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Neurocognition in Psychometrically Defined College Schizotypy Samples: We Are NOT Measuring the “Right Stuff”

Published online by Cambridge University Press:  01 March 2013

Charlotte A. Chun ,
Kyle S. Minor  and
Alex S. Cohen
Charlotte A. Chun
Affiliation:
Department of Psychology, Louisiana State University, Baton Rouge, Louisiana
Kyle S. Minor
Affiliation:
Department of Psychology, Louisiana State University, Baton Rouge, Louisiana
Alex S. Cohen*
Affiliation:
Department of Psychology, Louisiana State University, Baton Rouge, Louisiana
*
Correspondence and reprint requests to: Alex Cohen, Louisiana State University, Department of Psychology, 236 Audubon Hall, Baton Rouge, LA 70803. E-mail: [email protected]
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Abstract

Although neurocognitive deficits are an integral characteristic of schizophrenia, there is inconclusive evidence as to whether they manifest across the schizophrenia-spectrum. We conducted two studies and a meta-analysis comparing neurocognitive functioning between psychometrically defined schizotypy and control groups recruited from a college population. Study One compared groups on measures of specific and global neurocognition, and subjective and objective quality of life. Study Two examined working memory and subjective cognitive complaints. Across both studies, the schizotypy group showed notably decreased subjective (d = 1.52) and objective (d = 1.02) quality of life and greater subjective cognitive complaints (d = 1.88); however, neurocognition was normal across all measures (d's < .35). Our meta-analysis of 33 studies examining neurocognition in at-risk college students revealed between-group differences in the negligible effect size range for most domains. The schizotypy group demonstrated deficits of a small effect size for working memory and set-shifting abilities. Although at-risk individuals report relatively profound neurocognitive deficits and impoverished quality of life, neurocognitive functioning assessed behaviorally is largely intact. Our data suggest that traditionally defined neurocognitive deficits do not approximate the magnitude of subjective complaints associated with psychometrically defined schizotypy. (JINS, 2013, 19, 1–14)

Keywords

Risk markerPsychopathologyQuality of lifeMeta-analysisFunctioningStudents
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 19 , Issue 3 , March 2013 , pp. 324 - 337
Copyright
Copyright © The International Neuropsychological Society 2013

