4 Modernizing clinical research: An administrative approach to unlocking the potential of decentralized clinical trials

Abstract

Objectives/Goals: Decentralized clinical trials (DCTs) shift participation outside traditional sites. This poster explores innovative administrative strategies for incorporating decentralized elements, improving flexibility, access, and efficiency in clinical research. Methods/Study Population: Modern administrative approaches are crucial for unlocking DCT potential by streamlining logistics, enhancing participant experience, and ensuring regulatory compliance. Key innovations include expedited IRB Review: using innovative template language; innovative consent strategies – eConsent and remote/virtual and contactless enrollment; telehealth communications – Twilio (voice calls and text messages)/Zoom (virtual video visits); automated participant compensation and rideshare services – Greenphire ClinCard®; flexible data collection – automated recruitment/intake forms and research surveys – REDCap; mobile research unit/self-collection lab kits via mail. Implementing decentralization into your study unlocks the potential to rapidly recruit more diverse populations. Results/Anticipated Results: The integration of decentralized elements into clinical trials holds significant potential for reducing participant burden, thereby improving recruitment, retention, and overall trial efficiency. However, the success of decentralized clinical trials relies heavily on the implementation of modern administrative approaches that streamline operations and maintain regulatory compliance. Together, these administrative advancements not only enhance the operational flexibility of decentralized trials but also support the inclusion of diverse populations by reducing geographical and logistical barriers. Discussion/Significance of Impact: As decentralized clinical trials continue to evolve, the adoption and further innovation of modern administrative solutions will be essential in improving the overall efficiency and inclusivity of clinical research.