitive complaints contribute to misdiagnosis of mild cognitive impairment. Journal of the International Neuropsychological Society, 20(8), 836–847.CrossRefGoogle ScholarPubMed
Feinleib, M., Kannel, W.B., Garrison, R.J., McNamara, P.M., & Castelli, W.P. (1975). The Framingham Offspring Study. Design and preliminary data. Preventative Medicine, 4, 518–525.Google Scholar
Fisk, J.D., Merry, H.R., & Rockwood, K. (2003). Variations in case definition affect prevalence but not outcomes of mild cognitive impairment. Neurology, 31, 1179–1184.Google Scholar
Ganguli, M., Snitz, B.E., Saxton, J.A., Chang, C.C., Lee, C.W., Vander Bilt, J., & Petersen, R.C. (2011). Outcomes of mild cognitive impairment by definition: A population study. Archives of Neurology, 68, 761–767.Google Scholar
Hänninen, T., Hallikainen, M., Tuomainen, S., Vanhanen, M., & Soininen, H. (2002). Prevalence of mild cognitive impairment: A population-based study in elderly subjects. Acta Neurologica Scandinavica, 106(3), 148–154. Retrieved from http://dx.doi.org/10.1034/j.1600-0404.2002.01225.x Google Scholar
Heaton, R.K., Miller, S.W., Taylor, M.J., & Grant, I. (2004). Revised comprehensive norms for an expanded Halstead-Reitan Battery: Demographically adjusted neuropsychological norms for African American and Caucasian adults Scoring Program. Odessa, FL: Psychological Assessment Resources, Inc.Google Scholar
Jak, A.J., Bondi, M.W., Delano-Wood, L., Wierenga, C.E., Corey-Bloom, J., Salmon, D.P., & Delis, D. (2009). Quantification of five neuropsychological approaches to defining mild cognitive impairment. American Journal of Geriatric Psychiatry, 17, 368–375.Google Scholar
Jak, A.J., Urban, S., McCauley, A., Bangen, K.J., Delano-Wood, L., Corey-Bloom, J., & Bondi, M.W. (2009). Profile of hippocampal volumes and stroke risk varies by neuropsychological definition of mild cognitive impairment. Journal of the International Neuropsychological Society, 2, 1–8.Google Scholar
Kaplan, E.F., Goodglass, H., & Weintraub, S. (1983). The Boston Naming Test. Philadelphia: Lea & Febiger.Google Scholar
Litvan, I., Goldman, J.G., Troster, A.I., Schmand, B.A., Weintraub, D., Petersen, R.C., & Emre, M. (2012). Diagnostic criteria for mild cognitive impairment in Parkinson’s disease: Movement Disorder Society Task Force guidelines. Movement Disorders, 27, 349–356.Google Scholar
Loewenstein, D.A., Acevedo, A., Small, B.J., Agron, J., Crocco, E., & Duara, R. (2009). Stability of different subtypes of mild cognitive impairment among the elderly over a 2–3 year follow-up period. Dementia and Geriatric Cognitive Disorders, 27(5), 418–423.Google Scholar
McKeith, I.G., Perry, E.K., & Perry, R.H. (1999). Report of the second dementia with Lewy body international workshop: Diagnosis and treatment. Consortium on Dementia with Lewy Bodies. Neurology, 53(5), 902–905.Google Scholar
McKhann, G.M., Knopman, D.S., Chertkow, H., Hyman, B.T., Jack, C.R. Jr., Kawas, C.H., & Phelps, C.H. (2011). The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers and Dementia, 7(3), 263–269. doi:10.1016/j.jalz.2011.03.005 Google Scholar
Miller, B.L., Ikonte, C., Ponton, M., Levy, M., Boone, K., Darby, A., & Cummings, J.L. (1997). A study of the Lund-Manchester research criteria for frontotemporal dementia: Clinical and single-photon emission CT correlations. Neurology, 48(4), 937–942.Google Scholar
Petersen, R.C., Smith, G.E., Waring, S.C., Ivnik, R.J., Tangalos, E.G., & Kokmen, E. (1999). Mild cognitive impairment: Clinical characterization and outcome. Archives of Neurology, 56(3), 303–308. Retrieved from http://archneur.ama-assn.org/cgi/content/abstract/56/3/303 Google Scholar
Reitan, R.M., & Wolfson, D. (1985). The Halstead-Reitan Neuropsychological Test Battery. Tucson, AZ: Neuropsychology Press.Google Scholar
Roman, G.C., Tatemichi, T.K., Erkinjuntti, T., Cummings, J.L., Masdeu, J.C., Garcia, J.H., & Scheinberg, P. (1993). Vascular dementia: Diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology, 43, 250–260.CrossRefGoogle ScholarPubMed
Salmon, D.P., & Bondi, M.W. (2009). Neuropsychological Assessment of Dementia. Annual Review of Psychology, 60, 257–282.Google Scholar
Smith, G.E., & Bondi, M.W. (2013). Mild cognitive impairment and dementia: Definitions, diagnosis, and treatment. New York: Oxford University Press.Google Scholar
Sperling, R.A., Aisen, P.S., Beckett, L.A., Bennett, D.A., Craft, S., Fagan, A.M., & Phelps, C.H. (2011). Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s and Dementia, 7(3), 280–292.Google Scholar
Trittschuh, E.H., Crane, P.K., Larson, E.B., Cholerton, B., McCormick, W.C., McCurry, S.M., & Craft, S. (2011). Effects of varying diagnostic criteria on prevalence of mild cognitive impairment in a community sample. Journal of Alzheimers Disease, 25(1), 163–173.Google Scholar
Wechsler, D. (1981). Wechsler Adult Intelligence Scale-Revised Manual. San Antonio: The Psychological Corporation.Google Scholar
Wechsler, D. (1987). Wechsler Memory Scale – Revised. New York: Psychological Corporation.Google Scholar