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References

Aguirre, F., Sergi, M., Levy, C. (2008). Emotional intelligence and social functioning in persons with schizotypy. Schizophrenia Research, 104(1–3), 255–264.CrossRefGoogle ScholarPubMed
Asarnow, R., Nuechterlein, K., Asamen, J., Fogelson, D., Subotnik, K.L., Zaucha, K., Guthrie, D. (2002). Neurocognitive functioning and schizophrenia spectrum disorders can be independent expressions of familial liability for schizophrenia in community control children: The UCLA family study. Schizophrenia Research, 54(1), 111–120.CrossRefGoogle ScholarPubMed
Chan, R., Yan, C., Qing, Y.-H., Wang, Y., Wang, Y.-N., Ma, Z., Yu, X. (2011). Subjective awareness of everyday dysexecutive behavior precedes ‘objective’ executive problems in schizotypy: A replication and extension study. Psychiatry Research, 185, 340–346.CrossRefGoogle ScholarPubMed
Chang, B.P., Lenzenweger, M.F. (2004). Investigating graphesthesia task performance in the biological relatives of schizophrenia patients. Schizophrenia Bulletin, 30, 327–334.CrossRefGoogle ScholarPubMed
Chaplin, R., Barley, M., Cooper, S., Kusel, Y., McKendrick, J., Stephenson, D., Burns, T. (2006). The impact of intellectual functioning on symptoms and service use in schizophrenia. Journal of Intellectual Disability Research, 50(4), 288–294.CrossRefGoogle ScholarPubMed
Chapman, L.J., Chapman, J.P. (1983). Infrequency scale. Madison, WI: Unpublished test.Google Scholar
Chapman, L.J., Chapman, J.P., Kwapil, T., Eckblad, M., Zinser, M. (1994;1965). Putatively psychosis-prone subjects 10 years later. Journal of Abnormal Psychology, 103(2), 171–183.CrossRefGoogle ScholarPubMed
Chapman, L.J., Chapman, J.P., Raulin, M.L. (1978). Body image aberration in schizophrenia. Journal of Abnormal Psychology, 87, 399–407.CrossRefGoogle ScholarPubMed
Cohen, A.S., Davis, T.E. (2009). Quality of life across the schizotypy spectrum: findings from a large healthy adult sample. Comprehensive Psychiatry, 50, 408–414.CrossRefGoogle Scholar
Cohen, A.S., Hong, S.L. (2011). Understanding constricted affect in schizotypy through computerized prosodic analysis. Journal of Personality Disorders, 25(4), 478–491.CrossRefGoogle ScholarPubMed
Cohen, A.S., Iglesias, B., Minor, K. (2009). The neurocognitive underpinnings of diminished expressivity in schizotypy: What the voice reveals. Schizophrenia Research, 109(1–3), 38–45.CrossRefGoogle ScholarPubMed
Cohen, A.S., Leung, W.W., Saperstein, A.M., Blanchard, J.J. (2006). Neuropsychological functioning and social anhedonia: Results from a community high-risk study. Schizophrenia Research, 85, 132–141.CrossRefGoogle ScholarPubMed
Cohen, A.S., Matthews, R., Najolia, G., Brown, L.A. (2010). Psychometrically-sound brief measure of schizotypy: Improving the SPQ-B. Journal of Personality Disorders, 24, 516–537.CrossRefGoogle Scholar
Cohen, A.S., Najolia, G.M. (2011). Birth characteristics and schizotypy: Evidence of a potential “Second Hit”. Journal of Psychiatric Research, 45(7), 955–961.CrossRefGoogle ScholarPubMed
Cohen, A.S., Saperstein, A.M., Gold, J.M., Kirkpatrick, B., Carpenter, W.T. Jr., Buchanan, R.W. (2007). Neuropsychology of the deficit syndrome: New data and meta-analysis of findings to date. Schizophrenia Bulletin, 33(5), 1201–1212.CrossRefGoogle ScholarPubMed
Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2nd ed.). New Jersey: Lawrence Erlbaum Associates.Google Scholar
Dinn, W.M., Harris, C.L., Aycicegi, A., Greene, P., Andover, M.S. (2002). Positive and negative schizotypy in a student sample: Neuro-cognitive and clinical correlates. Schizophrenia Research, 56, 171–185.CrossRefGoogle Scholar
Eckblad, M.L., Chapman, L.J. (1983). Magical ideation as an indicator of schizotypy. Journal of Consulting and Clinical Psychology, 51, 215–225.CrossRefGoogle ScholarPubMed
Eckblad, M.L., Chapman, L.J., Chapman, J.P., Mishlove, M. 1982. The revised social anhedonia scale. Unpublished test.Google Scholar
Fonseca-Pedrero, E., Paíno-Piñeiro, M., Lemos-Giráldez, S., Villazón-García, U., Muñiz, J. (2009). Validation of the Schizotypal Personality Questionnaire—Brief Form in adolescents. Schizophrenia Research, 111, 53–60.CrossRefGoogle ScholarPubMed
