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Evaluation of the Effect of Treatment of Latent Tuberculosis Infection on QuantiFERON-TB Gold Assay Results

Published online by Cambridge University Press:  02 January 2015

Nira R. Pollock ,
Suely S. Kashino ,
Danielle R. Napolitano ,
Alex Sloutsky ,
Swati Joshi ,
Jasmine Guillet ,
Michael Wong ,
Edward Nardell  and
Antonio Campos-Neto
Nira R. Pollock*
Affiliation:
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston
Suely S. Kashino
Affiliation:
Department of Cytokine Biology, Forsyth Institute, Boston
Danielle R. Napolitano
Affiliation:
Department of Cytokine Biology, Forsyth Institute, Boston
Alex Sloutsky
Affiliation:
Massachusetts State Laboratory Institute, Boston
Swati Joshi
Affiliation:
Massachusetts State Laboratory Institute, Boston
Jasmine Guillet
Affiliation:
Massachusetts State Laboratory Institute, Boston
Michael Wong
Affiliation:
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston
Edward Nardell
Affiliation:
Division of Social Medicine and Health Inequalities, Brigham and Women's Hospital, Boston
Antonio Campos-Neto
Affiliation:
Department of Cytokine Biology, Forsyth Institute, Boston Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts
*
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Lowry Medical Building, 110 Francis Street, Suite GB, Boston, MA 02215 ([email protected])
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Abstract

To evaluate the utility of the QuantiFERON-TB Gold assay for monitoring latent tuberculosis treatment efficacy, the assay was performed serially for healthcare workers receiving isoniazid therapy. After 9 months of isoniazid therapy, all of these healthcare workers remained QuantiFERON-TB Gold positive, and cellular proliferation assays revealed persistently strong purified protein derivative responses. These results do not support the use of the QuantiFERON-TB Gold assay to monitor therapy.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 30 , Issue 4 , April 2009 , pp. 392 - 395
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2009

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