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Hippocampus volume and episodic memory in schizophrenia

Published online by Cambridge University Press:  01 March 2009

ROBERT J. THOMA ,
MOLLIE MONNIG ,
FAITH M. HANLON ,
GREGORY A. MILLER ,
HELEN PETROPOULOS ,
ANDREW R. MAYER ,
RON YEO ,
MATT EULER ,
PER LYSNE  and
SANDRA N. MOSES
...Show all authors
ROBERT J. THOMA*
Affiliation:
Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, New Mexico MIND Research Network (MRN), Albuquerque, New Mexico Department of Psychology, University of New Mexico, Albuquerque, New Mexico
MOLLIE MONNIG*
Affiliation:
MIND Research Network (MRN), Albuquerque, New Mexico Department of Psychology, University of New Mexico, Albuquerque, New Mexico
FAITH M. HANLON
Affiliation:
Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, New Mexico MIND Research Network (MRN), Albuquerque, New Mexico
GREGORY A. MILLER
Affiliation:
Departments of Psychology, Psychiatry, and the Beckman Institute, University of Illinois–Urbana-Champaign, Urbana-Champaign, Illinois
HELEN PETROPOULOS
Affiliation:
Neuroimaging Research Group, Department of Radiology, University of Washington, Seattle, Washington
ANDREW R. MAYER
Affiliation:
MIND Research Network (MRN), Albuquerque, New Mexico
RON YEO
Affiliation:
MIND Research Network (MRN), Albuquerque, New Mexico Department of Psychology, University of New Mexico, Albuquerque, New Mexico
MATT EULER
Affiliation:
MIND Research Network (MRN), Albuquerque, New Mexico Department of Psychology, University of New Mexico, Albuquerque, New Mexico
PER LYSNE
Affiliation:
MIND Research Network (MRN), Albuquerque, New Mexico Department of Psychology, University of New Mexico, Albuquerque, New Mexico
SANDRA N. MOSES
Affiliation:
Rotman Research Institute, Toronto, Ontario, Canada
JOSE M. CAÑIVE
Affiliation:
Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, New Mexico New Mexico Veteran Affairs Health Care System (NMVAHCS), Albuquerque, New Mexico
*
*Correspondence and reprint requests to: Robert J. Thoma, Ph.D., Center for Neuropsychological Services, MSC 11 6094, 1 University of New Mexico, 915 Vassar NE, Albuquerque, New Mexico 87131. E-mail: [email protected]
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Abstract

Previous studies of schizophrenia have suggested a linkage between neuropsychological (NP) deficits and hippocampus abnormality. The relationship between hippocampus volume and NP functioning was investigated in 24 patients with chronic schizophrenia and 24 matched healthy controls. Overall intracranial, white and gray matter, and anterior (AH) and posterior (PH) hippocampus volumes were assessed from magnetic resonance images (MRI). NP domains of IQ, attention, and executive function were also evaluated with respect to volumetric measures. It was hypothesized that AH and PH volumes and episodic memory scores would be positively associated in controls and that the schizophrenia group would depart from this normative pattern. NP functioning was impaired overall and AH volume was smaller in the schizophrenia group. In the controls, the hippocampus–memory relationships involved AH and PH, and correlations were significant for verbal memory measures. In the schizophrenia group, positive correlations were constrained to PH. Negative correlations emerged between AH and verbal and visual memory measures. For both groups, cortical volume negatively correlated with age, but a negative correlation between age and hippocampus volume was found only in the schizophrenia group. In this sample of adults with schizophrenia, atypical relationships between regional hippocampus volumes and episodic memory ability were found, as was an atypical negative association between hippocampus volume and age. (JINS, 2009, 15, 182–195.)

Keywords

Magnetic resonance imagingCognitionNeuropsychologyMemoryTemporal lobeAntipsychotic agents
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 15 , Issue 2 , March 2009 , pp. 182 - 195
Copyright
Copyright © INS 2009

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