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Memory and insulin dependent diabetes mellitus (IDDM): Effects of childhood onset and severe hypoglycemia

Published online by Cambridge University Press:  01 November 1997

TAMARA HERSHEY ,
SUZANNE CRAFT ,
NEIL BHARGAVA  and
NEIL H. WHITE
TAMARA HERSHEY
Affiliation:
Department of Psychology, Washington University in St. Louis
SUZANNE CRAFT
Affiliation:
The Geriatric Research, Education and Clinical Center of the Seattle–American Lake VA Medical Center, and Department of Psychiatry and Behavioral Sciences, University of Washington
NEIL BHARGAVA
Affiliation:
Department of Psychology, Washington University in St. Louis
NEIL H. WHITE
Affiliation:
Division of Endocrinology and Metabolism, Department of Pediatrics, Washington University School of Medicine
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Abstract

Previous studies of the neuropsychological consequences of insulin dependent diabetes mellitus (IDDM) have had mixed and often contradictory results, possibly due to the heterogeneity of the samples and neuropsychological measures, and a lack of specific hypotheses. In order to address this problem, we focused on the effect of severe hypoglycemia on memory functioning in a relatively homogeneous sample of childhood-onset IDDM patients. Given the deleterious effects of hypoglycemia on medial temporal lobe structures (e.g., hippocampus) and the relationship between medial temporal damage and declarative memory functioning, we hypothesized that those patients who had experienced severe hypoglycemia would demonstrate impaired declarative memory and spared nondeclarative memory functioning. Results of the study were generally consistent with this hypothesis, although some impact of hypoglycemia was observed on perceptual priming ability. (JINS, 1997, 3, 509–520.)

Keywords

DiabetesMemoryHypoglycemia
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 3 , Issue 6 , November 1997 , pp. 509 - 520
Copyright
© 1997 The International Neuropsychological Society

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