Garlinghouse, M.A., Roth, R.M., Isquith, P.K., Flashman, L.A., Saykin, A.J. (2010). Subjective rating of working memory is associated with frontal lobe volume in schizophrenia. Schizophrenia Research, 120(1–3), 71–75.CrossRefGoogle ScholarPubMed
Gold, J., Queern, C., Iannone, V., Buchanan, R. (1999). Repeatable battery for the assessment of neuropsychological status as a screening test in schizophrenia, I: Sensitivity, reliability, and validity. The American Journal of Psychiatry, 156(12), 1944–1950.CrossRefGoogle ScholarPubMed
Gooding, D., Braun, J. (2004). Visuoconstructive performance, implicit hemispatial inattention, and schizotypy. Schizophrenia Research, 68(2), 261–269.CrossRefGoogle ScholarPubMed
Gooding, D., Kwapil, T., Tallent, K. (1999). Wisconsin Card Sorting Test deficits in schizotypic individuals. Schizophrenia Research, 40(3), 201–209.CrossRefGoogle ScholarPubMed
Grant, P.M., Beck, A.T. (2009). Defeatist beliefs as a mediator of cognitive impairment, negative symptoms and functioning in schizophrenia. Schizophrenia Bulletin, 35, 798–806.CrossRefGoogle ScholarPubMed
Green, M.F. (1996). What are the functional consequences of neurocognitive deficits in schizophrenia? The American Journal of Psychiatry, 153(3), 321–330.Google ScholarPubMed
Green, M.F., Kern, R.S., Braff, D.L., Mintz, J. (2000). Neurocognitive deficits and functional outcome in schizophrenia: Are we measuring the “right stuff”? Schizophrenia Bulletin, 26(1), 119–136.CrossRefGoogle ScholarPubMed
Gur, R.E., Nimgaonkar, V., Almasy, L., Calkins, M.E., Ragland, J.D., Pogue-Geile, M.F., Gur, R.C. (2007). Neurocognitive endophenotypes in a multiplex multigenerational family study of schizophrenia. The American Journal of Psychiatry, 164(5), 813–819.CrossRefGoogle Scholar
Heinrichs, R., Zakzanis, K. (1998). Neurocognitive deficit in schizophrenia: A quantitative review of the evidence. Neuropsychology, 2(3), 426–445.CrossRefGoogle Scholar
Holzer, L., Chinet, L., Jaugey, L., Plancherel, B., Sophia, C., Halfon, O., Randolph, C. (2007). Detection of cognitive impairment with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) in adolescents with psychotic symptomatology. Schizophrenia Research, 95, 48–53.CrossRefGoogle ScholarPubMed
Horan, W.P., Braff, D.L., Nuechterlein, K.H., Sugar, C.A., Cadenhead, K.S., Calkins, M.E., Green, M.F. (2008). Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: Findings from the Consortium on the Genetics of Schizophrenia. Schizophrenia Research, 103, 218–228.CrossRefGoogle Scholar
Kern, R.S., Nuechterlein, K.H., Green, M.F., Baade, L.E., Fenton, W.S., Gold, J.M., Marder, S.R. (2008). The MATRICS Consensus Cognitive Battery, Part 2: Co-norming and standardization. The American Journal of Psychiatry, 165(2), 214–220.CrossRefGoogle ScholarPubMed
Killam, C., Cautin, R.L., Santucci, A.C. (2005). Assessing the enduring residual neuropsychological effects of head trauma in college athletes who participate in contact sports. Archives of Clinical Neuropsychology, 20, 599–611.CrossRefGoogle ScholarPubMed
Laws, K.R., Patel, D.D., Tyson, P.J. (2008). Awareness of everyday executive difficulties precede overt executive dysfunction in schizotypal subjects. Psychiatry Research, 160, 8–14.CrossRefGoogle ScholarPubMed
Lehman, O.F. (1995). Measuring quality of life in a reformed health system. Health Affairs (Millwood), 14, 90–101.CrossRefGoogle Scholar
Lenzenweger, M.F. (2001). Reaction time slowing during high-load, sustained-attention task performance in relation to psychometrically identified schizotypy. Journal of Abnormal Psychology, 110(2), 290–296.CrossRefGoogle ScholarPubMed
Lenzenweger, M.F. (2006). Schizotypy: An organizing framework for schizophrenia research. Current Directions in Psychological Science, 15(4), 162–166.CrossRefGoogle Scholar
Lenzenweger, M.F., Gold, J. (2000). Auditory working memory and verbal recall memory in schizotypy. Schizophrenia Research, 42(2), 101–110.CrossRefGoogle ScholarPubMed
