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Secular Trends of Candidemia in a Large Tertiary-Care Hospital From 1988 to 2000: Emergence of Candida parapsilosis

Published online by Cambridge University Press:  21 June 2016

Lucía García San Miguel ,
Javier Cobo ,
Enrique Otheo ,
Aurora Sánchez-Sousa ,
Victor Abraira  and
Santiago Moreno
Lucía García San Miguel*
Affiliation:
Infectious Diseases Department, Ramón y Cajal HospitalMadrid, Spain
Javier Cobo
Affiliation:
Infectious Diseases Department, Ramón y Cajal HospitalMadrid, Spain
Enrique Otheo
Affiliation:
Pediatric Intensive Care Unit, Ramón y Cajal Hospital, Madrid, Spain
Aurora Sánchez-Sousa
Affiliation:
Microbiology Department, Ramón y Cajal HospitalMadrid, Spain
Victor Abraira
Affiliation:
Biostatistics Unit, Ramón y Cajal Hospital, Madrid, Spain
Santiago Moreno
Affiliation:
Infectious Diseases Department, Ramón y Cajal HospitalMadrid, Spain
*
Hospital Ramón y Cajal, Servicio de Enfermedades Infecciosas, Cta de Colmenar Km 9, 100, Madrid 28034, Spain[email protected]
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Abstract

Objective:

To analyze the secular trends of candidemia in a large tertiary-care hospital to determine the overall incidence, as well as the incidence by ward and by species, and to detect the occurrence of outbreaks.

Design:

Retrospective descriptive analysis. Secular trends were calculated using the Mantel-Haenszel test.

Setting:

A large tertiary-care referral center in Spain with a pediatric intensive care unit (ICU) to which more than 500 children with congenital cardiac disease are admitted annually.

Patients:

All patients with candidemia occurring from 1988 to 2000 were included. Cases were identified from laboratory records of blood cultures.

Results:

There were 331 episodes of candidemia. The overall incidence of nosocomial candidemia was 0.6 episode per 1,000 admissions and remained stable throughout the study period (P = .925). The species most frequently isolated was Candida albicans, but the incidence of C. parapsilosis candidemia increased (P = .035). In the pediatric ICU, the incidence of C. parapsilosis was 5.6 episodes per 1,000 admissions and it was the predominant species. Outbreaks occurred occasionally in the pediatric ICU, suggesting nosocomial transmission.

Conclusions:

During this 13-year period, the incidence of candidemia remained stable in this hospital, but C. parapsilosis increased in frequency. Occasional outbreaks of candidemia suggested nosocomial transmission of Candida species (Infect Control Hosp Epidemiol 2005;26:548-552).

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 26 , Issue 6 , June 2005 , pp. 548 - 552
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2005

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