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Hepatic calcifications in fetal population studied by autopsies in Bogota, Colombia

Published online by Cambridge University Press:  23 May 2017

M. Olaya-C ,
S. Aldana-M ,
M. Maya-G  and
F. Gil
M. Olaya-C*
Affiliation:
Department of Pathology, Pontificia Universidad Javeriana, Bogota, Colombia Department of Pathology, Hospital Universitario San Ignacio, Bogota, Colombia
S. Aldana-M
Affiliation:
Medical School, Research seedbed in Perinatal Medicine, Pontificia Universidad Javeriana, Bogota, Colombia
M. Maya-G
Affiliation:
Medical School, Research seedbed in Perinatal Medicine, Pontificia Universidad Javeriana, Bogota, Colombia
F. Gil
Affiliation:
Department of Clinical Epidemiology and Biostatistics, Pontificia Universidad Javeriana, Bogota, Colombia
*
*Address for correspondence: M. Olaya-C, Department of Pathology, Pontificia Universidad Javeriana, Kra 7 40-62, Bogota 11321, Colombia. (Email [email protected])
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Abstract

Fetal hepatic calcifications can be caused by infections, chromosomal disorders, thrombotic events, ischemic hepatic necrosis and subcapsular hematomas among others events. Its features and clinical significance are still not well known. We performed an observational study to describe fetal hepatic calcifications and its association with main clinical and histopathological findings from the fetal autopsy database, between 2007 and 2014. Raw odds ratio analysis was performed. We reviewed 591 fetal autopsies: 14 cases with hepatic calcifications, 102 fetuses with chromosomal disorders; 13 with diagnosis of TORSCH (toxoplasma, rubella, syphilis, cytomegalovirus, herpes virus 1 and 2, and others) and 207 with any abnormality in the umbilical cord (UC). The relation between hepatic calcifications and chromosomal disorders in our series had significance. It is known that hepatic calcifications are common in chromosomal disorders, transplacental infections and UC abnormalities, those conditions are risk factor for hepatic calcifications formation; we suggest hepatic calcifications should alert the pathologists in order to consider these etiologies in first instance.

Keywords

chromosome abnormalityfetal thrombotic vasculopathyintrauterine infectionliver calcificationliver diseases
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 8 , Issue 5: Themed Issue: Australian Perspectives: Outcomes from the 2016 ANZ , October 2017 , pp. 613 - 617
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2017 