Lenzenweger, M.F., Korfine, L. (1992). Confirming the latent structure and base rate of schizotypy: A taxometric analysis. Journal of Abnormal Psychology, 101, 567–571.CrossRefGoogle ScholarPubMed
McNair, D.M., Kahn, R.J. (1984). Self-assessment of cognitive deficits. In T. Crook, S. Ferris, & R. Bartus (Eds.), Assessment in geriatric psychopharmacology. New Canaan, CT: Mark Powley.Google Scholar
Meehl, P. (1962). Schizotaxia, schizotypy, schizophrenia. American Psychologist, 17(12), 827–838.CrossRefGoogle Scholar
Minor, K., Cohen, A. (2010). Affective reactivity of speech disturbances in schizotypy. Journal of Psychiatric Research, 44(2), 99–105.CrossRefGoogle ScholarPubMed
Miyake, A., Friedman, N.P., Emerson, M.J., Witzki, A.H., Howerter, A. (2000). The unity and diversity of executive functions and their contributions to complex ‘‘frontal lobe’’ tasks: A latent variable analysis. Cognitive Psychology, 41, 49–100.CrossRefGoogle ScholarPubMed
Moser, R.S., Schatz, P. (2002). Enduring effects of concussion in youth athletes. Archives of Clinical Neuropsychology, 17, 91–100.CrossRefGoogle ScholarPubMed
Nuechterlein, K.H., Green, M.F., Kern, R.S., Baade, L.E., Barch, D.M., Cohen, J.D., Marder, S.R. (2008). The MATRICS consensus cognitive battery, Part 1: Test selection, reliability and validity. The American Journal of Psychiatry, 165(2), 203–213.CrossRefGoogle ScholarPubMed
Patel, A., Everitt, B., Knapp, M., Reeder, C., Grant, D., Ecker, C., Wykes, T. (2006). Schizophrenia patients with cognitive deficits: Factors associated with costs. Schizophrenia Bulletin, 32(4), 776–785.CrossRefGoogle ScholarPubMed
Peltier, B.D., Walsh, J.A. (1990). An investigation of response bias in the Chapman Scales. Educational and Psychological Measurement, 50, 803–815.CrossRefGoogle Scholar
Poreh, A., Ross, T., Whitman, R. (1995). Reexamination of executive functions in psychosis-prone college students. Personality and Individual Differences, 18(4), 535–539.CrossRefGoogle Scholar
Raine, A. (1991). The SPQ: A scale for the assessment of schizotypal personality based on DSM-I-R criteria. Schizophrenia Bulletin, 17, 555–564.CrossRefGoogle ScholarPubMed
Raine, A., Benishay, D. (1995). The SPQ-B: A brief screening instrument for schizotypal personality disorder. Journal of Personality Disorders, 9, 346–355.CrossRefGoogle Scholar
Randolph, C. (1998). RBANS manual—Repeatable battery for the assessment of neuropsychological status. San Antonio, TX: Harcourt.Google ScholarPubMed
Ritsner, M. (2007). Predicting quality of life impairment in chronic schizophrenia from cognitive variables. Quality of Life Research, 16(6), 929–937.CrossRefGoogle ScholarPubMed
Rosenberg, M.S., Adams, D.C., Gurevitch, J. (2000). MetaWin: Statistical software for meta-analysis. Sunderland, MA: Sinauer Associates, Inc.Google Scholar
Saykin, A., Shtasel, D., Gur, R., Kester, D. (1994). Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia. Archives of General Psychiatry, 51(2), 124–131.CrossRefGoogle ScholarPubMed
Trestman, R., Keefe, R., Mitropoulou, V., Harvey, P.D., DeVegvar, M.L., Lees-Roitman, S., Siever, J. (1995). Cognitive function and biological correlates of cognitive performance in schizotypal personality disorder. Psychiatry Research, 59(1), 127–136.CrossRefGoogle ScholarPubMed
Vollema, M.G., Postma, B. (2002). Neurocognitive correlates of schizotypy in first-degree relatives of schizophrenia patients. Schizophrenia Bulletin, 28(3), 367–377.CrossRefGoogle ScholarPubMed
Wechsler, D. (1997a). Wechsler Adult Intelligence Scale (3rd ed.). San Antonio, TX: Harcourt.Google Scholar
Wechsler, D. (1997b). Wechsler Memory Scale-III Technical Manual. San Antonio, TX: Harcourt.Google Scholar
Wuthrich, V., Bates, T.C. (2005). Reliability and validity of two Likert versions of the Schizotypal Personality Questionnaire (SPQ). Personality and Individual Differences, 38, 1543–1548.CrossRefGoogle Scholar
Wuthrich, V., Bates, T.C. (2006). Confirmatory factor analysis of the 3 factor structure of the schizotypal personality questionnaire and Chapman Schizotypy Scales. Journal of Personality Assessment, 87(3), 292–304.CrossRefGoogle ScholarPubMed