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Feasibility of Azithromycin Prophylaxis During a Pertussis Outbreak Among Healthcare Workers in a University Hospital in Paris

Published online by Cambridge University Press:  21 June 2016

Camila Giugliani ,
Gwenaëlle Vidal-Trécan ,
Souleymane Traore ,
Hervé Blanchard ,
Gabriela Spiridon ,
Florence Rollot ,
Odile Launay ,
Myriam Gorodestski ,
Jean-Luc Marande  and
Christophe Vinsonneau
...Show all authors
Camila Giugliani
Affiliation:
Service de Santé Publique, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France Groupe Hospitalier Cochin–St. Vincent de Paul, AP-HP, and the Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Gwenaëlle Vidal-Trécan
Affiliation:
Service de Santé Publique, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France Groupe Hospitalier Cochin–St. Vincent de Paul, AP-HP, and the Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Souleymane Traore
Affiliation:
Service de Médecine Interne, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Hervé Blanchard
Affiliation:
Service d'Hygiène Hospitalière, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Gabriela Spiridon
Affiliation:
Service de Médecine Interne, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Florence Rollot
Affiliation:
Service de Médecine Interne, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France Groupe Hospitalier Cochin–St. Vincent de Paul, AP-HP, and the Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Odile Launay
Affiliation:
Service de Médecine Interne, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France Groupe Hospitalier Cochin–St. Vincent de Paul, AP-HP, and the Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Myriam Gorodestski
Affiliation:
Service de Médecine du Travail, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Jean-Luc Marande
Affiliation:
Service de Médecine du Travail, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Christophe Vinsonneau
Affiliation:
Service d'Hygiène Hospitalière, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Loïc Guillevin
Affiliation:
Service de Médecine Interne, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France Groupe Hospitalier Cochin–St. Vincent de Paul, AP-HP, and the Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Dominique Salmon-Céron*
Affiliation:
Service de Médecine Interne, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France Groupe Hospitalier Cochin–St. Vincent de Paul, AP-HP, and the Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
*
Service de Médecine Interne Unité de Maladies Infectieuses, Groupe Hospitalier Cochin–St. Vincent de Paul, 27, rue du Faubourg Saint Jacques 75014 Paris, France ([email protected])
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Abstract

The objective of the present study was to evaluate the feasibility of azithromycin prophylaxis with respect to tolerability and compliance during a pertussis outbreak among healthcare workers in a university hospital ward. Compliance with the prophylaxis regimen was 89%; compliance was 75% from intent-to-treat perspective. The rate of adverse events was 33%. Female sex was associated with reporting of adverse events. Nonstudents and healthcare workers who reported adverse events were less compliant with the prophylaxis regimen.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 27 , Issue 6 , June 2006 , pp. 626 - 629
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2006

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