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References

1. Simchen, MJ, Toi, A, Bona, M, et al. Fetal hepatic calcifications: prenatal diagnosis and outcome. Am J Obstet Gynecol. 2002; 187, 1617–1622.CrossRefGoogle ScholarPubMed
2. Redline, RW, Pappin, A. Fetal thrombotic vasculopathy: the clinical significance of extensive avascular villi. Hum Pathol. 1995; 26, 80–85.CrossRefGoogle ScholarPubMed
3. Viero, S, Chaddha, V, Alkazaleh, F, et al. Prognostic value of placental ultrasound in pregnancies complicated by absent end-diastolic flow velocity in the umbilical arteries. Placenta. 2004; 25, 735–741.CrossRefGoogle ScholarPubMed
4. Williams, S, Chan, AKC. Neonatal portal vein thrombosis: diagnosis and management. Semin Fetal Neonatal Med. 2011; 16, 329–339.CrossRefGoogle ScholarPubMed
5. Nguyen, DL, Leonard, JC. Ischemic hepatic necrosis: a cause of fetal liver calcification. AJR Am J Roentgenol. 1986; 147, 596–597.CrossRefGoogle ScholarPubMed
6. Buxton, PJ, Maheswaran, P, Dewbury, KC, Moore, IE. Neonatal hepatic calcification in subcapsular haematoma with hydrops fetalis. Br J Radiol. 1991; 64, 1058–1060.CrossRefGoogle ScholarPubMed
7. Kaplan, C. Normal values for placentas. In Color Atlas of Gross Placental Pathology (ed. Kaplan CG), 2nd edn, 2007; pp. 119–122. Springer: New York.Google Scholar
8. Baergen, RN. Pathology of the umbilical cord. In Manual of and Kaufmann’s Pathology of the Human Placenta (ed. Baergen RN), 1st edn, 2005; pp. 249–276. Springfield: New York, NY.Google Scholar
9. Predanic, M, Perni, SC, Chasen, ST, Baergen, RN, Chervenak, FA. Assessment of umbilical cord coiling during the routine fetal sonographic anatomic survey in the second trimester. J Ultrasound Med. 2005; 24, 185–191.CrossRefGoogle ScholarPubMed
10. Rittler, M, Mazzitelli, N, Fuksman, R, de Rosa, LG, Grandi, C. Single umbilical artery and associated malformations in over 5500 autopsies: relevance for perinatal management. Pediatr Dev Pathol. 2010; 13, 465–470.CrossRefGoogle ScholarPubMed
11. Lehtonen, T, Markkula, T, Soidinsalo, P, Otonkoski, S, Laine, J. Causes of stillbirth in Turku, Finland, 2001–2011. Pediatr Dev Pathol. 2017; 20, 5–15.Google Scholar
12. StataCorp. Stata Statistical Software: Release 14. 2015. StataCorp LP: College Station, TX.Google Scholar
13. Bazin, D, Daudon, M, Combes, C, Rey, C. Characterization and some physicochemical aspects of pathological microcalcifications. Chem Rev. 2012; 112, 5092–5120.CrossRefGoogle ScholarPubMed
14. Kraus, FT. Placenta: thrombosis of fetal stem vessels with fetal thrombotic vasculopathy and chronic villitis. Pediatr Pathol Lab Med. 1996; 16, 143–148.Google ScholarPubMed
15. Carroll, SG, Maxwell, DJ. The significance of echogenic areas in the fetal abdomen. Ultrasound Obstet Gynecol. 1996; 7, 293–298.CrossRefGoogle ScholarPubMed
16. Shackelford, GD, Kirks, DR. Neonatal hepatic calcification secondary to transplacental infection. Radiology. 1977; 122, 753–757.CrossRefGoogle ScholarPubMed
17. Brugman, SM, Bjelland, JJ, Thomasson, JE, Anderson, SF, Giles, HR. Sonographic findings with radiologic correlation in meconium peritonitis. J Clin Ultrasound. 1979; 7, 305–306.CrossRefGoogle ScholarPubMed
18. Taylor, WG, Walkinshaw, SA, Thomson, MA. Antenatal assessment of neurological impairment. Arch Dis Child. 1993; 68, 604–605.CrossRefGoogle ScholarPubMed
19. Hawass, ND, el Badawi, MG, Fatani, JA, et al. Foetal hepatic calcification. Pediatr Radiol. 1990; 20, 528–535.CrossRefGoogle ScholarPubMed
20. Sahlin, E, Sirotkina, M, Marnerides, A, Iwarsson, E, Papadogiannakis, N. Fetal calcifications are associated with chromosomal abnormalities. PLoS One. 2015; 10, e0123343.CrossRefGoogle ScholarPubMed
21. Kidron, D, Sharony, R. Fetal liver calcifications: an autopsy study. Virchows Arch. 2012; 460, 399–406.CrossRefGoogle ScholarPubMed
22. Lince, DM, Pretorius, DH, Manco-Johnson, ML, Manchester, D, Clewell, WH. The clinical significance of increased echogenicity in the fetal abdomen. AJR Am J Roentgenol. 1985; 145, 683–686.CrossRefGoogle ScholarPubMed
23. Kraudel, K, Williams, CH. Ultrasound case report of hepatic teratoma in newborn. J Clin Ultrasound. 1984; 12, 98–101.CrossRefGoogle ScholarPubMed
24. Wax, JR, Blackstone, J, Pinette, MG, Cartin, A. Hepatic vascular calcification: an early second trimester sonographic feature of idiopathic infantile arterial calcinosis. Am J Obstet Gynecol. 2001; 185, 1267–1268.CrossRefGoogle ScholarPubMed
25. Butler, B, Anjum, U, Koehn, D. Prenatal diagnosis and outcome of fetal liver calcifications. Ultrasound Obstet Gynecol. 2011; 38(Suppl. 1), 168–281.Google Scholar
26. Bronshtein, M, Blazer, S. Prenatal diagnosis of liver calcifications. Obstet Gynecol. 1995; 86, 739–743.CrossRefGoogle ScholarPubMed
27. Pata, O, Gündüz, NM, Unlü, C. Isolated fetal liver calcifications. J Turk Ger Gynecol Assoc. 2012; 13, 67–69.Google ScholarPubMed