In early 1982, 15 hospitals in Los Angeles County reported one or more serologically confirmed rubella cases among their employees. Secondary cases occurred at eight hospitals; overall, 56 cases were identified among employees, of which 28 were serologically confirmed. Testing of 2,061 employees revealed 1,770 (86%) with detectable antibody. A survey of 83 hospitals offering obstetrical services indicated only 42% (33 of 78) had an established rubella screening policy. Based on the results of this survey, the Los Angeles County Department of Health Services published recommendations for hospital rubella screening and immunization policies.

The bacteriologic content of expressed breast milk was studied in 30 mothers at the time of expression and after 24 and 48 hours of refrigeration. There were no significant differences in colony counts between the three time intervals. All samples contained Staphylococcus epidermidis. In addition, eight other species were found, including four which were gram-negative. All samples contained <106 colonies/ml, and there were no significant differences in mean colony counts between samples expressed at home and at the hospital. We conclude that it is bacteriologically safe to refrigerate expressed breast milk for up to 48 hours.

A retrospective review of microbiology records revealed 19 documented episodes of M. morganii bacteremia in 18 patients at a Veterans Administration hospital during a 5.5 year period. Thirteen of 19 bacteremias were related to nosocomial infections; 11 of the 13 nosocomial bacteremias occurred in surgical patients. Nine of the 13 patients with nosocomial bacteremia had received recent therapy with a beta-lactam antibiotic. The most common source of bacteremia was a postoperative wound infection (seven episodes). Only one episode was related to a urinary tract infection.

Retrospective analysis showed that clusters of cases of M. morganii bacteremia had occurred almost yearly. This finding prompted a six-month period of prospective monitoring of all cultures for M. morganii to identify human reservoirs in our institution. Sixty percent of all cultures growing M. morganii came from urine cultures, 18% came from wound cultures, and the remaining 22% came from a variety of body fluids or tube drainage. Thirty-one percent of patients harboring M. morganii were on the Surgical Service.

M. morganii bacteremia most commonly occurs in postoperative patients who receive beta-lactam antibiotics. From the data in this study, M. morganii is an infrequent cause of bacteremia, and its presence in blood cultures may be an indicator of an environment conducive for an outbreak of nosocomial infection.

Substitution of erythromycin ointment for silver nitrate in the prophylaxis of gonococcal ophthalmia neonatorum (GON) was accompanied by eight infections in 749 (1.1%) well-born and 21 infections in 285 (7.4%) intensive care infants during an eight-month period. This was significantly higher than previous rates of ophthalmitis during the use of silver nitrate, 0.3% (5/1877) and 2.1% (19/904) for well and intensive care infants, (P<0.01). Multiple bacteria were isolated, polymicrobial infection occurred frequently and the pattern of bacterial isolates did not favor cross-contamination between infants. Observation suggested the frequent unintentional introduction of ungloved fingers into neonatal eyes during attempts to insert erythromycin ointment. Replacement of ophthalmic ointment with a liquid tetracycline preparation resulted in a decrease in non-gonococcal ophthalmitis to rates similar to the baseline period 8/997 (0.8%) for both nurseries. The increased number of infections appear related to the ointment vehicle, difficulty in its application and the mechanical introduction of bacteria. It is inferred that appropriate application of liquid medication also reduced the risk of inadequate prophylaxis.

Coagulase-negative staphylococci (CONS) have only recently gained notoriety as pathogens. Several reports have established their pathogenicity in bacterial endocarditis, prosthetic heart valve endocarditis, intraventricular shunts for treatment of hydrocephalus and intravenous catheters. One difficult decision for physicians is determining whether a particular CONS isolate is pathogenic or contaminant. The differentiation of pathogenic and contaminant CONS has recently been noted, but further studies are needed to aid in this differentiation. Data on antimicrobial susceptibilities of positive blood culture isolates were recently compiled at this institution. This report compares antimicrobial susceptibilities of pathogenic and contaminant CONS and Staphylococcus aureus blood culture isolates from 1961-1981 at this institution.

Nosocomial (hospital-associated) infection continues to represent a major problem for hospitals. Gram-negative aerobic bacilli continue to be identified most frequently as etiologic agents, but a number of new pathogens now are recognized to play a role. The persons responsible for infection control efforts and in charge of the clinical microbiology laboratory (frequently the same person) must cooperate closely to attack this problem. The role of the laboratory in attempts to minimize occurrence of nosocomial infection involves six aspects: 1) accurate identification of responsible organisms, 2) timely reporting of laboratory data, 3) provision of additional studies, when necessary, to establish similarity or difference of organisms, 4) provision, on occasion, of microbiologic studies of the hospital environment, 5) training of infection control personnel, and 6) participation in activities of the hospital infection control committee.

The exigency for a comprehensive infectious waste management program in hospitals is influenced by federal guidelines and concern about the public image of our hospitals as a source of environmental pollution. The need to discard infectious waste in an aesthetically acceptable manner that will prevent hazards from injury and/or infection has received some recognition, but many states have not promulgated regulations on infectious waste management. Realizing the critical environmental health problems posed by improper disposal of infectious and other hazardous waste, Congress charged the Environmental Protection Agency (EPA) with the responsibility of formulating “cradle-to-grave” regulations over hazardous waste by requiring implementation of Subtitle C of the Resource Conservation and Recovery Act of 1976. Waste with infectious characteristics that may “pose a substantial present or potential hazard to human health or the environment when improperly … managed” are considered by this Act as hazardous waste. While by definition infectious waste is considered a subset of hazardous waste, the EPA has not yet issued regulations to fulfill the Congressional mandate to establish a management system for infectious waste. It has, however, prepared a technical manual which is intended to assist hospitals and states so they may establish appropriate programs and/or regulations on infectious waste management. This commentary will review some of the principles, practices, problems, products and services associated with infectious waste management.