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Neural Correlates of Interference Control in Adolescents with Traumatic Brain Injury: Functional Magnetic Resonance Imaging Study of the Counting Stroop Task

Published online by Cambridge University Press:  19 November 2010

Sarah J. Tlustos ,
C.-Y. Peter Chiu ,
Nicolay Chertkoff Walz ,
Scott K. Holland ,
Lori Bernard  and
Shari L. Wade
Sarah J. Tlustos
Affiliation:
Department of Psychology, University of Cincinnati, Cincinnati, Ohio
C.-Y. Peter Chiu*
Affiliation:
Department of Psychology, University of Cincinnati, Cincinnati, Ohio Department of Communication Sciences and Disorders, University of Cincinnati, Cincinnati, Ohio
Nicolay Chertkoff Walz
Affiliation:
Division of Behavioral Medicine and Clinical Psychology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center University of Cincinnati College of Medicine, Cincinnati, Ohio
Scott K. Holland
Affiliation:
University of Cincinnati College of Medicine, Cincinnati, Ohio Cincinnati Children’s Hospital Research Foundation, Department of Radiology, Cincinnati Children’s Hospital Medical Center
Lori Bernard
Affiliation:
Division of Physical Medicine and Rehabilitation, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
Shari L. Wade
Affiliation:
University of Cincinnati College of Medicine, Cincinnati, Ohio Division of Physical Medicine and Rehabilitation, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
*
Correspondence and reprint requests to: Peter Chiu, Department of Psychology, University of Cincinnati, 101A Dyer Hall, ML 0376, Cincinnati, OH 45221-0376. E-mail: [email protected]
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Abstract

Difficulty in inhibition or cognitive control is a common and significant sequela of pediatric traumatic brain injury (TBI). The present study used functional MRI to examine one specific inhibitory function, interference control, in 11 adolescents, aged 12–16 years, (mean age, 15.7 years) with TBI who were at least 1 year postinjury and 11 age-matched typically developing control participants (TC) (mean age, 15.2 years). Participants completed a Counting Stroop task with 2 main conditions: (1) a neutral condition requiring the counting of animal words and (2) an interference condition in which mismatched number words were counted. Both TBI and TC adolescents activated similar networks of brain regions relevant to interference control, but the TBI group showed higher levels of activation relative to the TC group in multiple brain areas within this network, including predominantly right frontal and parietal regions. Findings of greater activation of the relevant neural network in the TBI group are consistent with recent fMRI findings using other interference control paradigms with individuals with a history of TBI. (JINS, 2011, 17, 000–000.)

Keywords

Childhood brain disorderInhibitionExecutive functionsBrain imagingAdolescentHead injury
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 17 , Issue 1 , January 2011 , pp. 181 - 189
Copyright
Copyright © The International Neuropsychological Society 2010

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